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Efficicent (R)-Phenylethanol Production with Enantioselectivity-Alerted (S)-Carbonyl Reductase II and NADPH Regeneration

The NADPH-dependent (S)-carbonyl reductaseII from Candida parapsilosis catalyzes acetophenone to chiral phenylethanol in a very low yield of 3.2%. Site-directed mutagenesis was used to design two mutants Ala220Asp and Glu228Ser, inside or adjacent to the substrate-binding pocket. Both mutations caus...

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Detalles Bibliográficos
Autores principales:	Zhang, Rongzhen, Zhang, Botao, Xu, Yan, Li, Yaohui, Li, Ming, Liang, Hongbo, Xiao, Rong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3866161/ https://www.ncbi.nlm.nih.gov/pubmed/24358299 http://dx.doi.org/10.1371/journal.pone.0083586

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