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In Vitro Evaluation of Antibacterial Potential of Dry FruitExtracts of Elettaria cardamomum Maton (Chhoti Elaichi)

Emergence of resistance among pathogenic bacteria against available antibiotics is posing a great challenge to the current world. Thus, there is a great need to discover novel antibiotics. Traditional plants have been proved to be novel source in the search of antimicrobial compounds. The current st...

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Autores principales: Kaushik, Purshotam, Goyal, Pankaj, Chauhan, Abhishek, Chauhan, Garima
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shaheed Beheshti University of Medical Sciences 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3863444/
https://www.ncbi.nlm.nih.gov/pubmed/24363739
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author Kaushik, Purshotam
Goyal, Pankaj
Chauhan, Abhishek
Chauhan, Garima
author_facet Kaushik, Purshotam
Goyal, Pankaj
Chauhan, Abhishek
Chauhan, Garima
author_sort Kaushik, Purshotam
collection PubMed
description Emergence of resistance among pathogenic bacteria against available antibiotics is posing a great challenge to the current world. Thus, there is a great need to discover novel antibiotics. Traditional plants have been proved to be novel source in the search of antimicrobial compounds. The current study pertained to the susceptibilities of some clinically significant bacterial species to various crude extracts of Elettaria cardamomum Maton (Chhoti elaichi) dry fruits by agar well diffusion assay. Minimum inhibitory concentrations (MIC) of extracts were further evaluated against these bacteria. The study indicated that antibacterial activity of this plant is dependent on the type of extract and the organism evaluated. Ethanol extract was found to have comparatively higher activity than other organic and aqueous extracts. Gram-positive bacteria showed competent but variable susceptibilities to all the tested extracts. MIC data showed hopeful results as some of the extracts exhibited significant inhibitions of bacteria even at concentrations as low as 512 μg/mL. Overall, E. cardamomum seems to have significant antibacterial activity and to be very useful in the discovery of novel antibiotic.
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spelling pubmed-38634442013-12-20 In Vitro Evaluation of Antibacterial Potential of Dry FruitExtracts of Elettaria cardamomum Maton (Chhoti Elaichi) Kaushik, Purshotam Goyal, Pankaj Chauhan, Abhishek Chauhan, Garima Iran J Pharm Res Original Article Emergence of resistance among pathogenic bacteria against available antibiotics is posing a great challenge to the current world. Thus, there is a great need to discover novel antibiotics. Traditional plants have been proved to be novel source in the search of antimicrobial compounds. The current study pertained to the susceptibilities of some clinically significant bacterial species to various crude extracts of Elettaria cardamomum Maton (Chhoti elaichi) dry fruits by agar well diffusion assay. Minimum inhibitory concentrations (MIC) of extracts were further evaluated against these bacteria. The study indicated that antibacterial activity of this plant is dependent on the type of extract and the organism evaluated. Ethanol extract was found to have comparatively higher activity than other organic and aqueous extracts. Gram-positive bacteria showed competent but variable susceptibilities to all the tested extracts. MIC data showed hopeful results as some of the extracts exhibited significant inhibitions of bacteria even at concentrations as low as 512 μg/mL. Overall, E. cardamomum seems to have significant antibacterial activity and to be very useful in the discovery of novel antibiotic. Shaheed Beheshti University of Medical Sciences 2010 /pmc/articles/PMC3863444/ /pubmed/24363739 Text en © 2010 by School of Pharmacy, Shaheed Beheshti University of Medical Sciences and Health Services This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kaushik, Purshotam
Goyal, Pankaj
Chauhan, Abhishek
Chauhan, Garima
In Vitro Evaluation of Antibacterial Potential of Dry FruitExtracts of Elettaria cardamomum Maton (Chhoti Elaichi)
title In Vitro Evaluation of Antibacterial Potential of Dry FruitExtracts of Elettaria cardamomum Maton (Chhoti Elaichi)
title_full In Vitro Evaluation of Antibacterial Potential of Dry FruitExtracts of Elettaria cardamomum Maton (Chhoti Elaichi)
title_fullStr In Vitro Evaluation of Antibacterial Potential of Dry FruitExtracts of Elettaria cardamomum Maton (Chhoti Elaichi)
title_full_unstemmed In Vitro Evaluation of Antibacterial Potential of Dry FruitExtracts of Elettaria cardamomum Maton (Chhoti Elaichi)
title_short In Vitro Evaluation of Antibacterial Potential of Dry FruitExtracts of Elettaria cardamomum Maton (Chhoti Elaichi)
title_sort in vitro evaluation of antibacterial potential of dry fruitextracts of elettaria cardamomum maton (chhoti elaichi)
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3863444/
https://www.ncbi.nlm.nih.gov/pubmed/24363739
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