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Expression of the Classical and Nonclassical HLA Molecules in Breast Cancer
Considering that downregulation of HLA expression could represent a potential mechanism for breast carcinogenesis and metastasis, the aim of the present study was to use immunohistochemical methods to analyze the expression of HLA-Ia, HLA-DR, HLA-DQ, HLA-E, and HLA-G in invasive ductal carcinoma (ID...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3864140/ https://www.ncbi.nlm.nih.gov/pubmed/24363939 http://dx.doi.org/10.1155/2013/250435 |
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author | da Silva, Gisela Bevilacqua Rolfsen Ferreira Silva, Tarsia Giabardo Alves Duarte, Roberta Aparecida Neto, Nicolino Lia Carrara, Hélio Humberto Angotti Donadi, Eduardo Antônio Gonçalves, Maria Alice Guimarães Soares, Edson Garcia Soares, Christiane Pienna |
author_facet | da Silva, Gisela Bevilacqua Rolfsen Ferreira Silva, Tarsia Giabardo Alves Duarte, Roberta Aparecida Neto, Nicolino Lia Carrara, Hélio Humberto Angotti Donadi, Eduardo Antônio Gonçalves, Maria Alice Guimarães Soares, Edson Garcia Soares, Christiane Pienna |
author_sort | da Silva, Gisela Bevilacqua Rolfsen Ferreira |
collection | PubMed |
description | Considering that downregulation of HLA expression could represent a potential mechanism for breast carcinogenesis and metastasis, the aim of the present study was to use immunohistochemical methods to analyze the expression of HLA-Ia, HLA-DR, HLA-DQ, HLA-E, and HLA-G in invasive ductal carcinoma (IDC) of the breast and to relate this HLA profile to anatomopathological parameters. Fifty-two IDC from breast biopsies were stratified according to histological differentiation (well, moderately, and poorly differentiated) and to the presence of metastases in axillary lymph nodes. The expression of HLA molecules was assessed by immunohistochemistry, using a computer-assisted system. Overall, 31 (59.6%) out of the 52 IDC breast biopsies exhibited high expression of HLA-G, but only 14 (26.9%) showed high expression of HLA-E. A large number (41, 78.8%) of the biopsies showed low expression of HLA-Ia, while 45 (86.5%) showed high expression of HLA-DQ and 36 (69.2%) underexpressed HLA-DR. Moreover, 24 (41.2%) of 52 biopsies had both low HLA-Ia expression and high HLA-G expression, while 11 (21.2%) had low HLA-Ia expression and high HLA-E expression. These results suggest that, by different mechanisms, the downregulation of HLA-Ia, HLA-E, and HLA-DR and the upregulation of HLA-G and HLA-DQ are associated with immune response evasion and breast cancer aggressiveness. |
format | Online Article Text |
id | pubmed-3864140 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-38641402013-12-22 Expression of the Classical and Nonclassical HLA Molecules in Breast Cancer da Silva, Gisela Bevilacqua Rolfsen Ferreira Silva, Tarsia Giabardo Alves Duarte, Roberta Aparecida Neto, Nicolino Lia Carrara, Hélio Humberto Angotti Donadi, Eduardo Antônio Gonçalves, Maria Alice Guimarães Soares, Edson Garcia Soares, Christiane Pienna Int J Breast Cancer Research Article Considering that downregulation of HLA expression could represent a potential mechanism for breast carcinogenesis and metastasis, the aim of the present study was to use immunohistochemical methods to analyze the expression of HLA-Ia, HLA-DR, HLA-DQ, HLA-E, and HLA-G in invasive ductal carcinoma (IDC) of the breast and to relate this HLA profile to anatomopathological parameters. Fifty-two IDC from breast biopsies were stratified according to histological differentiation (well, moderately, and poorly differentiated) and to the presence of metastases in axillary lymph nodes. The expression of HLA molecules was assessed by immunohistochemistry, using a computer-assisted system. Overall, 31 (59.6%) out of the 52 IDC breast biopsies exhibited high expression of HLA-G, but only 14 (26.9%) showed high expression of HLA-E. A large number (41, 78.8%) of the biopsies showed low expression of HLA-Ia, while 45 (86.5%) showed high expression of HLA-DQ and 36 (69.2%) underexpressed HLA-DR. Moreover, 24 (41.2%) of 52 biopsies had both low HLA-Ia expression and high HLA-G expression, while 11 (21.2%) had low HLA-Ia expression and high HLA-E expression. These results suggest that, by different mechanisms, the downregulation of HLA-Ia, HLA-E, and HLA-DR and the upregulation of HLA-G and HLA-DQ are associated with immune response evasion and breast cancer aggressiveness. Hindawi Publishing Corporation 2013 2013-12-02 /pmc/articles/PMC3864140/ /pubmed/24363939 http://dx.doi.org/10.1155/2013/250435 Text en Copyright © 2013 Gisela Bevilacqua Rolfsen Ferreira da Silva et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article da Silva, Gisela Bevilacqua Rolfsen Ferreira Silva, Tarsia Giabardo Alves Duarte, Roberta Aparecida Neto, Nicolino Lia Carrara, Hélio Humberto Angotti Donadi, Eduardo Antônio Gonçalves, Maria Alice Guimarães Soares, Edson Garcia Soares, Christiane Pienna Expression of the Classical and Nonclassical HLA Molecules in Breast Cancer |
title | Expression of the Classical and Nonclassical HLA Molecules in Breast Cancer |
title_full | Expression of the Classical and Nonclassical HLA Molecules in Breast Cancer |
title_fullStr | Expression of the Classical and Nonclassical HLA Molecules in Breast Cancer |
title_full_unstemmed | Expression of the Classical and Nonclassical HLA Molecules in Breast Cancer |
title_short | Expression of the Classical and Nonclassical HLA Molecules in Breast Cancer |
title_sort | expression of the classical and nonclassical hla molecules in breast cancer |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3864140/ https://www.ncbi.nlm.nih.gov/pubmed/24363939 http://dx.doi.org/10.1155/2013/250435 |
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