Cargando…

Live Cell in Vitro and in Vivo Imaging Applications: Accelerating Drug Discovery

Dynamic regulation of specific molecular processes and cellular phenotypes in live cell systems reveal unique insights into cell fate and drug pharmacology that are not gained from traditional fixed endpoint assays. Recent advances in microscopic imaging platform technology combined with the develop...

Descripción completa

Detalles Bibliográficos
Autores principales:	Isherwood, Beverley, Timpson, Paul, McGhee, Ewan J, Anderson, Kurt I, Canel, Marta, Serrels, Alan, Brunton, Valerie G, Carragher, Neil O
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2011
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3864231/ https://www.ncbi.nlm.nih.gov/pubmed/24310493 http://dx.doi.org/10.3390/pharmaceutics3020141

Ejemplares similares

Monitoring the dynamics of Src activity in response to anti-invasive dasatinib treatment at a subcellular level using dual intravital imaging
por: Nobis, Max, et al.
Publicado: (2014)

In vivo imaging of the tumor and its associated microenvironment using combined CARS / 2-photon microscopy
por: Lee, Martin, et al.
Publicado: (2015)

FAK promotes stromal PD-L2 expression associated with poor survival in pancreatic cancer
por: Davidson, Catherine, et al.
Publicado: (2022)

T-cell co-stimulation in combination with targeting FAK drives enhanced anti-tumor immunity
por: Canel, Marta, et al.
Publicado: (2020)

Stimulated Raman scattering microscopy: an emerging tool for drug discovery
por: Tipping, W. J., et al.
Publicado: (2016)

Accelerating glioblastoma drug discovery: Convergence of patient-derived models, genome editing and phenotypic screening
por: O'Duibhir, Eoghan, et al.
Publicado: (2016)

Involvement of focal adhesion kinase in cellular invasion of head and neck squamous cell carcinomas via regulation of MMP-2 expression
por: Canel, M, et al.
Publicado: (2008)

Organotypic Collagen I Assay: A Malleable Platform to Assess Cell Behaviour in a 3-Dimensional Context
por: Timpson, Paul, et al.
Publicado: (2011)

Imaging drug uptake by bioorthogonal stimulated Raman scattering microscopy
por: Tipping, William J., et al.
Publicado: (2017)

Pathway profiling of a novel SRC inhibitor, AZD0424, in combination with MEK inhibitors for cancer treatment
por: Dawson, John C., et al.
Publicado: (2021)

Nuclear FAK Controls Chemokine Transcription, Tregs, and Evasion of Anti-tumor Immunity
por: Serrels, Alan, et al.
Publicado: (2015)

Development of a fluorescence-based cellular apoptosis reporter
por: Balderstone, Lucy A, et al.
Publicado: (2019)

Identification of novel pathways linking epithelial-to-mesenchymal transition with resistance to HER2-targeted therapy
por: Creedon, Helen, et al.
Publicado: (2016)

Accepting from the best donor; analysis of long-lifetime donor fluorescent protein pairings to optimise dynamic FLIM-based FRET experiments
por: Martin, Kirsty J., et al.
Publicado: (2018)

Unusual DNA packaging characteristics in endoreduplicated Caenorhabditis elegans oocytes defined by in vivo accessibility to an endogenous nuclease activity
por: Gu, Sam Guoping, et al.
Publicado: (2013)

Talin tension sensor reveals novel features of focal adhesion force transmission and mechanosensitivity
por: Kumar, Abhishek, et al.
Publicado: (2016)

Correction: Talin tension sensor reveals novel features of focal adhesion force transmission and mechanosensitivity
por: Kumar, Abhishek, et al.
Publicado: (2016)

Abastecimiento de agua y alcantarillado : ingeniería ambiental /
por: McGhee, Terence J.
Publicado: (1999)

THE INFECTION BY PLASMODIUM LOPHURAE OF DUCK ERYTHROCYTES IN THE CHICKEN EMBRYO
por: McGhee, R. Barclay
Publicado: (1953)

Inventario cinco factores de personalidad para niños : FFPI-C /
por: McGhee, Ronnie L.
Publicado: (2019)

Máxima productividad : recupera tu vida usando Microsoft Outlook
por: McGhee, Sally, 1959-
Publicado: (2010)

Kindlin-1 regulates IL-6 secretion and modulates the immune environment in breast cancer models
por: Webb, Emily R, et al.
Publicado: (2023)

Accelerating drug discovery for pregnant and lactating women living with HIV
por: Hoffman, Risa M, et al.
Publicado: (2021)

Polarized Cell Motility Induces Hydrogen Peroxide to Inhibit Cofilin via Cysteine Oxidation
por: Cameron, Jenifer M., et al.
Publicado: (2015)

Partial Differential Equations: A unified Hilbert Space Approach
por: Picard, Rainer, et al.
Publicado: (2011)

Sphere-forming cells from peripheral cornea demonstrate the ability to repopulate the ocular surface
por: Mathan, Jeremy John, et al.
Publicado: (2016)

ROS Production and NF-κB Activation Triggered by RAC1 Facilitate WNT-Driven Intestinal Stem Cell Proliferation and Colorectal Cancer Initiation
por: Myant, Kevin B., et al.
Publicado: (2013)

Exposure to Microbial Metabolite Butyrate Prolongs the Survival Time and Changes the Growth Pattern of Human Papillomavirus 16 E6/E7-Immortalized Keratinocytes in Vivo
por: Li, Mengtao, et al.
Publicado: (2021)

A New In Vivo Screening Paradigm to Accelerate Antimalarial Drug Discovery
por: Jiménez-Díaz, María Belén, et al.
Publicado: (2013)

Accelerating Discovery
por: Spangler, Scott
Publicado: (2015)

Accelerators and discoveries
por: Lee, T D
Publicado: (1983)

FACTORS IN PLASMA CONCERNED IN NATURAL RESISTANCE TO AN AVIAN MALARIA PARASITE (PLASMODIUM LOPHURAE)
por: Trager, William, et al.
Publicado: (1950)

Inside the Mucosal Immune System
por: McGhee, Jerry R., et al.
Publicado: (2012)

Painless project management: a step-by-step guide for planning, executing, and managing projects
por: McGhee, Pamela, et al.
Publicado: (2007)

A cross-sectional study on socioeconomic status and health-related quality of life among elderly Chinese
por: Ma, Xiaoguang, et al.
Publicado: (2013)

Simulation Study of Surface Transfer Doping of Hydrogenated Diamond by MoO(3) and V(2)O(5) Metal Oxides
por: McGhee, Joseph, et al.
Publicado: (2020)

High-Precision Photothermal Ablation Using Biocompatible Palladium Nanoparticles and Laser Scanning Microscopy
por: Rubio-Ruiz, Belén, et al.
Publicado: (2018)

Development of an inducible mouse model of iRFP713 to track recombinase activity and tumour development in vivo
por: Hock, Andreas K., et al.
Publicado: (2017)

Accelerating functional gene discovery in osteoarthritis
por: Butterfield, Natalie C., et al.
Publicado: (2021)

Erwinia amylovora CRISPR Elements Provide New Tools for Evaluating Strain Diversity and for Microbial Source Tracking
por: McGhee, Gayle C., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_36hoe6g2j5c4qrvrgf8vii7tho