Non-replicating Toxoplasma gondii reverses tumor-associated immunosuppression

We examined the efficacy of using attenuated non-replicating Toxoplasma gondii uracil auxotrophs that can be safely delivered as anticancer immunotherapeutics. This strategy exerted remarkable therapeutic activity in murine models of melanoma and ovarian carcinoma, and holds broad potential for the...

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Detalles Bibliográficos
Autores principales: Fox, Barbara A, Sanders, Kiah L, Bzik, David J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3862683/
https://www.ncbi.nlm.nih.gov/pubmed/24353916
http://dx.doi.org/10.4161/onci.26296
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author Fox, Barbara A
Sanders, Kiah L
Bzik, David J
author_facet Fox, Barbara A
Sanders, Kiah L
Bzik, David J
author_sort Fox, Barbara A
collection PubMed
description We examined the efficacy of using attenuated non-replicating Toxoplasma gondii uracil auxotrophs that can be safely delivered as anticancer immunotherapeutics. This strategy exerted remarkable therapeutic activity in murine models of melanoma and ovarian carcinoma, and holds broad potential for the development of novel, highly effective anticancer vaccines.
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spelling pubmed-38626832013-12-18 Non-replicating Toxoplasma gondii reverses tumor-associated immunosuppression Fox, Barbara A Sanders, Kiah L Bzik, David J Oncoimmunology Author's View We examined the efficacy of using attenuated non-replicating Toxoplasma gondii uracil auxotrophs that can be safely delivered as anticancer immunotherapeutics. This strategy exerted remarkable therapeutic activity in murine models of melanoma and ovarian carcinoma, and holds broad potential for the development of novel, highly effective anticancer vaccines. Landes Bioscience 2013-11-01 2013-10-09 /pmc/articles/PMC3862683/ /pubmed/24353916 http://dx.doi.org/10.4161/onci.26296 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Fox, Barbara A
Sanders, Kiah L
Bzik, David J
Non-replicating Toxoplasma gondii reverses tumor-associated immunosuppression
title Non-replicating Toxoplasma gondii reverses tumor-associated immunosuppression
title_full Non-replicating Toxoplasma gondii reverses tumor-associated immunosuppression
title_fullStr Non-replicating Toxoplasma gondii reverses tumor-associated immunosuppression
title_full_unstemmed Non-replicating Toxoplasma gondii reverses tumor-associated immunosuppression
title_short Non-replicating Toxoplasma gondii reverses tumor-associated immunosuppression
title_sort non-replicating toxoplasma gondii reverses tumor-associated immunosuppression
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3862683/
https://www.ncbi.nlm.nih.gov/pubmed/24353916
http://dx.doi.org/10.4161/onci.26296
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