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The Effect of Perioperative Immunonutrition on the Phagocytic Activity of Blood Platelets in Advanced Gastric Cancer Patients

Background and Aims. Perioperative immunonutrition can influence the phagocytic activity of platelets in advanced gastric cancer. Methods. 51 patients with stage IV gastric cancer divided into four groups depending on the clinical status and 40 normal donors were analyzed. Patients of groups I and I...

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Autores principales: Kamocki, Zbigniew, Matowicka-Karna, Joanna, Gryko, Mariusz, Zareba, Konrad, Kedra, Boguslaw, Kemona, Halina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3864072/
https://www.ncbi.nlm.nih.gov/pubmed/24363760
http://dx.doi.org/10.1155/2013/435672
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author Kamocki, Zbigniew
Matowicka-Karna, Joanna
Gryko, Mariusz
Zareba, Konrad
Kedra, Boguslaw
Kemona, Halina
author_facet Kamocki, Zbigniew
Matowicka-Karna, Joanna
Gryko, Mariusz
Zareba, Konrad
Kedra, Boguslaw
Kemona, Halina
author_sort Kamocki, Zbigniew
collection PubMed
description Background and Aims. Perioperative immunonutrition can influence the phagocytic activity of platelets in advanced gastric cancer. Methods. 51 patients with stage IV gastric cancer divided into four groups depending on the clinical status and 40 normal donors were analyzed. Patients of groups I and II underwent palliative gastrectomy. Patients of groups III and IV had exploratory laparotomy. Perioperative immunonutrition was administered as follows: group I—TPN, II—oral arginine, peripheral TPN, III—TPN preoperatively, and IV—without nutrition. The phagocytic activity of blood platelets was determined before and after nutritional therapy and was assessed by measuring the fraction of phagocytic thrombocytes (%phag) and the phagocytic index (Ixphag). Results. The percentage of phagocytizing platelets and the phagocytic index prior to and after the surgery amounted to the following: group I—1.136–1.237, P = NS, and 1.007–1.1, P = NS, respectively, II—1.111–1.25, P < 0.05, and 1.011–1.083, P < 0.05, III—1.112–1.186, P = NS, and 0.962–1.042, P = NS, and IV—1.085–0.96, P = NS, and 1.023–1.04, P = NS. Conclusions. The phagocytic activity of platelets in patients with advanced gastric cancer is significantly impaired. Perioperative immunonutrition with oral arginine-rich diet can partially improve the phagocytic activity of blood platelets. This trial is registred with Clinicaltrials.gov-NCT01704664.
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spelling pubmed-38640722013-12-22 The Effect of Perioperative Immunonutrition on the Phagocytic Activity of Blood Platelets in Advanced Gastric Cancer Patients Kamocki, Zbigniew Matowicka-Karna, Joanna Gryko, Mariusz Zareba, Konrad Kedra, Boguslaw Kemona, Halina Clin Dev Immunol Research Article Background and Aims. Perioperative immunonutrition can influence the phagocytic activity of platelets in advanced gastric cancer. Methods. 51 patients with stage IV gastric cancer divided into four groups depending on the clinical status and 40 normal donors were analyzed. Patients of groups I and II underwent palliative gastrectomy. Patients of groups III and IV had exploratory laparotomy. Perioperative immunonutrition was administered as follows: group I—TPN, II—oral arginine, peripheral TPN, III—TPN preoperatively, and IV—without nutrition. The phagocytic activity of blood platelets was determined before and after nutritional therapy and was assessed by measuring the fraction of phagocytic thrombocytes (%phag) and the phagocytic index (Ixphag). Results. The percentage of phagocytizing platelets and the phagocytic index prior to and after the surgery amounted to the following: group I—1.136–1.237, P = NS, and 1.007–1.1, P = NS, respectively, II—1.111–1.25, P < 0.05, and 1.011–1.083, P < 0.05, III—1.112–1.186, P = NS, and 0.962–1.042, P = NS, and IV—1.085–0.96, P = NS, and 1.023–1.04, P = NS. Conclusions. The phagocytic activity of platelets in patients with advanced gastric cancer is significantly impaired. Perioperative immunonutrition with oral arginine-rich diet can partially improve the phagocytic activity of blood platelets. This trial is registred with Clinicaltrials.gov-NCT01704664. Hindawi Publishing Corporation 2013 2013-12-01 /pmc/articles/PMC3864072/ /pubmed/24363760 http://dx.doi.org/10.1155/2013/435672 Text en Copyright © 2013 Zbigniew Kamocki et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Kamocki, Zbigniew
Matowicka-Karna, Joanna
Gryko, Mariusz
Zareba, Konrad
Kedra, Boguslaw
Kemona, Halina
The Effect of Perioperative Immunonutrition on the Phagocytic Activity of Blood Platelets in Advanced Gastric Cancer Patients
title The Effect of Perioperative Immunonutrition on the Phagocytic Activity of Blood Platelets in Advanced Gastric Cancer Patients
title_full The Effect of Perioperative Immunonutrition on the Phagocytic Activity of Blood Platelets in Advanced Gastric Cancer Patients
title_fullStr The Effect of Perioperative Immunonutrition on the Phagocytic Activity of Blood Platelets in Advanced Gastric Cancer Patients
title_full_unstemmed The Effect of Perioperative Immunonutrition on the Phagocytic Activity of Blood Platelets in Advanced Gastric Cancer Patients
title_short The Effect of Perioperative Immunonutrition on the Phagocytic Activity of Blood Platelets in Advanced Gastric Cancer Patients
title_sort effect of perioperative immunonutrition on the phagocytic activity of blood platelets in advanced gastric cancer patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3864072/
https://www.ncbi.nlm.nih.gov/pubmed/24363760
http://dx.doi.org/10.1155/2013/435672
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