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In patients with neovascular age-related macular degeneration, physical activity may influence C-reactive protein levels
PURPOSE: Association of neovascular age-related macular degeneration (AMD) with C-reactive protein (CRP) was previously reported, indicating a relation to systemic low-grade inflammation. However, visual impairment limits physical activity, and physical activity modulates CRP levels. Here, we invest...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3862739/ https://www.ncbi.nlm.nih.gov/pubmed/24363550 http://dx.doi.org/10.2147/OPTH.S55080 |
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author | Subhi, Yousif Singh, Amardeep Falk, Mads Krüger Sørensen, Torben Lykke |
author_facet | Subhi, Yousif Singh, Amardeep Falk, Mads Krüger Sørensen, Torben Lykke |
author_sort | Subhi, Yousif |
collection | PubMed |
description | PURPOSE: Association of neovascular age-related macular degeneration (AMD) with C-reactive protein (CRP) was previously reported, indicating a relation to systemic low-grade inflammation. However, visual impairment limits physical activity, and physical activity modulates CRP levels. Here, we investigated the impact of physical activity on CRP levels in patients with neovascular AMD and control individuals. SUBJECTS AND METHODS: We recruited participants from our outpatient AMD program, and control individuals from non-AMD patients, visitors, and department staff. After initial screening of 191 individuals, we included 98 patients with neovascular AMD and 77 controls. All were screened using digital fundus photography and optical coherence tomography, and interviewed about medical history and physical activity. Venous blood samples were obtained for high-sensitivity CRP. RESULTS: Physically active individuals had lower CRP than physically inactive individuals (P=0.003), and physical activity was associated with lower CRP in patients (P=0.038) and controls (P=0.031). Patients and controls did not differ in percentage physically active (P=0.807) or in overall CRP levels (P=0.394). The independent contribution of physical activity on CRP was confirmed in a multiple regression analysis (P=0.009), in which the presence of neovascular AMD did not contribute significantly (P=0.913). CONCLUSION: Our findings suggest that elevated CRP levels in patients with neovascular AMD are at least partly explained by physical inactivity. Future studies of systemic inflammation among the visually impaired should include disease-related implications, such as the impact of physical activity. |
format | Online Article Text |
id | pubmed-3862739 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-38627392013-12-20 In patients with neovascular age-related macular degeneration, physical activity may influence C-reactive protein levels Subhi, Yousif Singh, Amardeep Falk, Mads Krüger Sørensen, Torben Lykke Clin Ophthalmol Original Research PURPOSE: Association of neovascular age-related macular degeneration (AMD) with C-reactive protein (CRP) was previously reported, indicating a relation to systemic low-grade inflammation. However, visual impairment limits physical activity, and physical activity modulates CRP levels. Here, we investigated the impact of physical activity on CRP levels in patients with neovascular AMD and control individuals. SUBJECTS AND METHODS: We recruited participants from our outpatient AMD program, and control individuals from non-AMD patients, visitors, and department staff. After initial screening of 191 individuals, we included 98 patients with neovascular AMD and 77 controls. All were screened using digital fundus photography and optical coherence tomography, and interviewed about medical history and physical activity. Venous blood samples were obtained for high-sensitivity CRP. RESULTS: Physically active individuals had lower CRP than physically inactive individuals (P=0.003), and physical activity was associated with lower CRP in patients (P=0.038) and controls (P=0.031). Patients and controls did not differ in percentage physically active (P=0.807) or in overall CRP levels (P=0.394). The independent contribution of physical activity on CRP was confirmed in a multiple regression analysis (P=0.009), in which the presence of neovascular AMD did not contribute significantly (P=0.913). CONCLUSION: Our findings suggest that elevated CRP levels in patients with neovascular AMD are at least partly explained by physical inactivity. Future studies of systemic inflammation among the visually impaired should include disease-related implications, such as the impact of physical activity. Dove Medical Press 2013-12-09 /pmc/articles/PMC3862739/ /pubmed/24363550 http://dx.doi.org/10.2147/OPTH.S55080 Text en © 2014 Subhi et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Subhi, Yousif Singh, Amardeep Falk, Mads Krüger Sørensen, Torben Lykke In patients with neovascular age-related macular degeneration, physical activity may influence C-reactive protein levels |
title | In patients with neovascular age-related macular degeneration, physical activity may influence C-reactive protein levels |
title_full | In patients with neovascular age-related macular degeneration, physical activity may influence C-reactive protein levels |
title_fullStr | In patients with neovascular age-related macular degeneration, physical activity may influence C-reactive protein levels |
title_full_unstemmed | In patients with neovascular age-related macular degeneration, physical activity may influence C-reactive protein levels |
title_short | In patients with neovascular age-related macular degeneration, physical activity may influence C-reactive protein levels |
title_sort | in patients with neovascular age-related macular degeneration, physical activity may influence c-reactive protein levels |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3862739/ https://www.ncbi.nlm.nih.gov/pubmed/24363550 http://dx.doi.org/10.2147/OPTH.S55080 |
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