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Preparation of a Sustained Release Drug Delivery System for Dexamethasone by a Thermosensitive, In Situ Forming Hydrogel for Use in Differentiation of Dental Pulp
In situ forming delivery systems composed of block copolymers are attracting substantial attention due to their ease of use, biocompatibility, and biodegradability. In this study, the thermoresponsive triblock copolymer PLGA-PEG-PLGA was studied as a dexamethasone delivery system. Dexamethasone, a s...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3863485/ https://www.ncbi.nlm.nih.gov/pubmed/24369509 http://dx.doi.org/10.1155/2013/983053 |
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author | Khodaverdi, Elham Kheirandish, Fatemeh Mirzazadeh Tekie, Farnaz Sadat Khashyarmanesh, Bibi Zahra Hadizadeh, Farzin Moallemzadeh Haghighi, Hamideh |
author_facet | Khodaverdi, Elham Kheirandish, Fatemeh Mirzazadeh Tekie, Farnaz Sadat Khashyarmanesh, Bibi Zahra Hadizadeh, Farzin Moallemzadeh Haghighi, Hamideh |
author_sort | Khodaverdi, Elham |
collection | PubMed |
description | In situ forming delivery systems composed of block copolymers are attracting substantial attention due to their ease of use, biocompatibility, and biodegradability. In this study, the thermoresponsive triblock copolymer PLGA-PEG-PLGA was studied as a dexamethasone delivery system. Dexamethasone, a synthetic glucocorticoid, is used clinically to improve inflammation, pain, and the hyperemesis of chemotherapy, and it is applied experimentally as a differentiation factor in tissue engineering. PLGA-PEG-PLGA was synthesised under microwave irradiation for 5 min. The obtained copolymer was characterised to determine its structure and phase transition temperature. An in vitro release study was conducted for various copolymer structures and drug concentrations. The yield of the reaction and HNMR analysis confirmed the appropriateness of the microwave-assisted method for PLGA-PEG-PLGA synthesis. Phase transition temperature was affected by the drug molecule as well as by the copolymer concentration and structure. An in vitro release study demonstrated that release occurs mainly by diffusion and does not depend on the copolymer structure or dexamethasone concentration. |
format | Online Article Text |
id | pubmed-3863485 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-38634852013-12-25 Preparation of a Sustained Release Drug Delivery System for Dexamethasone by a Thermosensitive, In Situ Forming Hydrogel for Use in Differentiation of Dental Pulp Khodaverdi, Elham Kheirandish, Fatemeh Mirzazadeh Tekie, Farnaz Sadat Khashyarmanesh, Bibi Zahra Hadizadeh, Farzin Moallemzadeh Haghighi, Hamideh ISRN Pharm Research Article In situ forming delivery systems composed of block copolymers are attracting substantial attention due to their ease of use, biocompatibility, and biodegradability. In this study, the thermoresponsive triblock copolymer PLGA-PEG-PLGA was studied as a dexamethasone delivery system. Dexamethasone, a synthetic glucocorticoid, is used clinically to improve inflammation, pain, and the hyperemesis of chemotherapy, and it is applied experimentally as a differentiation factor in tissue engineering. PLGA-PEG-PLGA was synthesised under microwave irradiation for 5 min. The obtained copolymer was characterised to determine its structure and phase transition temperature. An in vitro release study was conducted for various copolymer structures and drug concentrations. The yield of the reaction and HNMR analysis confirmed the appropriateness of the microwave-assisted method for PLGA-PEG-PLGA synthesis. Phase transition temperature was affected by the drug molecule as well as by the copolymer concentration and structure. An in vitro release study demonstrated that release occurs mainly by diffusion and does not depend on the copolymer structure or dexamethasone concentration. Hindawi Publishing Corporation 2013-11-27 /pmc/articles/PMC3863485/ /pubmed/24369509 http://dx.doi.org/10.1155/2013/983053 Text en Copyright © 2013 Elham Khodaverdi et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Khodaverdi, Elham Kheirandish, Fatemeh Mirzazadeh Tekie, Farnaz Sadat Khashyarmanesh, Bibi Zahra Hadizadeh, Farzin Moallemzadeh Haghighi, Hamideh Preparation of a Sustained Release Drug Delivery System for Dexamethasone by a Thermosensitive, In Situ Forming Hydrogel for Use in Differentiation of Dental Pulp |
title | Preparation of a Sustained Release Drug Delivery System for Dexamethasone by a Thermosensitive, In Situ Forming Hydrogel for
Use in Differentiation of Dental Pulp |
title_full | Preparation of a Sustained Release Drug Delivery System for Dexamethasone by a Thermosensitive, In Situ Forming Hydrogel for
Use in Differentiation of Dental Pulp |
title_fullStr | Preparation of a Sustained Release Drug Delivery System for Dexamethasone by a Thermosensitive, In Situ Forming Hydrogel for
Use in Differentiation of Dental Pulp |
title_full_unstemmed | Preparation of a Sustained Release Drug Delivery System for Dexamethasone by a Thermosensitive, In Situ Forming Hydrogel for
Use in Differentiation of Dental Pulp |
title_short | Preparation of a Sustained Release Drug Delivery System for Dexamethasone by a Thermosensitive, In Situ Forming Hydrogel for
Use in Differentiation of Dental Pulp |
title_sort | preparation of a sustained release drug delivery system for dexamethasone by a thermosensitive, in situ forming hydrogel for
use in differentiation of dental pulp |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3863485/ https://www.ncbi.nlm.nih.gov/pubmed/24369509 http://dx.doi.org/10.1155/2013/983053 |
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