Long-term Effect of Sodium Oxybate (Xyrem®) in Spasmodic Dysphonia with Vocal Tremor

BACKGROUND: Symptoms of spasmodic dysphonia (SD) are usually managed successfully with botulinum toxin injections. Vocal tremor (VT), which accompanies SD, has a poor response to this treatment. CASE REPORT: We report a case of a female with SD and VT who became symptom-free for 10 months after the...

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Detalles Bibliográficos
Autores principales: Simonyan, Kristina, Frucht, Steven J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Columbia University Libraries/Information Services 2013
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3863985/
https://www.ncbi.nlm.nih.gov/pubmed/24386608
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author Simonyan, Kristina
Frucht, Steven J.
author_facet Simonyan, Kristina
Frucht, Steven J.
author_sort Simonyan, Kristina
collection PubMed
description BACKGROUND: Symptoms of spasmodic dysphonia (SD) are usually managed successfully with botulinum toxin injections. Vocal tremor (VT), which accompanies SD, has a poor response to this treatment. CASE REPORT: We report a case of a female with SD and VT who became symptom-free for 10 months after the intake of a single dose of sodium oxybate (Xyrem®). The long-term treatment effect correlated with attenuated brain activity in the key regions of dystonic brain network. DISCUSSION: Our case demonstrates that the novel treatment of sodium oxybate may hold promise for SD patients, especially those who have associated VT.
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spelling pubmed-38639852014-01-02 Long-term Effect of Sodium Oxybate (Xyrem®) in Spasmodic Dysphonia with Vocal Tremor Simonyan, Kristina Frucht, Steven J. Tremor Other Hyperkinet Mov (N Y) Case Reports BACKGROUND: Symptoms of spasmodic dysphonia (SD) are usually managed successfully with botulinum toxin injections. Vocal tremor (VT), which accompanies SD, has a poor response to this treatment. CASE REPORT: We report a case of a female with SD and VT who became symptom-free for 10 months after the intake of a single dose of sodium oxybate (Xyrem®). The long-term treatment effect correlated with attenuated brain activity in the key regions of dystonic brain network. DISCUSSION: Our case demonstrates that the novel treatment of sodium oxybate may hold promise for SD patients, especially those who have associated VT. Columbia University Libraries/Information Services 2013-12-09 /pmc/articles/PMC3863985/ /pubmed/24386608 Text en http://creativecommons.org/licenses/by-nc-nd/3.0/us/ This is an open-access article distributed under the terms of the Creative Commons Attribution–Noncommerical–No Derivatives License, which permits the user to copy, distribute, and transmit the work provided that the original author and source are credited; that no commercial use is made of the work; and that the work is not altered or transformed.
spellingShingle Case Reports
Simonyan, Kristina
Frucht, Steven J.
Long-term Effect of Sodium Oxybate (Xyrem®) in Spasmodic Dysphonia with Vocal Tremor
title Long-term Effect of Sodium Oxybate (Xyrem®) in Spasmodic Dysphonia with Vocal Tremor
title_full Long-term Effect of Sodium Oxybate (Xyrem®) in Spasmodic Dysphonia with Vocal Tremor
title_fullStr Long-term Effect of Sodium Oxybate (Xyrem®) in Spasmodic Dysphonia with Vocal Tremor
title_full_unstemmed Long-term Effect of Sodium Oxybate (Xyrem®) in Spasmodic Dysphonia with Vocal Tremor
title_short Long-term Effect of Sodium Oxybate (Xyrem®) in Spasmodic Dysphonia with Vocal Tremor
title_sort long-term effect of sodium oxybate (xyrem®) in spasmodic dysphonia with vocal tremor
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3863985/
https://www.ncbi.nlm.nih.gov/pubmed/24386608
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AT fruchtstevenj longtermeffectofsodiumoxybatexyreminspasmodicdysphoniawithvocaltremor

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