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Blockade of PD-1 immunosuppression boosts CAR T-cell therapy
The presence of an immunosuppressive microenvironment can limit the full potential of adoptive T cell immunotherapy. However, specific blockade of the PD-1 immunosuppressive pathway can significantly enhance the function of gene-modified T cells expressing a chimeric antigen receptor (CAR) leading t...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Landes Bioscience
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3862687/ https://www.ncbi.nlm.nih.gov/pubmed/24353912 http://dx.doi.org/10.4161/onci.26286 |
| _version_ | 1782295773445095424 |
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| author | John, Liza B Kershaw, Michael H Darcy, Phillip K |
| author_facet | John, Liza B Kershaw, Michael H Darcy, Phillip K |
| author_sort | John, Liza B |
| collection | PubMed |
| description | The presence of an immunosuppressive microenvironment can limit the full potential of adoptive T cell immunotherapy. However, specific blockade of the PD-1 immunosuppressive pathway can significantly enhance the function of gene-modified T cells expressing a chimeric antigen receptor (CAR) leading to enhanced tumor eradication. |
| format | Online Article Text |
| id | pubmed-3862687 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2013 |
| publisher | Landes Bioscience |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-38626872013-12-18 Blockade of PD-1 immunosuppression boosts CAR T-cell therapy John, Liza B Kershaw, Michael H Darcy, Phillip K Oncoimmunology Author's View The presence of an immunosuppressive microenvironment can limit the full potential of adoptive T cell immunotherapy. However, specific blockade of the PD-1 immunosuppressive pathway can significantly enhance the function of gene-modified T cells expressing a chimeric antigen receptor (CAR) leading to enhanced tumor eradication. Landes Bioscience 2013-10-01 2013-10-10 /pmc/articles/PMC3862687/ /pubmed/24353912 http://dx.doi.org/10.4161/onci.26286 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
| spellingShingle | Author's View John, Liza B Kershaw, Michael H Darcy, Phillip K Blockade of PD-1 immunosuppression boosts CAR T-cell therapy |
| title | Blockade of PD-1 immunosuppression boosts CAR T-cell therapy |
| title_full | Blockade of PD-1 immunosuppression boosts CAR T-cell therapy |
| title_fullStr | Blockade of PD-1 immunosuppression boosts CAR T-cell therapy |
| title_full_unstemmed | Blockade of PD-1 immunosuppression boosts CAR T-cell therapy |
| title_short | Blockade of PD-1 immunosuppression boosts CAR T-cell therapy |
| title_sort | blockade of pd-1 immunosuppression boosts car t-cell therapy |
| topic | Author's View |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3862687/ https://www.ncbi.nlm.nih.gov/pubmed/24353912 http://dx.doi.org/10.4161/onci.26286 |
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