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Acute and Subchronic Toxic Effects of the Fruits of Physalis peruviana L.

The fruit of Physalis peruviana L. (PPL) has been traditionally used as antispasmodic, diuretic, antiseptic, sedative, and analgesic all over the world. We aimed to perform qualitative content analysis of the fruits of PPL and to clarify the in vitro genotoxicity and in vivo acute and subchronic tox...

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Autores principales: Perk, Basak Ozlem, Ilgin, Sinem, Atli, Ozlem, Duymus, Hale Gamze, Sirmagul, Basar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3863561/
https://www.ncbi.nlm.nih.gov/pubmed/24369482
http://dx.doi.org/10.1155/2013/707285
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author Perk, Basak Ozlem
Ilgin, Sinem
Atli, Ozlem
Duymus, Hale Gamze
Sirmagul, Basar
author_facet Perk, Basak Ozlem
Ilgin, Sinem
Atli, Ozlem
Duymus, Hale Gamze
Sirmagul, Basar
author_sort Perk, Basak Ozlem
collection PubMed
description The fruit of Physalis peruviana L. (PPL) has been traditionally used as antispasmodic, diuretic, antiseptic, sedative, and analgesic all over the world. We aimed to perform qualitative content analysis of the fruits of PPL and to clarify the in vitro genotoxicity and in vivo acute and subchronic toxicity of the fruit. Lyophilized fruit juice does not induce genetic damage. In the acute toxicity studies, LD50 value of the fruit was found to be more than 5000 mg kg(−1) for both sexes. According to the subchronic toxicity studies, hepatic, renal, and hematological toxic effects were not induced in both sexes. Plasma troponin I (only in the group treated with 5000 mg kg(−1) of lyophilized fruit juice) and troponin T levels were significantly increased in male groups treated with lyophilized fruit juice compared to the control group. Furthermore, potassium level was significantly increased in the male group treated with 5000 mg kg(−1) of lyophilized fruit juice. These findings were considered to indicate the myocardial damage particularly in the male group treated with 5000 mg kg(−1) of lyophilized fruit juice. In conclusion, lyophilized fruit juice of PPL is shown to induce cardiac toxicity only at high doses and in male gender.
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spelling pubmed-38635612013-12-25 Acute and Subchronic Toxic Effects of the Fruits of Physalis peruviana L. Perk, Basak Ozlem Ilgin, Sinem Atli, Ozlem Duymus, Hale Gamze Sirmagul, Basar Evid Based Complement Alternat Med Research Article The fruit of Physalis peruviana L. (PPL) has been traditionally used as antispasmodic, diuretic, antiseptic, sedative, and analgesic all over the world. We aimed to perform qualitative content analysis of the fruits of PPL and to clarify the in vitro genotoxicity and in vivo acute and subchronic toxicity of the fruit. Lyophilized fruit juice does not induce genetic damage. In the acute toxicity studies, LD50 value of the fruit was found to be more than 5000 mg kg(−1) for both sexes. According to the subchronic toxicity studies, hepatic, renal, and hematological toxic effects were not induced in both sexes. Plasma troponin I (only in the group treated with 5000 mg kg(−1) of lyophilized fruit juice) and troponin T levels were significantly increased in male groups treated with lyophilized fruit juice compared to the control group. Furthermore, potassium level was significantly increased in the male group treated with 5000 mg kg(−1) of lyophilized fruit juice. These findings were considered to indicate the myocardial damage particularly in the male group treated with 5000 mg kg(−1) of lyophilized fruit juice. In conclusion, lyophilized fruit juice of PPL is shown to induce cardiac toxicity only at high doses and in male gender. Hindawi Publishing Corporation 2013 2013-11-28 /pmc/articles/PMC3863561/ /pubmed/24369482 http://dx.doi.org/10.1155/2013/707285 Text en Copyright © 2013 Basak Ozlem Perk et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Perk, Basak Ozlem
Ilgin, Sinem
Atli, Ozlem
Duymus, Hale Gamze
Sirmagul, Basar
Acute and Subchronic Toxic Effects of the Fruits of Physalis peruviana L.
title Acute and Subchronic Toxic Effects of the Fruits of Physalis peruviana L.
title_full Acute and Subchronic Toxic Effects of the Fruits of Physalis peruviana L.
title_fullStr Acute and Subchronic Toxic Effects of the Fruits of Physalis peruviana L.
title_full_unstemmed Acute and Subchronic Toxic Effects of the Fruits of Physalis peruviana L.
title_short Acute and Subchronic Toxic Effects of the Fruits of Physalis peruviana L.
title_sort acute and subchronic toxic effects of the fruits of physalis peruviana l.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3863561/
https://www.ncbi.nlm.nih.gov/pubmed/24369482
http://dx.doi.org/10.1155/2013/707285
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