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The Expression of Netrin-1 in the Thymus and Its Effects on Thymocyte Adhesion and Migration
Netrin-1, a known axon guidance molecule, being a secreted laminin-related molecule, has been suggested to be involved in multiple physiological and pathological conditions, such as organogenesis, angiogenesis, tumorigenesis, and inflammation-mediated tissue injury. However, its function in thymocyt...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3863506/ https://www.ncbi.nlm.nih.gov/pubmed/24369474 http://dx.doi.org/10.1155/2013/462152 |
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author | Guo, Xiao-Kai Liu, Yuan-Feng Zhou, Yu Sun, Xiu-Yuan Qian, Xiao-Ping Zhang, Yu Zhang, Jun |
author_facet | Guo, Xiao-Kai Liu, Yuan-Feng Zhou, Yu Sun, Xiu-Yuan Qian, Xiao-Ping Zhang, Yu Zhang, Jun |
author_sort | Guo, Xiao-Kai |
collection | PubMed |
description | Netrin-1, a known axon guidance molecule, being a secreted laminin-related molecule, has been suggested to be involved in multiple physiological and pathological conditions, such as organogenesis, angiogenesis, tumorigenesis, and inflammation-mediated tissue injury. However, its function in thymocyte development is still unknown. Here, we demonstrate that Netrin-1 is expressed in mouse thymus tissue and is primarily expressed in thymic stromal cells, and the expression of Netrin-1 in thymocytes can be induced by anti-CD3 antibody or IL-7 treatment. Importantly, Netrin-1 mediates the adhesion of thymocytes, and this effect is comparable to or greater than that of fibronectin. Furthermore, Netrin-1 specifically promotes the chemotaxis of CXCL12. These suggest that Netrin-1 may play an important role in thymocyte development. |
format | Online Article Text |
id | pubmed-3863506 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-38635062013-12-25 The Expression of Netrin-1 in the Thymus and Its Effects on Thymocyte Adhesion and Migration Guo, Xiao-Kai Liu, Yuan-Feng Zhou, Yu Sun, Xiu-Yuan Qian, Xiao-Ping Zhang, Yu Zhang, Jun Clin Dev Immunol Research Article Netrin-1, a known axon guidance molecule, being a secreted laminin-related molecule, has been suggested to be involved in multiple physiological and pathological conditions, such as organogenesis, angiogenesis, tumorigenesis, and inflammation-mediated tissue injury. However, its function in thymocyte development is still unknown. Here, we demonstrate that Netrin-1 is expressed in mouse thymus tissue and is primarily expressed in thymic stromal cells, and the expression of Netrin-1 in thymocytes can be induced by anti-CD3 antibody or IL-7 treatment. Importantly, Netrin-1 mediates the adhesion of thymocytes, and this effect is comparable to or greater than that of fibronectin. Furthermore, Netrin-1 specifically promotes the chemotaxis of CXCL12. These suggest that Netrin-1 may play an important role in thymocyte development. Hindawi Publishing Corporation 2013 2013-11-28 /pmc/articles/PMC3863506/ /pubmed/24369474 http://dx.doi.org/10.1155/2013/462152 Text en Copyright © 2013 Xiao-Kai Guo et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Guo, Xiao-Kai Liu, Yuan-Feng Zhou, Yu Sun, Xiu-Yuan Qian, Xiao-Ping Zhang, Yu Zhang, Jun The Expression of Netrin-1 in the Thymus and Its Effects on Thymocyte Adhesion and Migration |
title | The Expression of Netrin-1 in the Thymus and Its Effects on Thymocyte Adhesion and Migration |
title_full | The Expression of Netrin-1 in the Thymus and Its Effects on Thymocyte Adhesion and Migration |
title_fullStr | The Expression of Netrin-1 in the Thymus and Its Effects on Thymocyte Adhesion and Migration |
title_full_unstemmed | The Expression of Netrin-1 in the Thymus and Its Effects on Thymocyte Adhesion and Migration |
title_short | The Expression of Netrin-1 in the Thymus and Its Effects on Thymocyte Adhesion and Migration |
title_sort | expression of netrin-1 in the thymus and its effects on thymocyte adhesion and migration |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3863506/ https://www.ncbi.nlm.nih.gov/pubmed/24369474 http://dx.doi.org/10.1155/2013/462152 |
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