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Preparation of a Sustained Release Drug Delivery System for Dexamethasone by a Thermosensitive, In Situ Forming Hydrogel for Use in Differentiation of Dental Pulp

In situ forming delivery systems composed of block copolymers are attracting substantial attention due to their ease of use, biocompatibility, and biodegradability. In this study, the thermoresponsive triblock copolymer PLGA-PEG-PLGA was studied as a dexamethasone delivery system. Dexamethasone, a s...

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Autores principales: Khodaverdi, Elham, Kheirandish, Fatemeh, Mirzazadeh Tekie, Farnaz Sadat, Khashyarmanesh, Bibi Zahra, Hadizadeh, Farzin, Moallemzadeh Haghighi, Hamideh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3863485/
https://www.ncbi.nlm.nih.gov/pubmed/24369509
http://dx.doi.org/10.1155/2013/983053
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author Khodaverdi, Elham
Kheirandish, Fatemeh
Mirzazadeh Tekie, Farnaz Sadat
Khashyarmanesh, Bibi Zahra
Hadizadeh, Farzin
Moallemzadeh Haghighi, Hamideh
author_facet Khodaverdi, Elham
Kheirandish, Fatemeh
Mirzazadeh Tekie, Farnaz Sadat
Khashyarmanesh, Bibi Zahra
Hadizadeh, Farzin
Moallemzadeh Haghighi, Hamideh
author_sort Khodaverdi, Elham
collection PubMed
description In situ forming delivery systems composed of block copolymers are attracting substantial attention due to their ease of use, biocompatibility, and biodegradability. In this study, the thermoresponsive triblock copolymer PLGA-PEG-PLGA was studied as a dexamethasone delivery system. Dexamethasone, a synthetic glucocorticoid, is used clinically to improve inflammation, pain, and the hyperemesis of chemotherapy, and it is applied experimentally as a differentiation factor in tissue engineering. PLGA-PEG-PLGA was synthesised under microwave irradiation for 5 min. The obtained copolymer was characterised to determine its structure and phase transition temperature. An in vitro release study was conducted for various copolymer structures and drug concentrations. The yield of the reaction and HNMR analysis confirmed the appropriateness of the microwave-assisted method for PLGA-PEG-PLGA synthesis. Phase transition temperature was affected by the drug molecule as well as by the copolymer concentration and structure. An in vitro release study demonstrated that release occurs mainly by diffusion and does not depend on the copolymer structure or dexamethasone concentration.
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spelling pubmed-38634852013-12-25 Preparation of a Sustained Release Drug Delivery System for Dexamethasone by a Thermosensitive, In Situ Forming Hydrogel for Use in Differentiation of Dental Pulp Khodaverdi, Elham Kheirandish, Fatemeh Mirzazadeh Tekie, Farnaz Sadat Khashyarmanesh, Bibi Zahra Hadizadeh, Farzin Moallemzadeh Haghighi, Hamideh ISRN Pharm Research Article In situ forming delivery systems composed of block copolymers are attracting substantial attention due to their ease of use, biocompatibility, and biodegradability. In this study, the thermoresponsive triblock copolymer PLGA-PEG-PLGA was studied as a dexamethasone delivery system. Dexamethasone, a synthetic glucocorticoid, is used clinically to improve inflammation, pain, and the hyperemesis of chemotherapy, and it is applied experimentally as a differentiation factor in tissue engineering. PLGA-PEG-PLGA was synthesised under microwave irradiation for 5 min. The obtained copolymer was characterised to determine its structure and phase transition temperature. An in vitro release study was conducted for various copolymer structures and drug concentrations. The yield of the reaction and HNMR analysis confirmed the appropriateness of the microwave-assisted method for PLGA-PEG-PLGA synthesis. Phase transition temperature was affected by the drug molecule as well as by the copolymer concentration and structure. An in vitro release study demonstrated that release occurs mainly by diffusion and does not depend on the copolymer structure or dexamethasone concentration. Hindawi Publishing Corporation 2013-11-27 /pmc/articles/PMC3863485/ /pubmed/24369509 http://dx.doi.org/10.1155/2013/983053 Text en Copyright © 2013 Elham Khodaverdi et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Khodaverdi, Elham
Kheirandish, Fatemeh
Mirzazadeh Tekie, Farnaz Sadat
Khashyarmanesh, Bibi Zahra
Hadizadeh, Farzin
Moallemzadeh Haghighi, Hamideh
Preparation of a Sustained Release Drug Delivery System for Dexamethasone by a Thermosensitive, In Situ Forming Hydrogel for Use in Differentiation of Dental Pulp
title Preparation of a Sustained Release Drug Delivery System for Dexamethasone by a Thermosensitive, In Situ Forming Hydrogel for Use in Differentiation of Dental Pulp
title_full Preparation of a Sustained Release Drug Delivery System for Dexamethasone by a Thermosensitive, In Situ Forming Hydrogel for Use in Differentiation of Dental Pulp
title_fullStr Preparation of a Sustained Release Drug Delivery System for Dexamethasone by a Thermosensitive, In Situ Forming Hydrogel for Use in Differentiation of Dental Pulp
title_full_unstemmed Preparation of a Sustained Release Drug Delivery System for Dexamethasone by a Thermosensitive, In Situ Forming Hydrogel for Use in Differentiation of Dental Pulp
title_short Preparation of a Sustained Release Drug Delivery System for Dexamethasone by a Thermosensitive, In Situ Forming Hydrogel for Use in Differentiation of Dental Pulp
title_sort preparation of a sustained release drug delivery system for dexamethasone by a thermosensitive, in situ forming hydrogel for use in differentiation of dental pulp
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3863485/
https://www.ncbi.nlm.nih.gov/pubmed/24369509
http://dx.doi.org/10.1155/2013/983053
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