Systems biology approaches for the study of multiple sclerosis

Multiple sclerosis (MS) is a progressive neurological disease caused by an autoimmune attack to the central nervous system (CNS). MS is thought to result from a complex interaction between genetic and environmental factors. In this review, we analyse the contribution of genomics, trancriptomics and...

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Detalles Bibliográficos
Autores principales: Quintana, Francisco J, Farez, Mauricio F, Weiner, Howard L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2008
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3865652/
https://www.ncbi.nlm.nih.gov/pubmed/18505469
http://dx.doi.org/10.1111/j.1582-4934.2008.00375.x
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author Quintana, Francisco J
Farez, Mauricio F
Weiner, Howard L
author_facet Quintana, Francisco J
Farez, Mauricio F
Weiner, Howard L
author_sort Quintana, Francisco J
collection PubMed
description Multiple sclerosis (MS) is a progressive neurological disease caused by an autoimmune attack to the central nervous system (CNS). MS is thought to result from a complex interaction between genetic and environmental factors. In this review, we analyse the contribution of genomics, trancriptomics and proteomics in delineating these factors, as well as their utility for the monitoring of disease progression, the identification of new targets for therapeutic intervention and the early detection of individuals at risk.
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spelling pubmed-38656522015-04-27 Systems biology approaches for the study of multiple sclerosis Quintana, Francisco J Farez, Mauricio F Weiner, Howard L J Cell Mol Med Reviews Multiple sclerosis (MS) is a progressive neurological disease caused by an autoimmune attack to the central nervous system (CNS). MS is thought to result from a complex interaction between genetic and environmental factors. In this review, we analyse the contribution of genomics, trancriptomics and proteomics in delineating these factors, as well as their utility for the monitoring of disease progression, the identification of new targets for therapeutic intervention and the early detection of individuals at risk. Blackwell Publishing Ltd 2008-08 2008-05-26 /pmc/articles/PMC3865652/ /pubmed/18505469 http://dx.doi.org/10.1111/j.1582-4934.2008.00375.x Text en © 2008 The Authors Journal compilation © 2008 Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd http://creativecommons.org/licenses/by/2.5/ Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.
spellingShingle Reviews
Quintana, Francisco J
Farez, Mauricio F
Weiner, Howard L
Systems biology approaches for the study of multiple sclerosis
title Systems biology approaches for the study of multiple sclerosis
title_full Systems biology approaches for the study of multiple sclerosis
title_fullStr Systems biology approaches for the study of multiple sclerosis
title_full_unstemmed Systems biology approaches for the study of multiple sclerosis
title_short Systems biology approaches for the study of multiple sclerosis
title_sort systems biology approaches for the study of multiple sclerosis
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3865652/
https://www.ncbi.nlm.nih.gov/pubmed/18505469
http://dx.doi.org/10.1111/j.1582-4934.2008.00375.x
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