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Neuroprotective Function of 14-3-3 Proteins in Neurodegeneration

14-3-3 proteins are abundantly expressed adaptor proteins that interact with a vast number of binding partners to regulate their cellular localization and function. They regulate substrate function in a number of ways including protection from dephosphorylation, regulation of enzyme activity, format...

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Detalles Bibliográficos
Autores principales: Shimada, Tadayuki, Fournier, Alyson E., Yamagata, Kanato
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3865737/
https://www.ncbi.nlm.nih.gov/pubmed/24364034
http://dx.doi.org/10.1155/2013/564534
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author Shimada, Tadayuki
Fournier, Alyson E.
Yamagata, Kanato
author_facet Shimada, Tadayuki
Fournier, Alyson E.
Yamagata, Kanato
author_sort Shimada, Tadayuki
collection PubMed
description 14-3-3 proteins are abundantly expressed adaptor proteins that interact with a vast number of binding partners to regulate their cellular localization and function. They regulate substrate function in a number of ways including protection from dephosphorylation, regulation of enzyme activity, formation of ternary complexes and sequestration. The diversity of 14-3-3 interacting partners thus enables 14-3-3 proteins to impact a wide variety of cellular and physiological processes. 14-3-3 proteins are broadly expressed in the brain, and clinical and experimental studies have implicated 14-3-3 proteins in neurodegenerative disease. A recurring theme is that 14-3-3 proteins play important roles in pathogenesis through regulating the subcellular localization of target proteins. Here, we review the evidence that 14-3-3 proteins regulate aspects of neurodegenerative disease with a focus on their protective roles against neurodegeneration.
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spelling pubmed-38657372013-12-22 Neuroprotective Function of 14-3-3 Proteins in Neurodegeneration Shimada, Tadayuki Fournier, Alyson E. Yamagata, Kanato Biomed Res Int Review Article 14-3-3 proteins are abundantly expressed adaptor proteins that interact with a vast number of binding partners to regulate their cellular localization and function. They regulate substrate function in a number of ways including protection from dephosphorylation, regulation of enzyme activity, formation of ternary complexes and sequestration. The diversity of 14-3-3 interacting partners thus enables 14-3-3 proteins to impact a wide variety of cellular and physiological processes. 14-3-3 proteins are broadly expressed in the brain, and clinical and experimental studies have implicated 14-3-3 proteins in neurodegenerative disease. A recurring theme is that 14-3-3 proteins play important roles in pathogenesis through regulating the subcellular localization of target proteins. Here, we review the evidence that 14-3-3 proteins regulate aspects of neurodegenerative disease with a focus on their protective roles against neurodegeneration. Hindawi Publishing Corporation 2013 2013-12-02 /pmc/articles/PMC3865737/ /pubmed/24364034 http://dx.doi.org/10.1155/2013/564534 Text en Copyright © 2013 Tadayuki Shimada et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Shimada, Tadayuki
Fournier, Alyson E.
Yamagata, Kanato
Neuroprotective Function of 14-3-3 Proteins in Neurodegeneration
title Neuroprotective Function of 14-3-3 Proteins in Neurodegeneration
title_full Neuroprotective Function of 14-3-3 Proteins in Neurodegeneration
title_fullStr Neuroprotective Function of 14-3-3 Proteins in Neurodegeneration
title_full_unstemmed Neuroprotective Function of 14-3-3 Proteins in Neurodegeneration
title_short Neuroprotective Function of 14-3-3 Proteins in Neurodegeneration
title_sort neuroprotective function of 14-3-3 proteins in neurodegeneration
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3865737/
https://www.ncbi.nlm.nih.gov/pubmed/24364034
http://dx.doi.org/10.1155/2013/564534
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