Intratumoral mast cells promote the growth of pancreatic cancer

We have recently discovered that mast cells promote pancreatic tumorigenesis by exacerbating the cellular and extracellular signaling in the desmoplastic microenvironment. Our findings demonstrate for the first time that targeting mast cells can block the progression of pancreatic neoplasms and prol...

Descripción completa

Detalles Bibliográficos
Autores principales: Ma, Ying, Ullrich, Stephen E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3862685/
https://www.ncbi.nlm.nih.gov/pubmed/24353907
http://dx.doi.org/10.4161/onci.25964
_version_ 1782295772977430528
author Ma, Ying
Ullrich, Stephen E
author_facet Ma, Ying
Ullrich, Stephen E
author_sort Ma, Ying
collection PubMed
description We have recently discovered that mast cells promote pancreatic tumorigenesis by exacerbating the cellular and extracellular signaling in the desmoplastic microenvironment. Our findings demonstrate for the first time that targeting mast cells can block the progression of pancreatic neoplasms and prolong the survival of tumor-bearing immunocompetent hosts.
format Online
Article
Text
id pubmed-3862685
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Landes Bioscience
record_format MEDLINE/PubMed
spelling pubmed-38626852013-12-18 Intratumoral mast cells promote the growth of pancreatic cancer Ma, Ying Ullrich, Stephen E Oncoimmunology Author's View We have recently discovered that mast cells promote pancreatic tumorigenesis by exacerbating the cellular and extracellular signaling in the desmoplastic microenvironment. Our findings demonstrate for the first time that targeting mast cells can block the progression of pancreatic neoplasms and prolong the survival of tumor-bearing immunocompetent hosts. Landes Bioscience 2013-10-01 2013-08-02 /pmc/articles/PMC3862685/ /pubmed/24353907 http://dx.doi.org/10.4161/onci.25964 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Ma, Ying
Ullrich, Stephen E
Intratumoral mast cells promote the growth of pancreatic cancer
title Intratumoral mast cells promote the growth of pancreatic cancer
title_full Intratumoral mast cells promote the growth of pancreatic cancer
title_fullStr Intratumoral mast cells promote the growth of pancreatic cancer
title_full_unstemmed Intratumoral mast cells promote the growth of pancreatic cancer
title_short Intratumoral mast cells promote the growth of pancreatic cancer
title_sort intratumoral mast cells promote the growth of pancreatic cancer
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3862685/
https://www.ncbi.nlm.nih.gov/pubmed/24353907
http://dx.doi.org/10.4161/onci.25964
work_keys_str_mv AT maying intratumoralmastcellspromotethegrowthofpancreaticcancer
AT ullrichstephene intratumoralmastcellspromotethegrowthofpancreaticcancer

Ejemplares similares