Cargando…

Synergy against PML-RARa: targeting transcription, proteolysis, differentiation, and self-renewal in acute promyelocytic leukemia

Acute promyelocytic leukemia (APL) is a hematological malignancy driven by a chimeric oncoprotein containing the C terminus of the retinoic acid receptor-a (RARa) fused to an N-terminal partner, most commonly promyelocytic leukemia protein (PML). Mechanistically, PML-RARa acts as a transcriptional r...

Descripción completa

Detalles Bibliográficos
Autores principales:	dos Santos, Guilherme Augusto, Kats, Lev, Pandolfi, Pier Paolo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2013
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3865469/ https://www.ncbi.nlm.nih.gov/pubmed/24344243 http://dx.doi.org/10.1084/jem.20131121

Ejemplares similares

Educational Case: Acute Promyelocytic Leukemia With PML-RARA
por: Kunak, Rebecca L., et al.
Publicado: (2019)

Absolute quantification of the pretreatment PML-RARA transcript defines the relapse risk in acute promyelocytic leukemia
por: Albano, Francesco, et al.
Publicado: (2015)

Molecular methods for genomic analyses of variant PML-RARA or other RARA-related chromosomal translocations in acute promyelocytic leukemia
por: Kim, Min Jin, et al.
Publicado: (2012)

Characterization of cryptic rearrangements, deletion, complex variants of PML, RARA in acute promyelocytic leukemia
por: Amare, Pratibha Kadam, et al.
Publicado: (2011)

PML-RARA Fusion Transcripts Detectable 8 Months prior to Promyelocytic Blast Crisis in Chronic Myeloid Leukemia
por: Wolanin, Stephanie, et al.
Publicado: (2020)

PML/RARa Interferes with NRF2 Transcriptional Activity Increasing the Sensitivity to Ascorbate of Acute Promyelocytic Leukemia Cells
por: Banella, Cristina, et al.
Publicado: (2019)

HNRNPC-RARA Fusion Gene in a Case with Acute Promyelocytic Leukemia Lacking PML-RARA Rearrangement Presenting with Abundant Hemophagocytosis
por: Tan, Jing, et al.
Publicado: (2023)

Cytogenetically cryptic PML::RARA fusion in acute promyelocytic leukemia: Testing strategies in the modern era
por: Karlin, Kirill, et al.
Publicado: (2022)

Role of Promyelocytic Leukemia (Pml) Protein in Tumor Suppression
por: Rego, Eduardo M., et al.
Publicado: (2001)

Chromosomal abnormality of acute promyelocytic leukemia other than PML-RARA: a case report of acute promyelocytic leukemia with del(5q)
por: Imataki, Osamu, et al.
Publicado: (2016)

High-Risk Microgranular Acute Promyelocytic Leukemia with a Five-Way Complex Translocation Involving PML-RARA
por: Powers, Benjamin, et al.
Publicado: (2015)

Identification of the novel deletion-type PML-RARA mutation associated with the retinoic acid resistance in acute promyelocytic leukemia
por: Hattori, Hikaru, et al.
Publicado: (2018)

Acute Promyelocytic Leukemia: A Constellation of Molecular Events around a Single PML-RARA Fusion Gene
por: Liquori, Alessandro, et al.
Publicado: (2020)

The PML-RARA fusion is not detectable in historical blood samples of acute promyelocytic leukaemia patients
por: Dunn, William G., et al.
Publicado: (2021)

The increased expression of 14q32 small nucleolar RNA transcripts in promyelocytic leukemia cells is not dependent on PML–RARA fusion gene
por: Cohen, Y, et al.
Publicado: (2012)

Expression and Function of PML-RARA in the Hematopoietic Progenitor Cells of Ctsg-PML-RARA Mice
por: Wartman, Lukas D., et al.
Publicado: (2012)

Promyelocytic Leukemia Protein (Pml) and Daxx Participate in a Novel Nuclear Pathway for Apoptosis
por: Zhong, Sue, et al.
Publicado: (2000)

Flow cytometric immunobead assay for fast and easy detection of PML–RARA fusion proteins for the diagnosis of acute promyelocytic leukemia
por: Dekking, E H A, et al.
Publicado: (2012)

Multi-omics and machine learning reveal context-specific gene regulatory activities of PML::RARA in acute promyelocytic leukemia
por: Villiers, William, et al.
Publicado: (2023)

PML/RARa inhibits PTEN expression in hematopoietic cells by competing with PU.1 transcriptional activity
por: Noguera, Nélida Inés, et al.
Publicado: (2016)

PML–RARA-RXR Oligomers Mediate Retinoid and Rexinoid/cAMP Cross-Talk in Acute Promyelocytic Leukemia Cell Differentiation
por: Kamashev, Dmitrii, et al.
Publicado: (2004)

Acute promyelocytic leukemia with a cryptic insertion of RARA into PML on chromosome 15 due to uniparental isodisomy: A case report
por: Venci, Anna, et al.
Publicado: (2017)

Case Report: Co-existence of a novel EXOC4‐TRHDE gene fusion with PML-RARA in acute promyelocytic leukemia
por: Liu, Xiaodong, et al.
Publicado: (2023)

A complex translocation (1;17;15) with spliced short-type PML-RARA fusion transcripts in acute promyelocytic leukemia: A case report
por: Lv, Lili, et al.
Publicado: (2019)

Early Detection of t(8;21) Chromosomal Translocations During Treatment of PML-RARA Positive Acute Promyelocytic Leukemia: A Case Study
por: Neto, Walter Kleine, et al.
Publicado: (2010)

Development and Validation of a 3-Plex RT-qPCR Assay for the Simultaneous Detection and Quantitation of the Three PML-RARa Fusion Transcripts in Acute Promyelocytic Leukemia
por: Chen, Zhanguo, et al.
Publicado: (2015)

FISH Detection of PML-RARA Fusion in ins(15;17) Acute Promyelocytic Leukaemia Depends on Probe Size
por: Campbell, Lynda J., et al.
Publicado: (2013)

HIF factors cooperate with PML-RARα to promote acute promyelocytic leukemia progression and relapse
por: Coltella, Nadia, et al.
Publicado: (2014)

Role of Promyelocytic Leukemia (Pml) Sumolation in Nuclear Body Formation, 11s Proteasome Recruitment, and as(2)O(3)-Induced Pml or Pml/Retinoic Acid Receptor α Degradation
por: Lallemand-Breitenbach, Valérie, et al.
Publicado: (2001)

Acute promyelocytic leukemia, arsenic, and PML bodies
por: de Thé, Hugues, et al.
Publicado: (2012)

Development of Flow Cytometry-Fluorescent In Situ Hybridization (Flow-FISH) Method for Detection of PML/RARa Chromosomal Translocation in Acute Promyelocytic Leukemia Cell Line
por: Zahedipour, Fatemeh, et al.
Publicado: (2017)

The p97/VCP segregase is essential for arsenic-induced degradation of PML and PML-RARA
por: Jaffray, Ellis G., et al.
Publicado: (2023)

Molecular Profiling: A Case of ZBTB16-RARA Acute Promyelocytic Leukemia
por: Langabeer, Stephen E., et al.
Publicado: (2017)

The DNA Binding Property of PML/RARA but Not the Integrity of PML Nuclear Bodies Is Indispensable for Leukemic Transformation
por: Liu, Xi, et al.
Publicado: (2014)

Promyelocytic Leukemia Protein (PML) Controls Listeria monocytogenes Infection
por: Ribet, David, et al.
Publicado: (2017)

PML-RARA mutations confer varying arsenic trioxide resistance
por: Bai, Dong-Mei, et al.
Publicado: (2016)

Correction: Liquori et al. Acute Promyelocytic Leukemia: A Constellation of Molecular Events around a Single PML-RARA Fusion Gene. Cancers 2020, 12, 624
por: Liquori, Alessandro, et al.
Publicado: (2021)

New variant of acute promyelocytic leukemia with IRF2BP2–RARA fusion
por: Shimomura, Yoshimitsu, et al.
Publicado: (2016)

Promyelocytic Leukemia (PML) gene regulation: implication towards curbing oncogenesis
por: Datta, Neerajana, et al.
Publicado: (2019)

Effects of arsenic on the topology and solubility of promyelocytic leukemia (PML)-nuclear bodies
por: Hirano, Seishiro, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_faughice31m9lfqp9sb2s36luk