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Experimental sleep deprivation as a tool to test memory deficits in rodents

Paradigms of sleep deprivation (SD) and memory testing in rodents (laboratory rats and mice) are here reviewed. The vast majority of these studies have been aimed at understanding the contribution of sleep to cognition, and in particular to memory. Relatively little attention, instead, has been devo...

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Autores principales: Colavito, Valeria, Fabene, Paolo F., Grassi-Zucconi, Gigliola, Pifferi, Fabien, Lamberty, Yves, Bentivoglio, Marina, Bertini, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861693/
https://www.ncbi.nlm.nih.gov/pubmed/24379759
http://dx.doi.org/10.3389/fnsys.2013.00106
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author Colavito, Valeria
Fabene, Paolo F.
Grassi-Zucconi, Gigliola
Pifferi, Fabien
Lamberty, Yves
Bentivoglio, Marina
Bertini, Giuseppe
author_facet Colavito, Valeria
Fabene, Paolo F.
Grassi-Zucconi, Gigliola
Pifferi, Fabien
Lamberty, Yves
Bentivoglio, Marina
Bertini, Giuseppe
author_sort Colavito, Valeria
collection PubMed
description Paradigms of sleep deprivation (SD) and memory testing in rodents (laboratory rats and mice) are here reviewed. The vast majority of these studies have been aimed at understanding the contribution of sleep to cognition, and in particular to memory. Relatively little attention, instead, has been devoted to SD as a challenge to induce a transient memory impairment, and therefore as a tool to test cognitive enhancers in drug discovery. Studies that have accurately described methodological aspects of the SD protocol are first reviewed, followed by procedures to investigate SD-induced impairment of learning and memory consolidation in order to propose SD protocols that could be employed as cognitive challenge. Thus, a platform of knowledge is provided for laboratory protocols that could be used to assess the efficacy of drugs designed to improve memory performance in rodents, including rodent models of neurodegenerative diseases that cause cognitive deficits, and Alzheimer's disease in particular. Issues in the interpretation of such preclinical data and their predictive value for clinical translation are also discussed.
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spelling pubmed-38616932013-12-30 Experimental sleep deprivation as a tool to test memory deficits in rodents Colavito, Valeria Fabene, Paolo F. Grassi-Zucconi, Gigliola Pifferi, Fabien Lamberty, Yves Bentivoglio, Marina Bertini, Giuseppe Front Syst Neurosci Neuroscience Paradigms of sleep deprivation (SD) and memory testing in rodents (laboratory rats and mice) are here reviewed. The vast majority of these studies have been aimed at understanding the contribution of sleep to cognition, and in particular to memory. Relatively little attention, instead, has been devoted to SD as a challenge to induce a transient memory impairment, and therefore as a tool to test cognitive enhancers in drug discovery. Studies that have accurately described methodological aspects of the SD protocol are first reviewed, followed by procedures to investigate SD-induced impairment of learning and memory consolidation in order to propose SD protocols that could be employed as cognitive challenge. Thus, a platform of knowledge is provided for laboratory protocols that could be used to assess the efficacy of drugs designed to improve memory performance in rodents, including rodent models of neurodegenerative diseases that cause cognitive deficits, and Alzheimer's disease in particular. Issues in the interpretation of such preclinical data and their predictive value for clinical translation are also discussed. Frontiers Media S.A. 2013-12-13 /pmc/articles/PMC3861693/ /pubmed/24379759 http://dx.doi.org/10.3389/fnsys.2013.00106 Text en Copyright © 2013 Colavito, Fabene, Grassi-Zucconi, Pifferi, Lamberty, Bentivoglio and Bertini. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Colavito, Valeria
Fabene, Paolo F.
Grassi-Zucconi, Gigliola
Pifferi, Fabien
Lamberty, Yves
Bentivoglio, Marina
Bertini, Giuseppe
Experimental sleep deprivation as a tool to test memory deficits in rodents
title Experimental sleep deprivation as a tool to test memory deficits in rodents
title_full Experimental sleep deprivation as a tool to test memory deficits in rodents
title_fullStr Experimental sleep deprivation as a tool to test memory deficits in rodents
title_full_unstemmed Experimental sleep deprivation as a tool to test memory deficits in rodents
title_short Experimental sleep deprivation as a tool to test memory deficits in rodents
title_sort experimental sleep deprivation as a tool to test memory deficits in rodents
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861693/
https://www.ncbi.nlm.nih.gov/pubmed/24379759
http://dx.doi.org/10.3389/fnsys.2013.00106
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