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Osteoprotegerin (OPG) as a biomarker for diabetic cardiovascular complications
Osteoprotegerin (OPG) is a glycoprotein involved in bone metabolisms and with a regulatory role in immune, skeletal and vascular systems. Recently, circulating OPG levels have emerged as independent biomarkers of cardiovascular disease (CVD) in patients with acute or chronic heart disease, as well a...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Springer International Publishing
2013
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3863400/ https://www.ncbi.nlm.nih.gov/pubmed/24349960 http://dx.doi.org/10.1186/2193-1801-2-658 |
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author | Bjerre, Mette |
author_facet | Bjerre, Mette |
author_sort | Bjerre, Mette |
collection | PubMed |
description | Osteoprotegerin (OPG) is a glycoprotein involved in bone metabolisms and with a regulatory role in immune, skeletal and vascular systems. Recently, circulating OPG levels have emerged as independent biomarkers of cardiovascular disease (CVD) in patients with acute or chronic heart disease, as well as in the healthy population. Furthermore, OPG has been implicated in various inflammations and linked to diabetes and poor glycaemic control. This review focuses on the relations between circulating OPG levels and cardiovascular complications, with special emphasis on diabetic patients. OPG levels were observed to increase concurrently with the severity of diabetic complications, that is, with the highest circulating OPG levels observed in diabetic patients dying from CVD. Although the clinical prognostic use of OPG may seem far away, OPG does look promising as a biomarker in order to help the cardiologist to a better risk-stratification of the patients. |
format | Online Article Text |
id | pubmed-3863400 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-38634002013-12-17 Osteoprotegerin (OPG) as a biomarker for diabetic cardiovascular complications Bjerre, Mette Springerplus Review Osteoprotegerin (OPG) is a glycoprotein involved in bone metabolisms and with a regulatory role in immune, skeletal and vascular systems. Recently, circulating OPG levels have emerged as independent biomarkers of cardiovascular disease (CVD) in patients with acute or chronic heart disease, as well as in the healthy population. Furthermore, OPG has been implicated in various inflammations and linked to diabetes and poor glycaemic control. This review focuses on the relations between circulating OPG levels and cardiovascular complications, with special emphasis on diabetic patients. OPG levels were observed to increase concurrently with the severity of diabetic complications, that is, with the highest circulating OPG levels observed in diabetic patients dying from CVD. Although the clinical prognostic use of OPG may seem far away, OPG does look promising as a biomarker in order to help the cardiologist to a better risk-stratification of the patients. Springer International Publishing 2013-12-06 /pmc/articles/PMC3863400/ /pubmed/24349960 http://dx.doi.org/10.1186/2193-1801-2-658 Text en © Bjerre; licensee Springer. 2013 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Bjerre, Mette Osteoprotegerin (OPG) as a biomarker for diabetic cardiovascular complications |
title | Osteoprotegerin (OPG) as a biomarker for diabetic cardiovascular complications |
title_full | Osteoprotegerin (OPG) as a biomarker for diabetic cardiovascular complications |
title_fullStr | Osteoprotegerin (OPG) as a biomarker for diabetic cardiovascular complications |
title_full_unstemmed | Osteoprotegerin (OPG) as a biomarker for diabetic cardiovascular complications |
title_short | Osteoprotegerin (OPG) as a biomarker for diabetic cardiovascular complications |
title_sort | osteoprotegerin (opg) as a biomarker for diabetic cardiovascular complications |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3863400/ https://www.ncbi.nlm.nih.gov/pubmed/24349960 http://dx.doi.org/10.1186/2193-1801-2-658 |
work_keys_str_mv | AT bjerremette osteoprotegerinopgasabiomarkerfordiabeticcardiovascularcomplications |