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Study of Arachidonic Acid Pathway in Human Bladder Tumor
Recent epidemiological studies and animal experiments have demonstrated that nonsteroidal anti-inflammatory drugs (NSAIDs) reduce the incidence of colorectal carcinoma. Cyclooxygenase (COX) is the principal target of NSAIDs. COX is the first oxidase in the process of prostaglandin production from ar...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Libertas Academica
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3864913/ https://www.ncbi.nlm.nih.gov/pubmed/24357935 |
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author | Matsuyama, Masahide Yoshimura, Rikio |
author_facet | Matsuyama, Masahide Yoshimura, Rikio |
author_sort | Matsuyama, Masahide |
collection | PubMed |
description | Recent epidemiological studies and animal experiments have demonstrated that nonsteroidal anti-inflammatory drugs (NSAIDs) reduce the incidence of colorectal carcinoma. Cyclooxygenase (COX) is the principal target of NSAIDs. COX is the first oxidase in the process of prostaglandin production from arachidonic acid. COX enzyme may be involved in the initiation and/or the promotion of tumorigenesis due to NSAIDs inhibition of COX. Lipoxygenase (LOX) is also an initial enzyme in the pathway for producing leukotrienes from arachidonic acid. Similar to COX, LOX enzyme may also be involved in the initiation and/or promotion of tumorigenesis. Peroxisome proliferator activator-receptor (PPAR)-γ is a ligand-activated transcriptional factor belonging to the steroid receptor superfamily. PPAR-γ plays a role in both adipocyte differentiation and tumorigenesis. PPAR-γ is one target for cell growth modulation of NSAIDs. In this review, we report the expression of COX-2, LOX and PPAR-γ in human bladder tumor tissues as well as the effects of COX-2 and LOX inhibitors and PPAR-γ ligand. |
format | Online Article Text |
id | pubmed-3864913 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Libertas Academica |
record_format | MEDLINE/PubMed |
spelling | pubmed-38649132013-12-19 Study of Arachidonic Acid Pathway in Human Bladder Tumor Matsuyama, Masahide Yoshimura, Rikio Subst Abuse Review Recent epidemiological studies and animal experiments have demonstrated that nonsteroidal anti-inflammatory drugs (NSAIDs) reduce the incidence of colorectal carcinoma. Cyclooxygenase (COX) is the principal target of NSAIDs. COX is the first oxidase in the process of prostaglandin production from arachidonic acid. COX enzyme may be involved in the initiation and/or the promotion of tumorigenesis due to NSAIDs inhibition of COX. Lipoxygenase (LOX) is also an initial enzyme in the pathway for producing leukotrienes from arachidonic acid. Similar to COX, LOX enzyme may also be involved in the initiation and/or promotion of tumorigenesis. Peroxisome proliferator activator-receptor (PPAR)-γ is a ligand-activated transcriptional factor belonging to the steroid receptor superfamily. PPAR-γ plays a role in both adipocyte differentiation and tumorigenesis. PPAR-γ is one target for cell growth modulation of NSAIDs. In this review, we report the expression of COX-2, LOX and PPAR-γ in human bladder tumor tissues as well as the effects of COX-2 and LOX inhibitors and PPAR-γ ligand. Libertas Academica 2009-12-09 /pmc/articles/PMC3864913/ /pubmed/24357935 Text en © 2009 by the authors This article is published under the Creative Commons Attribution By licence. For further information go to: http://creativecommons.org/licenses/by/3.0. |
spellingShingle | Review Matsuyama, Masahide Yoshimura, Rikio Study of Arachidonic Acid Pathway in Human Bladder Tumor |
title | Study of Arachidonic Acid Pathway in Human Bladder Tumor |
title_full | Study of Arachidonic Acid Pathway in Human Bladder Tumor |
title_fullStr | Study of Arachidonic Acid Pathway in Human Bladder Tumor |
title_full_unstemmed | Study of Arachidonic Acid Pathway in Human Bladder Tumor |
title_short | Study of Arachidonic Acid Pathway in Human Bladder Tumor |
title_sort | study of arachidonic acid pathway in human bladder tumor |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3864913/ https://www.ncbi.nlm.nih.gov/pubmed/24357935 |
work_keys_str_mv | AT matsuyamamasahide studyofarachidonicacidpathwayinhumanbladdertumor AT yoshimurarikio studyofarachidonicacidpathwayinhumanbladdertumor |