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Effect of alendronate on bone remodeling around implant in the rat

PURPOSE: The purpose of this study was to evaluate the effect of alendronates on bone remodeling around titanium implant in the maxilla of rats. MATERIALS AND METHODS: The maxillary first molars were extracted and customized-titanium implants were placed immediately in thirty male Sprague-Dawley rat...

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Autores principales: Park, Ran, Kim, Jee-Hwan, Choi, Hyunmin, Park, Young-Bum, Jung, Han-Sung, Moon, Hong-Seok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Academy of Prosthodontics 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3865190/
https://www.ncbi.nlm.nih.gov/pubmed/24353873
http://dx.doi.org/10.4047/jap.2013.5.4.374
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author Park, Ran
Kim, Jee-Hwan
Choi, Hyunmin
Park, Young-Bum
Jung, Han-Sung
Moon, Hong-Seok
author_facet Park, Ran
Kim, Jee-Hwan
Choi, Hyunmin
Park, Young-Bum
Jung, Han-Sung
Moon, Hong-Seok
author_sort Park, Ran
collection PubMed
description PURPOSE: The purpose of this study was to evaluate the effect of alendronates on bone remodeling around titanium implant in the maxilla of rats. MATERIALS AND METHODS: The maxillary first molars were extracted and customized-titanium implants were placed immediately in thirty male Sprague-Dawley rats. The rats were divided into experimental (bisphosphonate) group and control group. At 4 weeks after implantation, the rats in the bisphosphonate group were subcutaneously injected with alendronate three times a week for 6 weeks where as the rats in control group were injected with saline. The rats were sacrificed at 1, 2, 3, 4, or 6 weeks after starting of injection and maxillary bones were collected subsequently. Alveolar bone remodeling around the implants were evaluated by radiographic and histologic analysis. Microarray analysis and immunohistomorphologic analysis were also performed on one rat, sacrificed at 6 weeks after starting of injection, from each group. Statistical analysis was performed using repeated measures analysis of variance and independent t test at a significance level of 5%. RESULTS: There was no statistically significant difference in the bone area (%) around implant between the bisphosphonate group and the control group. However, the amount of empty lacuna was significantly increased in the bisphosphonate group, especially in the rats sacrificed at 4 weeks after starting of injection compared to that of the corresponding control group. The bisphosphonate group showed the same level of TRAP positive cell count, osteocalcin and angiopoietin 1 as the control group. CONCLUSION: Alendronate may not decrease the amount of osteoclast. However, the significantly increased amount of empty lacuna in the bisphosphonate group may explain the suppression of bone remodeling in the bisphosphonate group.
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spelling pubmed-38651902013-12-18 Effect of alendronate on bone remodeling around implant in the rat Park, Ran Kim, Jee-Hwan Choi, Hyunmin Park, Young-Bum Jung, Han-Sung Moon, Hong-Seok J Adv Prosthodont Original Article PURPOSE: The purpose of this study was to evaluate the effect of alendronates on bone remodeling around titanium implant in the maxilla of rats. MATERIALS AND METHODS: The maxillary first molars were extracted and customized-titanium implants were placed immediately in thirty male Sprague-Dawley rats. The rats were divided into experimental (bisphosphonate) group and control group. At 4 weeks after implantation, the rats in the bisphosphonate group were subcutaneously injected with alendronate three times a week for 6 weeks where as the rats in control group were injected with saline. The rats were sacrificed at 1, 2, 3, 4, or 6 weeks after starting of injection and maxillary bones were collected subsequently. Alveolar bone remodeling around the implants were evaluated by radiographic and histologic analysis. Microarray analysis and immunohistomorphologic analysis were also performed on one rat, sacrificed at 6 weeks after starting of injection, from each group. Statistical analysis was performed using repeated measures analysis of variance and independent t test at a significance level of 5%. RESULTS: There was no statistically significant difference in the bone area (%) around implant between the bisphosphonate group and the control group. However, the amount of empty lacuna was significantly increased in the bisphosphonate group, especially in the rats sacrificed at 4 weeks after starting of injection compared to that of the corresponding control group. The bisphosphonate group showed the same level of TRAP positive cell count, osteocalcin and angiopoietin 1 as the control group. CONCLUSION: Alendronate may not decrease the amount of osteoclast. However, the significantly increased amount of empty lacuna in the bisphosphonate group may explain the suppression of bone remodeling in the bisphosphonate group. The Korean Academy of Prosthodontics 2013-11 2013-11-28 /pmc/articles/PMC3865190/ /pubmed/24353873 http://dx.doi.org/10.4047/jap.2013.5.4.374 Text en © 2013 The Korean Academy of Prosthodontics http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Park, Ran
Kim, Jee-Hwan
Choi, Hyunmin
Park, Young-Bum
Jung, Han-Sung
Moon, Hong-Seok
Effect of alendronate on bone remodeling around implant in the rat
title Effect of alendronate on bone remodeling around implant in the rat
title_full Effect of alendronate on bone remodeling around implant in the rat
title_fullStr Effect of alendronate on bone remodeling around implant in the rat
title_full_unstemmed Effect of alendronate on bone remodeling around implant in the rat
title_short Effect of alendronate on bone remodeling around implant in the rat
title_sort effect of alendronate on bone remodeling around implant in the rat
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3865190/
https://www.ncbi.nlm.nih.gov/pubmed/24353873
http://dx.doi.org/10.4047/jap.2013.5.4.374
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