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RNA recognition by human TLR8 can lead to autoimmune inflammation

Studies on the role of the RNA receptor TLR8 in inflammation have been limited by its different function in human versus rodents. We have generated multiple lines of transgenic mice expressing different levels of human TLR8. The high copy number chimeras were unable to pass germline; developed sever...

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Detalles Bibliográficos
Autores principales:	Guiducci, Cristiana, Gong, Mei, Cepika, Alma-Martina, Xu, Zhaohui, Tripodo, Claudio, Bennett, Lynda, Crain, Chad, Quartier, Pierre, Cush, John J., Pascual, Virginia, Coffman, Robert L., Barrat, Franck J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3865472/ https://www.ncbi.nlm.nih.gov/pubmed/24277153 http://dx.doi.org/10.1084/jem.20131044

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