Epoxy Fatty Acids and Inhibition of the Soluble Epoxide Hydrolase Selectively Modulate GABA Mediated Neurotransmission to Delay Onset of Seizures

In the brain, seizures lead to release of large amounts of polyunsaturated fatty acids including arachidonic acid (ARA). ARA is a substrate for three major enzymatic routes of metabolism by cyclooxygenase, lipoxygenase and cytochrome P450 enzymes. These enzymes convert ARA to potent lipid mediators...

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Detalles Bibliográficos
Autores principales: Inceoglu, Bora, Zolkowska, Dorota, Yoo, Hyun Ju, Wagner, Karen M., Yang, Jun, Hackett, Edward, Hwang, Sung Hee, Lee, Kin Sing Stephen, Rogawski, Michael A., Morisseau, Christophe, Hammock, Bruce D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3862847/
https://www.ncbi.nlm.nih.gov/pubmed/24349022
http://dx.doi.org/10.1371/journal.pone.0080922

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