Cargando…

Blockade of PD-1 immunosuppression boosts CAR T-cell therapy

The presence of an immunosuppressive microenvironment can limit the full potential of adoptive T cell immunotherapy. However, specific blockade of the PD-1 immunosuppressive pathway can significantly enhance the function of gene-modified T cells expressing a chimeric antigen receptor (CAR) leading t...

Descripción completa

Detalles Bibliográficos
Autores principales:	John, Liza B, Kershaw, Michael H, Darcy, Phillip K
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Landes Bioscience 2013
Materias:	Author's View
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3862687/ https://www.ncbi.nlm.nih.gov/pubmed/24353912 http://dx.doi.org/10.4161/onci.26286

Ejemplares similares

A(2A) blockade enhances anti-metastatic immune responses
por: Beavis, Paul A, et al.
Publicado: (2013)

Blockade of the PD-1 pathway enhances the efficacy of adoptive cell therapy against cancer
por: Peng, Weiyi, et al.
Publicado: (2013)

Sugars boost exhausted tumor-infiltrating lymphocytes by counteracting immunosuppressive activities of galectins
por: Gordon-Alonso, Monica, et al.
Publicado: (2014)

Targeting HSP90 sensitizes pancreas carcinoma to PD-1 blockade
por: Liu, Jiao, et al.
Publicado: (2022)

A novel combinatorial cancer immunotherapy: poly-IC and blockade of the PD-1/PD-L1 pathway
por: Nagato, Toshihiro, et al.
Publicado: (2014)

Distinct immunological mechanisms of CTLA-4 and PD-1 blockade revealed by analyzing TCR usage in blood lymphocytes
por: Robert, Lidia, et al.
Publicado: (2014)

Polyamine blockade promotes antitumor immunity
por: Hayes, Candace S, et al.
Publicado: (2014)

Survivin the battle against immunosuppression
por: Manuel, Edwin R., et al.
Publicado: (2012)

Pro-survival signaling via CD27 costimulation drives effective CAR T-cell therapy
por: Song, De-Gang, et al.
Publicado: (2012)

Evidence of synergy with combined BRAF-targeted therapy and immune checkpoint blockade for metastatic melanoma
por: Cooper, Zachary A, et al.
Publicado: (2014)

Roadblocks to success for RNA CARs in solid tumors
por: Singh, Nathan, et al.
Publicado: (2015)

Thwarting galectin-induced immunosuppression in breast cancer
por: Salatino, Mariana, et al.
Publicado: (2013)

The role of soluble CD40L in immunosuppression
por: Schlom, Jeffrey, et al.
Publicado: (2013)

Acute myeloid leukemia therapeutics: CARs in the driver’s seat
por: Mardiros, Armen, et al.
Publicado: (2013)

Pancreatic cancer: Hurdles in the engineering of CAR-based immunotherapies
por: Abate-Daga, Daniel, et al.
Publicado: (2014)

Translating the combination of TGFβ blockade and radiotherapy into clinical development in glioblastoma
por: Zhang, Mengxian, et al.
Publicado: (2012)

Hypoxia-driven immunosuppression contributes to the pre-metastatic niche
por: Sceneay, Jaclyn, et al.
Publicado: (2013)

Interleukin-27 tackles immunosuppression in chronic lymphocytic leukemia
por: Fernandez Botana, Iria, et al.
Publicado: (2023)

Arming NK cells with enhanced antitumor activity: CARs and beyond
por: Oberoi, Pranav, et al.
Publicado: (2013)

Anti-PD-1 antibodies for the treatment of B-cell lymphoma: Importance of PD-1(+) T-cell subsets
por: Chu, Fuliang, et al.
Publicado: (2014)

CDK1/2/5 blockade: killing two birds with one stone
por: Liu, Jiao, et al.
Publicado: (2021)

REG3β contributes to the immunosuppressive microenvironment of pancreatic cancer
por: Folch-Puy, Emma
Publicado: (2013)

Non-replicating Toxoplasma gondii reverses tumor-associated immunosuppression
por: Fox, Barbara A, et al.
Publicado: (2013)

Forging a link between oncogenic signaling and immunosuppression in melanoma
por: Khalili, Jahan S., et al.
Publicado: (2013)

CTLA-4 blockade synergizes with cryoablation to mediate tumor rejection
por: Waitz, Rebecca, et al.
Publicado: (2012)

Boosting anticancer vaccines: Too much of a good thing?
por: Ricupito, Alessia, et al.
Publicado: (2013)

Pancreatic cancer-associated stellate cells: A viable target for reducing immunosuppression in the tumor microenvironment
por: Mace, Thomas A, et al.
Publicado: (2013)

Overcoming immunosuppression as a new immunotherapeutic approach against pancreatic cancer
por: Bazhin, Alexandr V, et al.
Publicado: (2013)

Contribution of regulatory T cells to immunosuppression and disease progression in multiple myeloma patients
por: Raja, Karthick Raja Muthu, et al.
Publicado: (2013)

New strategies for melanoma immunotherapy: How to overcome immunosuppression in the tumor microenvironment
por: Umansky, Viktor
Publicado: (2012)

‘Hardcore’ OX40(+) immunosuppressive regulatory T cells in hepatic cirrhosis and cancer
por: Piconese, Silvia, et al.
Publicado: (2014)

Triple threat to cancer: rationale for combining oncolytic viruses, MEK inhibitors, and immune checkpoint blockade
por: Bommareddy, Praveen K., et al.
Publicado: (2019)

Re-orienting the immune system: Durable tumor regression and successful re-induction therapy using anti-PD1 antibodies
por: Lipson, Evan J.
Publicado: (2013)

Replenish the source within: Rescuing tumor-infiltrating lymphocytes by double checkpoint blockade
por: Duraiswamy, Jaikumar, et al.
Publicado: (2013)

Mimotope vaccine efficacy gets a "boost" from native tumor antigens
por: Buhrman, Jonathan D., et al.
Publicado: (2013)

Boosting leukemia-specific T cell responses in patients following stem cell transplantation
por: Burkhardt, Ute E, et al.
Publicado: (2013)

High immunosuppressive burden in advanced hepatocellular carcinoma patients: Can effector functions be restored?
por: Lugade, Amit A, et al.
Publicado: (2013)

Dendritic cells matured in the presence of TLR ligands overcome the immunosuppressive functions of regulatory T cells
por: Berk, Erik, et al.
Publicado: (2014)

The fatal alliance of cancer and T cells: How pancreatic tumor cells gather immunosuppressive T cells
por: Grage-Griebenow, Evelin, et al.
Publicado: (2014)

Oxygenation to improve cancer vaccines, adoptive cell transfer and blockade of immunological negative regulators
por: Hatfield, Stephen M, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_oavhlvici8uu39ss5uobvkqmuu