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Effects of Nutritional Supplementation during Pregnancy on Early Adult Disease Risk: Follow Up of Offspring of Participants in a Randomised Controlled Trial Investigating Effects of Supplementation on Infant Birth Weight
BACKGROUND: Observational evidence suggests that improving fetal growth may improve adult health. Experimental evidence from nutritional supplementation trials undertaken amongst pregnant women in the less developed world does not show strong or consistent effects on adult disease risk and no trials...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3862758/ https://www.ncbi.nlm.nih.gov/pubmed/24349496 http://dx.doi.org/10.1371/journal.pone.0083371 |
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author | Macleod, John Tang, Lie Hobbs, F. D. Richard Wharton, Brian Holder, Roger Hussain, Shakir Nichols, Linda Stewart, Paul Clark, Penny Luzio, Steve Holly, Jeff Davey Smith, George |
author_facet | Macleod, John Tang, Lie Hobbs, F. D. Richard Wharton, Brian Holder, Roger Hussain, Shakir Nichols, Linda Stewart, Paul Clark, Penny Luzio, Steve Holly, Jeff Davey Smith, George |
author_sort | Macleod, John |
collection | PubMed |
description | BACKGROUND: Observational evidence suggests that improving fetal growth may improve adult health. Experimental evidence from nutritional supplementation trials undertaken amongst pregnant women in the less developed world does not show strong or consistent effects on adult disease risk and no trials from the more developed world have previously been reported. OBJECTIVE: To test the hypothesis that nutritional supplementation during pregnancy influences offspring disease risk in adulthood DESIGN: Clinical assessment of a range of established diseases risk markers in young adult offspring of 283 South Asian mothers who participated in two trials of nutritional supplementation during pregnancy (protein/energy/vitamins; energy/vitamins or vitamins only) at Sorrento Maternity Hospital in Birmingham UK either unselected or selected on the basis of nutritional status. RESULTS: 236 (83%) offspring were traced and 118 (50%) of these were assessed in clinic. Protein/energy/vitamins supplementation amongst undernourished mothers was associated with increased infant birthweight. Nutritional supplementation showed no strong association with any one of a comprehensive range of markers of adult disease risk and no consistent pattern of association with risk across markers in offspring of either unselected or undernourished mothers. CONCLUSIONS: We found no evidence that nutritional supplements given to pregnant women are an important influence on adult disease risk however our study lacked power to estimate small effects. Our findings do not provide support for a policy of nutritional supplementation for pregnant women as an effective means to improve adult health in more developed societies. |
format | Online Article Text |
id | pubmed-3862758 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-38627582013-12-17 Effects of Nutritional Supplementation during Pregnancy on Early Adult Disease Risk: Follow Up of Offspring of Participants in a Randomised Controlled Trial Investigating Effects of Supplementation on Infant Birth Weight Macleod, John Tang, Lie Hobbs, F. D. Richard Wharton, Brian Holder, Roger Hussain, Shakir Nichols, Linda Stewart, Paul Clark, Penny Luzio, Steve Holly, Jeff Davey Smith, George PLoS One Research Article BACKGROUND: Observational evidence suggests that improving fetal growth may improve adult health. Experimental evidence from nutritional supplementation trials undertaken amongst pregnant women in the less developed world does not show strong or consistent effects on adult disease risk and no trials from the more developed world have previously been reported. OBJECTIVE: To test the hypothesis that nutritional supplementation during pregnancy influences offspring disease risk in adulthood DESIGN: Clinical assessment of a range of established diseases risk markers in young adult offspring of 283 South Asian mothers who participated in two trials of nutritional supplementation during pregnancy (protein/energy/vitamins; energy/vitamins or vitamins only) at Sorrento Maternity Hospital in Birmingham UK either unselected or selected on the basis of nutritional status. RESULTS: 236 (83%) offspring were traced and 118 (50%) of these were assessed in clinic. Protein/energy/vitamins supplementation amongst undernourished mothers was associated with increased infant birthweight. Nutritional supplementation showed no strong association with any one of a comprehensive range of markers of adult disease risk and no consistent pattern of association with risk across markers in offspring of either unselected or undernourished mothers. CONCLUSIONS: We found no evidence that nutritional supplements given to pregnant women are an important influence on adult disease risk however our study lacked power to estimate small effects. Our findings do not provide support for a policy of nutritional supplementation for pregnant women as an effective means to improve adult health in more developed societies. Public Library of Science 2013-12-13 /pmc/articles/PMC3862758/ /pubmed/24349496 http://dx.doi.org/10.1371/journal.pone.0083371 Text en © 2013 MacLeod et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Macleod, John Tang, Lie Hobbs, F. D. Richard Wharton, Brian Holder, Roger Hussain, Shakir Nichols, Linda Stewart, Paul Clark, Penny Luzio, Steve Holly, Jeff Davey Smith, George Effects of Nutritional Supplementation during Pregnancy on Early Adult Disease Risk: Follow Up of Offspring of Participants in a Randomised Controlled Trial Investigating Effects of Supplementation on Infant Birth Weight |
title | Effects of Nutritional Supplementation during Pregnancy on Early Adult Disease Risk: Follow Up of Offspring of Participants in a Randomised Controlled Trial Investigating Effects of Supplementation on Infant Birth Weight |
title_full | Effects of Nutritional Supplementation during Pregnancy on Early Adult Disease Risk: Follow Up of Offspring of Participants in a Randomised Controlled Trial Investigating Effects of Supplementation on Infant Birth Weight |
title_fullStr | Effects of Nutritional Supplementation during Pregnancy on Early Adult Disease Risk: Follow Up of Offspring of Participants in a Randomised Controlled Trial Investigating Effects of Supplementation on Infant Birth Weight |
title_full_unstemmed | Effects of Nutritional Supplementation during Pregnancy on Early Adult Disease Risk: Follow Up of Offspring of Participants in a Randomised Controlled Trial Investigating Effects of Supplementation on Infant Birth Weight |
title_short | Effects of Nutritional Supplementation during Pregnancy on Early Adult Disease Risk: Follow Up of Offspring of Participants in a Randomised Controlled Trial Investigating Effects of Supplementation on Infant Birth Weight |
title_sort | effects of nutritional supplementation during pregnancy on early adult disease risk: follow up of offspring of participants in a randomised controlled trial investigating effects of supplementation on infant birth weight |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3862758/ https://www.ncbi.nlm.nih.gov/pubmed/24349496 http://dx.doi.org/10.1371/journal.pone.0083371 |
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