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Roles of interstitial cells of Cajal in regulating gastrointestinal motility: in vitro versus in vivo studies
The aim of this article is to provide a better understanding of the roles of interstitial cells of Cajal (ICC) in regulating gastrointestinal motility by reviewing in vitro and in vivo physiological motility studies. Based on the in vitro studies, ICC are proposed to have the following functions: to...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3865654/ https://www.ncbi.nlm.nih.gov/pubmed/18429936 http://dx.doi.org/10.1111/j.1582-4934.2008.00352.x |
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author | Yin, Jieyun Chen, Jiande DZ |
author_facet | Yin, Jieyun Chen, Jiande DZ |
author_sort | Yin, Jieyun |
collection | PubMed |
description | The aim of this article is to provide a better understanding of the roles of interstitial cells of Cajal (ICC) in regulating gastrointestinal motility by reviewing in vitro and in vivo physiological motility studies. Based on the in vitro studies, ICC are proposed to have the following functions: to generate slow waves, to mediate neurotransmission between the enteric nerves and the gastrointestinal muscles and to act as mechanoreceptors. However, there is limited evidence available for these hypotheses from the in vivo motility studies. In this review, we first introduce the major subtypes of ICC and their established functions. Three Kit mutant mouse and rodent models are presented and the loss of ICC subtypes in these mutants is reviewed. The physiological motility findings from various in vitroand in vivo experiments are discussed to give a critical review on the roles of ICC in generating slow waves, regulating gastrointestinal motility, mediating neural transmission and serving as mechanoreceptors. It is concluded that the role of ICC as pacemakers may be well established, but other cells may also be involved in the generation of slow waves; the theory that ICC are mediators of neurotransmission is challenged by the majority of the in vivo motility studies; the hypothesis that ICC are mechanoreceptors has not found supportive evidence from the in vivo studies yet. More studies are needed to explain discrepancies in motility findings between the in vitro and in vivo experiments. |
format | Online Article Text |
id | pubmed-3865654 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | Blackwell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-38656542015-04-27 Roles of interstitial cells of Cajal in regulating gastrointestinal motility: in vitro versus in vivo studies Yin, Jieyun Chen, Jiande DZ J Cell Mol Med Reviews The aim of this article is to provide a better understanding of the roles of interstitial cells of Cajal (ICC) in regulating gastrointestinal motility by reviewing in vitro and in vivo physiological motility studies. Based on the in vitro studies, ICC are proposed to have the following functions: to generate slow waves, to mediate neurotransmission between the enteric nerves and the gastrointestinal muscles and to act as mechanoreceptors. However, there is limited evidence available for these hypotheses from the in vivo motility studies. In this review, we first introduce the major subtypes of ICC and their established functions. Three Kit mutant mouse and rodent models are presented and the loss of ICC subtypes in these mutants is reviewed. The physiological motility findings from various in vitroand in vivo experiments are discussed to give a critical review on the roles of ICC in generating slow waves, regulating gastrointestinal motility, mediating neural transmission and serving as mechanoreceptors. It is concluded that the role of ICC as pacemakers may be well established, but other cells may also be involved in the generation of slow waves; the theory that ICC are mediators of neurotransmission is challenged by the majority of the in vivo motility studies; the hypothesis that ICC are mechanoreceptors has not found supportive evidence from the in vivo studies yet. More studies are needed to explain discrepancies in motility findings between the in vitro and in vivo experiments. Blackwell Publishing Ltd 2008-08 2008-04-18 /pmc/articles/PMC3865654/ /pubmed/18429936 http://dx.doi.org/10.1111/j.1582-4934.2008.00352.x Text en © 2008 The Authors Journal compilation © 2008 Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd http://creativecommons.org/licenses/by/2.5/ Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation. |
spellingShingle | Reviews Yin, Jieyun Chen, Jiande DZ Roles of interstitial cells of Cajal in regulating gastrointestinal motility: in vitro versus in vivo studies |
title | Roles of interstitial cells of Cajal in regulating gastrointestinal motility: in vitro versus in vivo studies |
title_full | Roles of interstitial cells of Cajal in regulating gastrointestinal motility: in vitro versus in vivo studies |
title_fullStr | Roles of interstitial cells of Cajal in regulating gastrointestinal motility: in vitro versus in vivo studies |
title_full_unstemmed | Roles of interstitial cells of Cajal in regulating gastrointestinal motility: in vitro versus in vivo studies |
title_short | Roles of interstitial cells of Cajal in regulating gastrointestinal motility: in vitro versus in vivo studies |
title_sort | roles of interstitial cells of cajal in regulating gastrointestinal motility: in vitro versus in vivo studies |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3865654/ https://www.ncbi.nlm.nih.gov/pubmed/18429936 http://dx.doi.org/10.1111/j.1582-4934.2008.00352.x |
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