Exploration of a Series of 5-Arylidene-2-thioxoimidazolidin-4-ones as Inhibitors of the Cytolytic Protein Perforin

[Image: see text] A series of novel 5-arylidene-2-thioxoimidazolidin-4-ones were investigated as inhibitors of the lymphocyte-expressed pore-forming protein perforin. Structure–activity relationships were explored through variation of an isoindolinone or 3,4-dihydroisoquinolinone subunit on a fixed...

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Detalles Bibliográficos
Autores principales: Spicer, Julie A., Lena, Gersande, Lyons, Dani M., Huttunen, Kristiina M., Miller, Christian K., O’Connor, Patrick D., Bull, Matthew, Helsby, Nuala, Jamieson, Stephen M. F., Denny, William A., Ciccone, Annette, Browne, Kylie A., Lopez, Jamie A., Rudd-Schmidt, Jesse, Voskoboinik, Ilia, Trapani, Joseph A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2013
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3865801/
https://www.ncbi.nlm.nih.gov/pubmed/24195776
http://dx.doi.org/10.1021/jm401604x

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