Paneth cells as a site of origin for intestinal inflammation

Autophagy related 16-like 1 (ATG16L1) as a genetic risk factor has exposed the critical role of autophagy in Crohn’s disease (CD)(1). Homozygosity for the highly prevalent ATG16L1 risk allele, or murine hypomorphic (HM) activity causes Paneth cell dysfunction(2,3). As Atg16l1(HM) mice do not develop...

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Detalles Bibliográficos
Autores principales: Adolph, Timon E., Tomczak, Michal F., Niederreiter, Lukas, Ko, Hyun-Jeong, Böck, Janne, Martinez-Naves, Eduardo, Glickman, Jonathan N., Tschurtschenthaler, Markus, Hartwig, John, Hosomi, Shuhei, Flak, Magdalena B., Cusick, Jennifer L., Kohno, Kenji, Iwawaki, Takao, Billmann-Born, Susanne, Raine, Tim, Bharti, Richta, Lucius, Ralph, Kweon, Mi-Na, Marciniak, Stefan J., Choi, Augustine, Hagen, Susan J., Schreiber, Stefan, Rosenstiel, Philip, Kaser, Arthur, Blumberg, Richard S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3862182/
https://www.ncbi.nlm.nih.gov/pubmed/24089213
http://dx.doi.org/10.1038/nature12599

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