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Sperm Proteomics: Road to Male Fertility and Contraception
Spermatozoa are highly specialized cells that can be easily obtained and purified. Mature spermatozoa are transcriptionally and translationally inactive and incapable of protein synthesis. In addition, spermatozoa contain relatively higher amounts of membrane proteins compared to other cells; theref...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3864079/ https://www.ncbi.nlm.nih.gov/pubmed/24363670 http://dx.doi.org/10.1155/2013/360986 |
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author | Rahman, Md Saidur Lee, June-Sub Kwon, Woo-Sung Pang, Myung-Geol |
author_facet | Rahman, Md Saidur Lee, June-Sub Kwon, Woo-Sung Pang, Myung-Geol |
author_sort | Rahman, Md Saidur |
collection | PubMed |
description | Spermatozoa are highly specialized cells that can be easily obtained and purified. Mature spermatozoa are transcriptionally and translationally inactive and incapable of protein synthesis. In addition, spermatozoa contain relatively higher amounts of membrane proteins compared to other cells; therefore, they are very suitable for proteomic studies. Recently, the application of proteomic approaches such as the two-dimensional polyacrylamide gel electrophoresis, mass spectrometry, and differential in-gel electrophoresis has identified several sperm-specific proteins. These findings have provided a further understanding of protein functions involved in different sperm processes as well as of the differentiation of normal state from an abnormal one. In addition, studies on the sperm proteome have demonstrated the importance of spermatozoal posttranslational modifications and their ability to induce physiological changes responsible for fertilization. Large-scale proteomic studies to identify hundreds to thousands of sperm proteins will ultimately result in the development of novel biomarkers that may help to detect fertility, the state of complete contraception, and beyond. Eventually, these protein biomarkers will allow for a better diagnosis of sperm dysfunctions and aid in drug development. This paper reviews the recent scientific publications available from the PubMed database to address sperm proteomics and its potential application to characterize male fertility and contraception. |
format | Online Article Text |
id | pubmed-3864079 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-38640792013-12-22 Sperm Proteomics: Road to Male Fertility and Contraception Rahman, Md Saidur Lee, June-Sub Kwon, Woo-Sung Pang, Myung-Geol Int J Endocrinol Review Article Spermatozoa are highly specialized cells that can be easily obtained and purified. Mature spermatozoa are transcriptionally and translationally inactive and incapable of protein synthesis. In addition, spermatozoa contain relatively higher amounts of membrane proteins compared to other cells; therefore, they are very suitable for proteomic studies. Recently, the application of proteomic approaches such as the two-dimensional polyacrylamide gel electrophoresis, mass spectrometry, and differential in-gel electrophoresis has identified several sperm-specific proteins. These findings have provided a further understanding of protein functions involved in different sperm processes as well as of the differentiation of normal state from an abnormal one. In addition, studies on the sperm proteome have demonstrated the importance of spermatozoal posttranslational modifications and their ability to induce physiological changes responsible for fertilization. Large-scale proteomic studies to identify hundreds to thousands of sperm proteins will ultimately result in the development of novel biomarkers that may help to detect fertility, the state of complete contraception, and beyond. Eventually, these protein biomarkers will allow for a better diagnosis of sperm dysfunctions and aid in drug development. This paper reviews the recent scientific publications available from the PubMed database to address sperm proteomics and its potential application to characterize male fertility and contraception. Hindawi Publishing Corporation 2013 2013-12-01 /pmc/articles/PMC3864079/ /pubmed/24363670 http://dx.doi.org/10.1155/2013/360986 Text en Copyright © 2013 Md Saidur Rahman et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Rahman, Md Saidur Lee, June-Sub Kwon, Woo-Sung Pang, Myung-Geol Sperm Proteomics: Road to Male Fertility and Contraception |
title | Sperm Proteomics: Road to Male Fertility and Contraception |
title_full | Sperm Proteomics: Road to Male Fertility and Contraception |
title_fullStr | Sperm Proteomics: Road to Male Fertility and Contraception |
title_full_unstemmed | Sperm Proteomics: Road to Male Fertility and Contraception |
title_short | Sperm Proteomics: Road to Male Fertility and Contraception |
title_sort | sperm proteomics: road to male fertility and contraception |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3864079/ https://www.ncbi.nlm.nih.gov/pubmed/24363670 http://dx.doi.org/10.1155/2013/360986 |
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