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Nanotechnology-based drug delivery systems and herbal medicines: a review

Herbal medicines have been widely used around the world since ancient times. The advancement of phytochemical and phytopharmacological sciences has enabled elucidation of the composition and biological activities of several medicinal plant products. The effectiveness of many species of medicinal pla...

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Autores principales: Bonifácio, Bruna Vidal, da Silva, Patricia Bento, Ramos, Matheus Aparecido dos Santos, Negri, Kamila Maria Silveira, Bauab, Taís Maria, Chorilli, Marlus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3862741/
https://www.ncbi.nlm.nih.gov/pubmed/24363556
http://dx.doi.org/10.2147/IJN.S52634
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author Bonifácio, Bruna Vidal
da Silva, Patricia Bento
Ramos, Matheus Aparecido dos Santos
Negri, Kamila Maria Silveira
Bauab, Taís Maria
Chorilli, Marlus
author_facet Bonifácio, Bruna Vidal
da Silva, Patricia Bento
Ramos, Matheus Aparecido dos Santos
Negri, Kamila Maria Silveira
Bauab, Taís Maria
Chorilli, Marlus
author_sort Bonifácio, Bruna Vidal
collection PubMed
description Herbal medicines have been widely used around the world since ancient times. The advancement of phytochemical and phytopharmacological sciences has enabled elucidation of the composition and biological activities of several medicinal plant products. The effectiveness of many species of medicinal plants depends on the supply of active compounds. Most of the biologically active constituents of extracts, such as flavonoids, tannins, and terpenoids, are highly soluble in water, but have low absorption, because they are unable to cross the lipid membranes of the cells, have excessively high molecular size, or are poorly absorbed, resulting in loss of bioavailability and efficacy. Some extracts are not used clinically because of these obstacles. It has been widely proposed to combine herbal medicine with nanotechnology, because nanostructured systems might be able to potentiate the action of plant extracts, reducing the required dose and side effects, and improving activity. Nanosystems can deliver the active constituent at a sufficient concentration during the entire treatment period, directing it to the desired site of action. Conventional treatments do not meet these requirements. The purpose of this study is to review nanotechnology-based drug delivery systems and herbal medicines.
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spelling pubmed-38627412013-12-20 Nanotechnology-based drug delivery systems and herbal medicines: a review Bonifácio, Bruna Vidal da Silva, Patricia Bento Ramos, Matheus Aparecido dos Santos Negri, Kamila Maria Silveira Bauab, Taís Maria Chorilli, Marlus Int J Nanomedicine Review Herbal medicines have been widely used around the world since ancient times. The advancement of phytochemical and phytopharmacological sciences has enabled elucidation of the composition and biological activities of several medicinal plant products. The effectiveness of many species of medicinal plants depends on the supply of active compounds. Most of the biologically active constituents of extracts, such as flavonoids, tannins, and terpenoids, are highly soluble in water, but have low absorption, because they are unable to cross the lipid membranes of the cells, have excessively high molecular size, or are poorly absorbed, resulting in loss of bioavailability and efficacy. Some extracts are not used clinically because of these obstacles. It has been widely proposed to combine herbal medicine with nanotechnology, because nanostructured systems might be able to potentiate the action of plant extracts, reducing the required dose and side effects, and improving activity. Nanosystems can deliver the active constituent at a sufficient concentration during the entire treatment period, directing it to the desired site of action. Conventional treatments do not meet these requirements. The purpose of this study is to review nanotechnology-based drug delivery systems and herbal medicines. Dove Medical Press 2013-12-09 /pmc/articles/PMC3862741/ /pubmed/24363556 http://dx.doi.org/10.2147/IJN.S52634 Text en © 2014 Bonifácio et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Review
Bonifácio, Bruna Vidal
da Silva, Patricia Bento
Ramos, Matheus Aparecido dos Santos
Negri, Kamila Maria Silveira
Bauab, Taís Maria
Chorilli, Marlus
Nanotechnology-based drug delivery systems and herbal medicines: a review
title Nanotechnology-based drug delivery systems and herbal medicines: a review
title_full Nanotechnology-based drug delivery systems and herbal medicines: a review
title_fullStr Nanotechnology-based drug delivery systems and herbal medicines: a review
title_full_unstemmed Nanotechnology-based drug delivery systems and herbal medicines: a review
title_short Nanotechnology-based drug delivery systems and herbal medicines: a review
title_sort nanotechnology-based drug delivery systems and herbal medicines: a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3862741/
https://www.ncbi.nlm.nih.gov/pubmed/24363556
http://dx.doi.org/10.2147/IJN.S52634
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