Intracellular Complement Activation Sustains T Cell Homeostasis and Mediates Effector Differentiation

Complement is viewed as a critical serum-operative component of innate immunity, with processing of its key component, C3, into activation fragments C3a and C3b confined to the extracellular space. We report here that C3 activation also occurred intracellularly. We found that the T cell-expressed pr...

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Detalles Bibliográficos
Autores principales: Liszewski, M. Kathryn, Kolev, Martin, Le Friec, Gaelle, Leung, Marilyn, Bertram, Paula G., Fara, Antonella F., Subias, Marta, Pickering, Matthew C., Drouet, Christian, Meri, Seppo, Arstila, T. Petteri, Pekkarinen, Pirkka T., Ma, Margaret, Cope, Andrew, Reinheckel, Thomas, Rodriguez de Cordoba, Santiago, Afzali, Behdad, Atkinson, John P., Kemper, Claudia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3865363/
https://www.ncbi.nlm.nih.gov/pubmed/24315997
http://dx.doi.org/10.1016/j.immuni.2013.10.018

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