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Sperm Proteomics: Road to Male Fertility and Contraception

Spermatozoa are highly specialized cells that can be easily obtained and purified. Mature spermatozoa are transcriptionally and translationally inactive and incapable of protein synthesis. In addition, spermatozoa contain relatively higher amounts of membrane proteins compared to other cells; theref...

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Autores principales: Rahman, Md Saidur, Lee, June-Sub, Kwon, Woo-Sung, Pang, Myung-Geol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3864079/
https://www.ncbi.nlm.nih.gov/pubmed/24363670
http://dx.doi.org/10.1155/2013/360986
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author Rahman, Md Saidur
Lee, June-Sub
Kwon, Woo-Sung
Pang, Myung-Geol
author_facet Rahman, Md Saidur
Lee, June-Sub
Kwon, Woo-Sung
Pang, Myung-Geol
author_sort Rahman, Md Saidur
collection PubMed
description Spermatozoa are highly specialized cells that can be easily obtained and purified. Mature spermatozoa are transcriptionally and translationally inactive and incapable of protein synthesis. In addition, spermatozoa contain relatively higher amounts of membrane proteins compared to other cells; therefore, they are very suitable for proteomic studies. Recently, the application of proteomic approaches such as the two-dimensional polyacrylamide gel electrophoresis, mass spectrometry, and differential in-gel electrophoresis has identified several sperm-specific proteins. These findings have provided a further understanding of protein functions involved in different sperm processes as well as of the differentiation of normal state from an abnormal one. In addition, studies on the sperm proteome have demonstrated the importance of spermatozoal posttranslational modifications and their ability to induce physiological changes responsible for fertilization. Large-scale proteomic studies to identify hundreds to thousands of sperm proteins will ultimately result in the development of novel biomarkers that may help to detect fertility, the state of complete contraception, and beyond. Eventually, these protein biomarkers will allow for a better diagnosis of sperm dysfunctions and aid in drug development. This paper reviews the recent scientific publications available from the PubMed database to address sperm proteomics and its potential application to characterize male fertility and contraception.
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spelling pubmed-38640792013-12-22 Sperm Proteomics: Road to Male Fertility and Contraception Rahman, Md Saidur Lee, June-Sub Kwon, Woo-Sung Pang, Myung-Geol Int J Endocrinol Review Article Spermatozoa are highly specialized cells that can be easily obtained and purified. Mature spermatozoa are transcriptionally and translationally inactive and incapable of protein synthesis. In addition, spermatozoa contain relatively higher amounts of membrane proteins compared to other cells; therefore, they are very suitable for proteomic studies. Recently, the application of proteomic approaches such as the two-dimensional polyacrylamide gel electrophoresis, mass spectrometry, and differential in-gel electrophoresis has identified several sperm-specific proteins. These findings have provided a further understanding of protein functions involved in different sperm processes as well as of the differentiation of normal state from an abnormal one. In addition, studies on the sperm proteome have demonstrated the importance of spermatozoal posttranslational modifications and their ability to induce physiological changes responsible for fertilization. Large-scale proteomic studies to identify hundreds to thousands of sperm proteins will ultimately result in the development of novel biomarkers that may help to detect fertility, the state of complete contraception, and beyond. Eventually, these protein biomarkers will allow for a better diagnosis of sperm dysfunctions and aid in drug development. This paper reviews the recent scientific publications available from the PubMed database to address sperm proteomics and its potential application to characterize male fertility and contraception. Hindawi Publishing Corporation 2013 2013-12-01 /pmc/articles/PMC3864079/ /pubmed/24363670 http://dx.doi.org/10.1155/2013/360986 Text en Copyright © 2013 Md Saidur Rahman et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Rahman, Md Saidur
Lee, June-Sub
Kwon, Woo-Sung
Pang, Myung-Geol
Sperm Proteomics: Road to Male Fertility and Contraception
title Sperm Proteomics: Road to Male Fertility and Contraception
title_full Sperm Proteomics: Road to Male Fertility and Contraception
title_fullStr Sperm Proteomics: Road to Male Fertility and Contraception
title_full_unstemmed Sperm Proteomics: Road to Male Fertility and Contraception
title_short Sperm Proteomics: Road to Male Fertility and Contraception
title_sort sperm proteomics: road to male fertility and contraception
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3864079/
https://www.ncbi.nlm.nih.gov/pubmed/24363670
http://dx.doi.org/10.1155/2013/360986
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