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Expression of the Classical and Nonclassical HLA Molecules in Breast Cancer

Considering that downregulation of HLA expression could represent a potential mechanism for breast carcinogenesis and metastasis, the aim of the present study was to use immunohistochemical methods to analyze the expression of HLA-Ia, HLA-DR, HLA-DQ, HLA-E, and HLA-G in invasive ductal carcinoma (ID...

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Autores principales: da Silva, Gisela Bevilacqua Rolfsen Ferreira, Silva, Tarsia Giabardo Alves, Duarte, Roberta Aparecida, Neto, Nicolino Lia, Carrara, Hélio Humberto Angotti, Donadi, Eduardo Antônio, Gonçalves, Maria Alice Guimarães, Soares, Edson Garcia, Soares, Christiane Pienna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3864140/
https://www.ncbi.nlm.nih.gov/pubmed/24363939
http://dx.doi.org/10.1155/2013/250435
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author da Silva, Gisela Bevilacqua Rolfsen Ferreira
Silva, Tarsia Giabardo Alves
Duarte, Roberta Aparecida
Neto, Nicolino Lia
Carrara, Hélio Humberto Angotti
Donadi, Eduardo Antônio
Gonçalves, Maria Alice Guimarães
Soares, Edson Garcia
Soares, Christiane Pienna
author_facet da Silva, Gisela Bevilacqua Rolfsen Ferreira
Silva, Tarsia Giabardo Alves
Duarte, Roberta Aparecida
Neto, Nicolino Lia
Carrara, Hélio Humberto Angotti
Donadi, Eduardo Antônio
Gonçalves, Maria Alice Guimarães
Soares, Edson Garcia
Soares, Christiane Pienna
author_sort da Silva, Gisela Bevilacqua Rolfsen Ferreira
collection PubMed
description Considering that downregulation of HLA expression could represent a potential mechanism for breast carcinogenesis and metastasis, the aim of the present study was to use immunohistochemical methods to analyze the expression of HLA-Ia, HLA-DR, HLA-DQ, HLA-E, and HLA-G in invasive ductal carcinoma (IDC) of the breast and to relate this HLA profile to anatomopathological parameters. Fifty-two IDC from breast biopsies were stratified according to histological differentiation (well, moderately, and poorly differentiated) and to the presence of metastases in axillary lymph nodes. The expression of HLA molecules was assessed by immunohistochemistry, using a computer-assisted system. Overall, 31 (59.6%) out of the 52 IDC breast biopsies exhibited high expression of HLA-G, but only 14 (26.9%) showed high expression of HLA-E. A large number (41, 78.8%) of the biopsies showed low expression of HLA-Ia, while 45 (86.5%) showed high expression of HLA-DQ and 36 (69.2%) underexpressed HLA-DR. Moreover, 24 (41.2%) of 52 biopsies had both low HLA-Ia expression and high HLA-G expression, while 11 (21.2%) had low HLA-Ia expression and high HLA-E expression. These results suggest that, by different mechanisms, the downregulation of HLA-Ia, HLA-E, and HLA-DR and the upregulation of HLA-G and HLA-DQ are associated with immune response evasion and breast cancer aggressiveness.
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spelling pubmed-38641402013-12-22 Expression of the Classical and Nonclassical HLA Molecules in Breast Cancer da Silva, Gisela Bevilacqua Rolfsen Ferreira Silva, Tarsia Giabardo Alves Duarte, Roberta Aparecida Neto, Nicolino Lia Carrara, Hélio Humberto Angotti Donadi, Eduardo Antônio Gonçalves, Maria Alice Guimarães Soares, Edson Garcia Soares, Christiane Pienna Int J Breast Cancer Research Article Considering that downregulation of HLA expression could represent a potential mechanism for breast carcinogenesis and metastasis, the aim of the present study was to use immunohistochemical methods to analyze the expression of HLA-Ia, HLA-DR, HLA-DQ, HLA-E, and HLA-G in invasive ductal carcinoma (IDC) of the breast and to relate this HLA profile to anatomopathological parameters. Fifty-two IDC from breast biopsies were stratified according to histological differentiation (well, moderately, and poorly differentiated) and to the presence of metastases in axillary lymph nodes. The expression of HLA molecules was assessed by immunohistochemistry, using a computer-assisted system. Overall, 31 (59.6%) out of the 52 IDC breast biopsies exhibited high expression of HLA-G, but only 14 (26.9%) showed high expression of HLA-E. A large number (41, 78.8%) of the biopsies showed low expression of HLA-Ia, while 45 (86.5%) showed high expression of HLA-DQ and 36 (69.2%) underexpressed HLA-DR. Moreover, 24 (41.2%) of 52 biopsies had both low HLA-Ia expression and high HLA-G expression, while 11 (21.2%) had low HLA-Ia expression and high HLA-E expression. These results suggest that, by different mechanisms, the downregulation of HLA-Ia, HLA-E, and HLA-DR and the upregulation of HLA-G and HLA-DQ are associated with immune response evasion and breast cancer aggressiveness. Hindawi Publishing Corporation 2013 2013-12-02 /pmc/articles/PMC3864140/ /pubmed/24363939 http://dx.doi.org/10.1155/2013/250435 Text en Copyright © 2013 Gisela Bevilacqua Rolfsen Ferreira da Silva et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
da Silva, Gisela Bevilacqua Rolfsen Ferreira
Silva, Tarsia Giabardo Alves
Duarte, Roberta Aparecida
Neto, Nicolino Lia
Carrara, Hélio Humberto Angotti
Donadi, Eduardo Antônio
Gonçalves, Maria Alice Guimarães
Soares, Edson Garcia
Soares, Christiane Pienna
Expression of the Classical and Nonclassical HLA Molecules in Breast Cancer
title Expression of the Classical and Nonclassical HLA Molecules in Breast Cancer
title_full Expression of the Classical and Nonclassical HLA Molecules in Breast Cancer
title_fullStr Expression of the Classical and Nonclassical HLA Molecules in Breast Cancer
title_full_unstemmed Expression of the Classical and Nonclassical HLA Molecules in Breast Cancer
title_short Expression of the Classical and Nonclassical HLA Molecules in Breast Cancer
title_sort expression of the classical and nonclassical hla molecules in breast cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3864140/
https://www.ncbi.nlm.nih.gov/pubmed/24363939
http://dx.doi.org/10.1155/2013/250435
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