Blockade of PD-1 immunosuppression boosts CAR T-cell therapy

The presence of an immunosuppressive microenvironment can limit the full potential of adoptive T cell immunotherapy. However, specific blockade of the PD-1 immunosuppressive pathway can significantly enhance the function of gene-modified T cells expressing a chimeric antigen receptor (CAR) leading t...

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Detalles Bibliográficos
Autores principales: John, Liza B, Kershaw, Michael H, Darcy, Phillip K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3862687/
https://www.ncbi.nlm.nih.gov/pubmed/24353912
http://dx.doi.org/10.4161/onci.26286
Descripción
Sumario:The presence of an immunosuppressive microenvironment can limit the full potential of adoptive T cell immunotherapy. However, specific blockade of the PD-1 immunosuppressive pathway can significantly enhance the function of gene-modified T cells expressing a chimeric antigen receptor (CAR) leading to enhanced tumor eradication.

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