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Experimental sleep deprivation as a tool to test memory deficits in rodents
Paradigms of sleep deprivation (SD) and memory testing in rodents (laboratory rats and mice) are here reviewed. The vast majority of these studies have been aimed at understanding the contribution of sleep to cognition, and in particular to memory. Relatively little attention, instead, has been devo...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861693/ https://www.ncbi.nlm.nih.gov/pubmed/24379759 http://dx.doi.org/10.3389/fnsys.2013.00106 |
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author | Colavito, Valeria Fabene, Paolo F. Grassi-Zucconi, Gigliola Pifferi, Fabien Lamberty, Yves Bentivoglio, Marina Bertini, Giuseppe |
author_facet | Colavito, Valeria Fabene, Paolo F. Grassi-Zucconi, Gigliola Pifferi, Fabien Lamberty, Yves Bentivoglio, Marina Bertini, Giuseppe |
author_sort | Colavito, Valeria |
collection | PubMed |
description | Paradigms of sleep deprivation (SD) and memory testing in rodents (laboratory rats and mice) are here reviewed. The vast majority of these studies have been aimed at understanding the contribution of sleep to cognition, and in particular to memory. Relatively little attention, instead, has been devoted to SD as a challenge to induce a transient memory impairment, and therefore as a tool to test cognitive enhancers in drug discovery. Studies that have accurately described methodological aspects of the SD protocol are first reviewed, followed by procedures to investigate SD-induced impairment of learning and memory consolidation in order to propose SD protocols that could be employed as cognitive challenge. Thus, a platform of knowledge is provided for laboratory protocols that could be used to assess the efficacy of drugs designed to improve memory performance in rodents, including rodent models of neurodegenerative diseases that cause cognitive deficits, and Alzheimer's disease in particular. Issues in the interpretation of such preclinical data and their predictive value for clinical translation are also discussed. |
format | Online Article Text |
id | pubmed-3861693 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-38616932013-12-30 Experimental sleep deprivation as a tool to test memory deficits in rodents Colavito, Valeria Fabene, Paolo F. Grassi-Zucconi, Gigliola Pifferi, Fabien Lamberty, Yves Bentivoglio, Marina Bertini, Giuseppe Front Syst Neurosci Neuroscience Paradigms of sleep deprivation (SD) and memory testing in rodents (laboratory rats and mice) are here reviewed. The vast majority of these studies have been aimed at understanding the contribution of sleep to cognition, and in particular to memory. Relatively little attention, instead, has been devoted to SD as a challenge to induce a transient memory impairment, and therefore as a tool to test cognitive enhancers in drug discovery. Studies that have accurately described methodological aspects of the SD protocol are first reviewed, followed by procedures to investigate SD-induced impairment of learning and memory consolidation in order to propose SD protocols that could be employed as cognitive challenge. Thus, a platform of knowledge is provided for laboratory protocols that could be used to assess the efficacy of drugs designed to improve memory performance in rodents, including rodent models of neurodegenerative diseases that cause cognitive deficits, and Alzheimer's disease in particular. Issues in the interpretation of such preclinical data and their predictive value for clinical translation are also discussed. Frontiers Media S.A. 2013-12-13 /pmc/articles/PMC3861693/ /pubmed/24379759 http://dx.doi.org/10.3389/fnsys.2013.00106 Text en Copyright © 2013 Colavito, Fabene, Grassi-Zucconi, Pifferi, Lamberty, Bentivoglio and Bertini. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Colavito, Valeria Fabene, Paolo F. Grassi-Zucconi, Gigliola Pifferi, Fabien Lamberty, Yves Bentivoglio, Marina Bertini, Giuseppe Experimental sleep deprivation as a tool to test memory deficits in rodents |
title | Experimental sleep deprivation as a tool to test memory deficits in rodents |
title_full | Experimental sleep deprivation as a tool to test memory deficits in rodents |
title_fullStr | Experimental sleep deprivation as a tool to test memory deficits in rodents |
title_full_unstemmed | Experimental sleep deprivation as a tool to test memory deficits in rodents |
title_short | Experimental sleep deprivation as a tool to test memory deficits in rodents |
title_sort | experimental sleep deprivation as a tool to test memory deficits in rodents |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861693/ https://www.ncbi.nlm.nih.gov/pubmed/24379759 http://dx.doi.org/10.3389/fnsys.2013.00106 |
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