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Neuroprotective Function of 14-3-3 Proteins in Neurodegeneration
14-3-3 proteins are abundantly expressed adaptor proteins that interact with a vast number of binding partners to regulate their cellular localization and function. They regulate substrate function in a number of ways including protection from dephosphorylation, regulation of enzyme activity, format...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3865737/ https://www.ncbi.nlm.nih.gov/pubmed/24364034 http://dx.doi.org/10.1155/2013/564534 |
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author | Shimada, Tadayuki Fournier, Alyson E. Yamagata, Kanato |
author_facet | Shimada, Tadayuki Fournier, Alyson E. Yamagata, Kanato |
author_sort | Shimada, Tadayuki |
collection | PubMed |
description | 14-3-3 proteins are abundantly expressed adaptor proteins that interact with a vast number of binding partners to regulate their cellular localization and function. They regulate substrate function in a number of ways including protection from dephosphorylation, regulation of enzyme activity, formation of ternary complexes and sequestration. The diversity of 14-3-3 interacting partners thus enables 14-3-3 proteins to impact a wide variety of cellular and physiological processes. 14-3-3 proteins are broadly expressed in the brain, and clinical and experimental studies have implicated 14-3-3 proteins in neurodegenerative disease. A recurring theme is that 14-3-3 proteins play important roles in pathogenesis through regulating the subcellular localization of target proteins. Here, we review the evidence that 14-3-3 proteins regulate aspects of neurodegenerative disease with a focus on their protective roles against neurodegeneration. |
format | Online Article Text |
id | pubmed-3865737 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-38657372013-12-22 Neuroprotective Function of 14-3-3 Proteins in Neurodegeneration Shimada, Tadayuki Fournier, Alyson E. Yamagata, Kanato Biomed Res Int Review Article 14-3-3 proteins are abundantly expressed adaptor proteins that interact with a vast number of binding partners to regulate their cellular localization and function. They regulate substrate function in a number of ways including protection from dephosphorylation, regulation of enzyme activity, formation of ternary complexes and sequestration. The diversity of 14-3-3 interacting partners thus enables 14-3-3 proteins to impact a wide variety of cellular and physiological processes. 14-3-3 proteins are broadly expressed in the brain, and clinical and experimental studies have implicated 14-3-3 proteins in neurodegenerative disease. A recurring theme is that 14-3-3 proteins play important roles in pathogenesis through regulating the subcellular localization of target proteins. Here, we review the evidence that 14-3-3 proteins regulate aspects of neurodegenerative disease with a focus on their protective roles against neurodegeneration. Hindawi Publishing Corporation 2013 2013-12-02 /pmc/articles/PMC3865737/ /pubmed/24364034 http://dx.doi.org/10.1155/2013/564534 Text en Copyright © 2013 Tadayuki Shimada et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Shimada, Tadayuki Fournier, Alyson E. Yamagata, Kanato Neuroprotective Function of 14-3-3 Proteins in Neurodegeneration |
title | Neuroprotective Function of 14-3-3 Proteins in Neurodegeneration |
title_full | Neuroprotective Function of 14-3-3 Proteins in Neurodegeneration |
title_fullStr | Neuroprotective Function of 14-3-3 Proteins in Neurodegeneration |
title_full_unstemmed | Neuroprotective Function of 14-3-3 Proteins in Neurodegeneration |
title_short | Neuroprotective Function of 14-3-3 Proteins in Neurodegeneration |
title_sort | neuroprotective function of 14-3-3 proteins in neurodegeneration |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3865737/ https://www.ncbi.nlm.nih.gov/pubmed/24364034 http://dx.doi.org/10.1155/2013/564534 |
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