Interferon-Regulatory Factors Determine Macrophage Phenotype Polarization

The mononuclear phagocyte system regulates tissue homeostasis as well as all phases of tissue injury and repair. To do so changing tissue environments alter the phenotype of tissue macrophages to assure their support for sustaining and amplifying their respective surrounding environment. Interferon-...

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Detalles Bibliográficos
Autores principales: Günthner, Roman, Anders, Hans-Joachim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3863528/
https://www.ncbi.nlm.nih.gov/pubmed/24379524
http://dx.doi.org/10.1155/2013/731023
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author Günthner, Roman
Anders, Hans-Joachim
author_facet Günthner, Roman
Anders, Hans-Joachim
author_sort Günthner, Roman
collection PubMed
description The mononuclear phagocyte system regulates tissue homeostasis as well as all phases of tissue injury and repair. To do so changing tissue environments alter the phenotype of tissue macrophages to assure their support for sustaining and amplifying their respective surrounding environment. Interferon-regulatory factors are intracellular signaling elements that determine the maturation and gene transcription of leukocytes. Here we discuss how several among the 9 interferon-regulatory factors contribute to macrophage polarization.
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spelling pubmed-38635282013-12-30 Interferon-Regulatory Factors Determine Macrophage Phenotype Polarization Günthner, Roman Anders, Hans-Joachim Mediators Inflamm Review Article The mononuclear phagocyte system regulates tissue homeostasis as well as all phases of tissue injury and repair. To do so changing tissue environments alter the phenotype of tissue macrophages to assure their support for sustaining and amplifying their respective surrounding environment. Interferon-regulatory factors are intracellular signaling elements that determine the maturation and gene transcription of leukocytes. Here we discuss how several among the 9 interferon-regulatory factors contribute to macrophage polarization. Hindawi Publishing Corporation 2013 2013-11-28 /pmc/articles/PMC3863528/ /pubmed/24379524 http://dx.doi.org/10.1155/2013/731023 Text en Copyright © 2013 R. Günthner and H.-J. Anders. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Günthner, Roman
Anders, Hans-Joachim
Interferon-Regulatory Factors Determine Macrophage Phenotype Polarization
title Interferon-Regulatory Factors Determine Macrophage Phenotype Polarization
title_full Interferon-Regulatory Factors Determine Macrophage Phenotype Polarization
title_fullStr Interferon-Regulatory Factors Determine Macrophage Phenotype Polarization
title_full_unstemmed Interferon-Regulatory Factors Determine Macrophage Phenotype Polarization
title_short Interferon-Regulatory Factors Determine Macrophage Phenotype Polarization
title_sort interferon-regulatory factors determine macrophage phenotype polarization
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3863528/
https://www.ncbi.nlm.nih.gov/pubmed/24379524
http://dx.doi.org/10.1155/2013/731023
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