Is memantine a potential therapeutic for Rett syndrome?

Memantine is a low-affinity, voltage-dependent, non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist. It is classified as a neuroprotective aminoadamantane. It does not cure or reverse Alzheimer's but it does effectively treat symptoms, slows the progression of the disease and allows...

Descripción completa

Detalles Bibliográficos
Autores principales: Bello, Olivia, Blair, Kelsey, Chapleau, Christopher, Larimore, Jennifer L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3865366/
https://www.ncbi.nlm.nih.gov/pubmed/24381538
http://dx.doi.org/10.3389/fnins.2013.00245
_version_ 1782296028326658048
author Bello, Olivia
Blair, Kelsey
Chapleau, Christopher
Larimore, Jennifer L.
author_facet Bello, Olivia
Blair, Kelsey
Chapleau, Christopher
Larimore, Jennifer L.
author_sort Bello, Olivia
collection PubMed
description Memantine is a low-affinity, voltage-dependent, non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist. It is classified as a neuroprotective aminoadamantane. It does not cure or reverse Alzheimer's but it does effectively treat symptoms, slows the progression of the disease and allows many patients to perform daily cognitive activities with clear thoughts. Based on it's success in patients with Alzheimer's, memantine has been tested in other neurological disorders with impaired learning and memory. In this review, we will discuss the success and failures of memantine in Downs Syndrome and Fragile X research and from those results, assess the potential benefit of memantine in Rett Syndrome (RTT).
format Online
Article
Text
id pubmed-3865366
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-38653662013-12-31 Is memantine a potential therapeutic for Rett syndrome? Bello, Olivia Blair, Kelsey Chapleau, Christopher Larimore, Jennifer L. Front Neurosci Pharmacology Memantine is a low-affinity, voltage-dependent, non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist. It is classified as a neuroprotective aminoadamantane. It does not cure or reverse Alzheimer's but it does effectively treat symptoms, slows the progression of the disease and allows many patients to perform daily cognitive activities with clear thoughts. Based on it's success in patients with Alzheimer's, memantine has been tested in other neurological disorders with impaired learning and memory. In this review, we will discuss the success and failures of memantine in Downs Syndrome and Fragile X research and from those results, assess the potential benefit of memantine in Rett Syndrome (RTT). Frontiers Media S.A. 2013-12-17 /pmc/articles/PMC3865366/ /pubmed/24381538 http://dx.doi.org/10.3389/fnins.2013.00245 Text en Copyright © 2013 Bello, Blair, Chapleau and Larimore. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Bello, Olivia
Blair, Kelsey
Chapleau, Christopher
Larimore, Jennifer L.
Is memantine a potential therapeutic for Rett syndrome?
title Is memantine a potential therapeutic for Rett syndrome?
title_full Is memantine a potential therapeutic for Rett syndrome?
title_fullStr Is memantine a potential therapeutic for Rett syndrome?
title_full_unstemmed Is memantine a potential therapeutic for Rett syndrome?
title_short Is memantine a potential therapeutic for Rett syndrome?
title_sort is memantine a potential therapeutic for rett syndrome?
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3865366/
https://www.ncbi.nlm.nih.gov/pubmed/24381538
http://dx.doi.org/10.3389/fnins.2013.00245
work_keys_str_mv AT belloolivia ismemantineapotentialtherapeuticforrettsyndrome
AT blairkelsey ismemantineapotentialtherapeuticforrettsyndrome
AT chapleauchristopher ismemantineapotentialtherapeuticforrettsyndrome
AT larimorejenniferl ismemantineapotentialtherapeuticforrettsyndrome

Ejemplares similares