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The Expression of Netrin-1 in the Thymus and Its Effects on Thymocyte Adhesion and Migration

Netrin-1, a known axon guidance molecule, being a secreted laminin-related molecule, has been suggested to be involved in multiple physiological and pathological conditions, such as organogenesis, angiogenesis, tumorigenesis, and inflammation-mediated tissue injury. However, its function in thymocyt...

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Autores principales: Guo, Xiao-Kai, Liu, Yuan-Feng, Zhou, Yu, Sun, Xiu-Yuan, Qian, Xiao-Ping, Zhang, Yu, Zhang, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3863506/
https://www.ncbi.nlm.nih.gov/pubmed/24369474
http://dx.doi.org/10.1155/2013/462152
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author Guo, Xiao-Kai
Liu, Yuan-Feng
Zhou, Yu
Sun, Xiu-Yuan
Qian, Xiao-Ping
Zhang, Yu
Zhang, Jun
author_facet Guo, Xiao-Kai
Liu, Yuan-Feng
Zhou, Yu
Sun, Xiu-Yuan
Qian, Xiao-Ping
Zhang, Yu
Zhang, Jun
author_sort Guo, Xiao-Kai
collection PubMed
description Netrin-1, a known axon guidance molecule, being a secreted laminin-related molecule, has been suggested to be involved in multiple physiological and pathological conditions, such as organogenesis, angiogenesis, tumorigenesis, and inflammation-mediated tissue injury. However, its function in thymocyte development is still unknown. Here, we demonstrate that Netrin-1 is expressed in mouse thymus tissue and is primarily expressed in thymic stromal cells, and the expression of Netrin-1 in thymocytes can be induced by anti-CD3 antibody or IL-7 treatment. Importantly, Netrin-1 mediates the adhesion of thymocytes, and this effect is comparable to or greater than that of fibronectin. Furthermore, Netrin-1 specifically promotes the chemotaxis of CXCL12. These suggest that Netrin-1 may play an important role in thymocyte development.
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spelling pubmed-38635062013-12-25 The Expression of Netrin-1 in the Thymus and Its Effects on Thymocyte Adhesion and Migration Guo, Xiao-Kai Liu, Yuan-Feng Zhou, Yu Sun, Xiu-Yuan Qian, Xiao-Ping Zhang, Yu Zhang, Jun Clin Dev Immunol Research Article Netrin-1, a known axon guidance molecule, being a secreted laminin-related molecule, has been suggested to be involved in multiple physiological and pathological conditions, such as organogenesis, angiogenesis, tumorigenesis, and inflammation-mediated tissue injury. However, its function in thymocyte development is still unknown. Here, we demonstrate that Netrin-1 is expressed in mouse thymus tissue and is primarily expressed in thymic stromal cells, and the expression of Netrin-1 in thymocytes can be induced by anti-CD3 antibody or IL-7 treatment. Importantly, Netrin-1 mediates the adhesion of thymocytes, and this effect is comparable to or greater than that of fibronectin. Furthermore, Netrin-1 specifically promotes the chemotaxis of CXCL12. These suggest that Netrin-1 may play an important role in thymocyte development. Hindawi Publishing Corporation 2013 2013-11-28 /pmc/articles/PMC3863506/ /pubmed/24369474 http://dx.doi.org/10.1155/2013/462152 Text en Copyright © 2013 Xiao-Kai Guo et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Guo, Xiao-Kai
Liu, Yuan-Feng
Zhou, Yu
Sun, Xiu-Yuan
Qian, Xiao-Ping
Zhang, Yu
Zhang, Jun
The Expression of Netrin-1 in the Thymus and Its Effects on Thymocyte Adhesion and Migration
title The Expression of Netrin-1 in the Thymus and Its Effects on Thymocyte Adhesion and Migration
title_full The Expression of Netrin-1 in the Thymus and Its Effects on Thymocyte Adhesion and Migration
title_fullStr The Expression of Netrin-1 in the Thymus and Its Effects on Thymocyte Adhesion and Migration
title_full_unstemmed The Expression of Netrin-1 in the Thymus and Its Effects on Thymocyte Adhesion and Migration
title_short The Expression of Netrin-1 in the Thymus and Its Effects on Thymocyte Adhesion and Migration
title_sort expression of netrin-1 in the thymus and its effects on thymocyte adhesion and migration
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3863506/
https://www.ncbi.nlm.nih.gov/pubmed/24369474
http://dx.doi.org/10.1155/2013/462152
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