Distinct evolutionary trajectories of primary high-grade serous ovarian cancers revealed through spatial mutational profiling

High-grade serous ovarian cancer (HGSC) is characterized by poor outcome, often attributed to the emergence of treatment-resistant subclones. We sought to measure the degree of genomic diversity within primary, untreated HGSCs to examine the natural state of tumour evolution prior to therapy. We per...

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Detalles Bibliográficos
Autores principales: Bashashati, Ali, Ha, Gavin, Tone, Alicia, Ding, Jiarui, Prentice, Leah M, Roth, Andrew, Rosner, Jamie, Shumansky, Karey, Kalloger, Steve, Senz, Janine, Yang, Winnie, McConechy, Melissa, Melnyk, Nataliya, Anglesio, Michael, Luk, Margaret TY, Tse, Kane, Zeng, Thomas, Moore, Richard, Zhao, Yongjun, Marra, Marco A, Gilks, Blake, Yip, Stephen, Huntsman, David G, McAlpine, Jessica N, Shah, Sohrab P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2013
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3864404/
https://www.ncbi.nlm.nih.gov/pubmed/23780408
http://dx.doi.org/10.1002/path.4230

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