From Knock-Out Phenotype to Three-Dimensional Structure of a Promising Antibiotic Target from Streptococcus pneumoniae

Given the rise in drug-resistant Streptococcus pneumoniae, there is an urgent need to discover new antimicrobials targeting this pathogen and an equally urgent need to characterize new drug targets. A promising antibiotic target is dihydrodipicolinate synthase (DHDPS), which catalyzes the rate-limit...

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Detalles Bibliográficos
Autores principales: Dogovski, Con, Gorman, Michael A., Ketaren, Natalia E., Praszkier, Judy, Zammit, Leanne M., Mertens, Haydyn D., Bryant, Gary, Yang, Ji, Griffin, Michael D. W., Pearce, F. Grant, Gerrard, Juliet A., Jameson, Geoffrey B., Parker, Michael W., Robins-Browne, Roy M., Perugini, Matthew A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3862839/
https://www.ncbi.nlm.nih.gov/pubmed/24349508
http://dx.doi.org/10.1371/journal.pone.0083419

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