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Dynorphin B induces lateral asymmetric changes in feline spinal cord reflexes

The effects of dynorphin B (an agonist of κ-opioid receptors) and naloxone (an antagonist of opioid receptors) on the field potentials (FPs) evoked in the lumbar spinal cord of spinalized cats were examined following successive stimulation of pairs of identical peripheral nerves on both sides of the...

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Autores principales: Pilyavskii, Alexander I., Moska, Waldemar, Kochanowicz, Kazimir, Bulgakova, Natalia V., Maznychenko, Andriy V., Vereshchaka, Inna V., Kostyukov, Alexander I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3865526/
https://www.ncbi.nlm.nih.gov/pubmed/24381537
http://dx.doi.org/10.3389/fnins.2013.00244
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author Pilyavskii, Alexander I.
Moska, Waldemar
Kochanowicz, Kazimir
Bulgakova, Natalia V.
Maznychenko, Andriy V.
Vereshchaka, Inna V.
Kostyukov, Alexander I.
author_facet Pilyavskii, Alexander I.
Moska, Waldemar
Kochanowicz, Kazimir
Bulgakova, Natalia V.
Maznychenko, Andriy V.
Vereshchaka, Inna V.
Kostyukov, Alexander I.
author_sort Pilyavskii, Alexander I.
collection PubMed
description The effects of dynorphin B (an agonist of κ-opioid receptors) and naloxone (an antagonist of opioid receptors) on the field potentials (FPs) evoked in the lumbar spinal cord of spinalized cats were examined following successive stimulation of pairs of identical peripheral nerves on both sides of the body. The FPs were recorded bilaterally using microelectrodes from symmetrical sites of the gray matter between the L6 and L7 segments of the spinal cord transected at level of Th11. Significant changes (up to 75%) were registered in the areas of the initial positive components of the FPs evoked by sequential stimulation of the nn. gastrocnemius-soleus, flexor digitorum longus, and tibialis at both hind limbs; a difference between the effects of various nerves was not observed. Two-Way ANOVA analysis showed that two factors, the injection type and recording side, as well as a combination of these factors, strongly influenced the amplitudes of the FPs. Statistically significant side- and injection-dependent differences were registered in the majority of the tests. Both the directions of the changes in the FPs and their relative amplitudes were not strongly connected with a definite side of the spinal cord in different animals. Therefore, it is possible to postulate that the κ-opioid receptors are distributed inhomogeneously over the neuronal populations transmitting the peripheral afferent signals from different hind limbs, thus indicating a possible presence of the lateral asymmetry effects.
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spelling pubmed-38655262013-12-31 Dynorphin B induces lateral asymmetric changes in feline spinal cord reflexes Pilyavskii, Alexander I. Moska, Waldemar Kochanowicz, Kazimir Bulgakova, Natalia V. Maznychenko, Andriy V. Vereshchaka, Inna V. Kostyukov, Alexander I. Front Neurosci Pharmacology The effects of dynorphin B (an agonist of κ-opioid receptors) and naloxone (an antagonist of opioid receptors) on the field potentials (FPs) evoked in the lumbar spinal cord of spinalized cats were examined following successive stimulation of pairs of identical peripheral nerves on both sides of the body. The FPs were recorded bilaterally using microelectrodes from symmetrical sites of the gray matter between the L6 and L7 segments of the spinal cord transected at level of Th11. Significant changes (up to 75%) were registered in the areas of the initial positive components of the FPs evoked by sequential stimulation of the nn. gastrocnemius-soleus, flexor digitorum longus, and tibialis at both hind limbs; a difference between the effects of various nerves was not observed. Two-Way ANOVA analysis showed that two factors, the injection type and recording side, as well as a combination of these factors, strongly influenced the amplitudes of the FPs. Statistically significant side- and injection-dependent differences were registered in the majority of the tests. Both the directions of the changes in the FPs and their relative amplitudes were not strongly connected with a definite side of the spinal cord in different animals. Therefore, it is possible to postulate that the κ-opioid receptors are distributed inhomogeneously over the neuronal populations transmitting the peripheral afferent signals from different hind limbs, thus indicating a possible presence of the lateral asymmetry effects. Frontiers Media S.A. 2013-12-17 /pmc/articles/PMC3865526/ /pubmed/24381537 http://dx.doi.org/10.3389/fnins.2013.00244 Text en Copyright © 2013 Pilyavskii, Moska, Kochanowicz, Bulgakova, Maznychenko, Vereshchaka and Kostyukov. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Pilyavskii, Alexander I.
Moska, Waldemar
Kochanowicz, Kazimir
Bulgakova, Natalia V.
Maznychenko, Andriy V.
Vereshchaka, Inna V.
Kostyukov, Alexander I.
Dynorphin B induces lateral asymmetric changes in feline spinal cord reflexes
title Dynorphin B induces lateral asymmetric changes in feline spinal cord reflexes
title_full Dynorphin B induces lateral asymmetric changes in feline spinal cord reflexes
title_fullStr Dynorphin B induces lateral asymmetric changes in feline spinal cord reflexes
title_full_unstemmed Dynorphin B induces lateral asymmetric changes in feline spinal cord reflexes
title_short Dynorphin B induces lateral asymmetric changes in feline spinal cord reflexes
title_sort dynorphin b induces lateral asymmetric changes in feline spinal cord reflexes
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3865526/
https://www.ncbi.nlm.nih.gov/pubmed/24381537
http://dx.doi.org/10.3389/fnins.2013.00244
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