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Hepatic SH2B1 and SH2B2 Regulate Liver Lipid Metabolism and VLDL Secretion in Mice

SH2B1 is an SH2 and PH domain-containing adaptor protein. Genetic deletion of SH2B1 results in obesity, type 2 diabetes, and fatty liver diseases in mice. Mutations in SH2B1 are linked to obesity in humans. SH2B1 in the brain controls energy balance and body weight at least in part by enhancing lept...

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Detalles Bibliográficos
Autores principales:	Sheng, Liang, Liu, Yan, Jiang, Lin, Chen, Zheng, Zhou, Yingjiang, Cho, Kae Won, Rui, Liangyou
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3866185/ https://www.ncbi.nlm.nih.gov/pubmed/24358267 http://dx.doi.org/10.1371/journal.pone.0083269

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