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Co-Expression of SERCA Isoforms, Phospholamban and Sarcolipin in Human Skeletal Muscle Fibers

Sarcolipin (SLN) and phospholamban (PLN) inhibit the activity of sarco(endo)plasmic reticulum Ca(2+)-ATPases (SERCAs) by reducing their apparent affinity for Ca(2+). A ternary complex between SLN, PLN, and SERCAs results in super-inhibition of SERCA activity. Analysis of skeletal muscle homogenate h...

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Detalles Bibliográficos
Autores principales:	Fajardo, Val A., Bombardier, Eric, Vigna, Chris, Devji, Tahira, Bloemberg, Darin, Gamu, Daniel, Gramolini, Anthony O., Quadrilatero, Joe, Tupling, A. Russell
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3865254/ https://www.ncbi.nlm.nih.gov/pubmed/24358354 http://dx.doi.org/10.1371/journal.pone.0084304

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