IRF4 controls the positioning of mature B cells in the lymphoid microenvironments by regulating NOTCH2 expression and activity

The transcription factor interferon regulatory factor-4 (IRF4) is expressed in B cells at most developmental stages. In antigen-activated B cells, IRF4 controls germinal center formation, class-switch recombination, and the generation of plasma cells. Here we describe a novel function for IRF4 in th...

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Detalles Bibliográficos
Autores principales: Simonetti, Giorgia, Carette, Amanda, Silva, Kathryn, Wang, Haowei, De Silva, Nilushi S., Heise, Nicole, Siebel, Christian W., Shlomchik, Mark J., Klein, Ulf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3865479/
https://www.ncbi.nlm.nih.gov/pubmed/24323359
http://dx.doi.org/10.1084/jem.20131026

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