Cargando…

Polymorphisms of CYP51A1 from Cholesterol Synthesis: Associations with Birth Weight and Maternal Lipid Levels and Impact on CYP51 Protein Structure

We investigated the housekeeping cytochrome P450 CYP51A1 encoding lanosterol 14α-demethylase from cholesterol synthesis that was so far not directly linked to human disorders. By direct sequencing of CYP51A1 in 188 women with spontaneous preterm delivery and 188 unrelated preterm infants (gestationa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lewińska, Monika, Zelenko, Urska, Merzel, Franci, Golic Grdadolnik, Simona, Murray, Jeffrey C., Rozman, Damjana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3866192/ https://www.ncbi.nlm.nih.gov/pubmed/24358204 http://dx.doi.org/10.1371/journal.pone.0082554

Ejemplares similares

Evaluation of Selected CYP51A1 Polymorphisms in View of Interactions with Substrate and Redox Partner
por: Režen, Tadeja, et al.
Publicado: (2017)

Hidden Disease Susceptibility and Sexual Dimorphism in the Heterozygous Knockout of Cyp51 from Cholesterol Synthesis
por: Lewinska, Monika, et al.
Publicado: (2014)

Lessons from Hepatocyte-Specific Cyp51 Knockout Mice: Impaired Cholesterol Synthesis Leads to Oval Cell-Driven Liver Injury
por: Lorbek, Gregor, et al.
Publicado: (2015)

Disrupting Hepatocyte Cyp51 from Cholesterol Synthesis Leads to Progressive Liver Injury in the Developing Mouse and Decreases RORC Signalling
por: Urlep, Žiga, et al.
Publicado: (2017)

Novel structural CYP51 mutation in Trypanosoma cruzi associated with multidrug resistance to CYP51 inhibitors and reduced infectivity
por: Franco, Caio H., et al.
Publicado: (2020)

Analysis of Cyp51 protein sequences shows 4 major Cyp51 gene family groups across fungi
por: Celia-Sanchez, Brandi N, et al.
Publicado: (2022)

Point Mutations in the 14-α Sterol Demethylase Cyp51A or Cyp51C Could Contribute to Azole Resistance in Aspergillus flavus
por: Lucio, Jose, et al.
Publicado: (2020)

Identification of liver CYP51 as a gene responsive to circulating cholesterol in a hamster model
por: Huang, Haiqiu, et al.
Publicado: (2016)

Diverse Inhibitor Chemotypes Targeting Trypanosoma cruzi CYP51
por: Gunatilleke, Shamila S., et al.
Publicado: (2012)

Drug Strategies Targeting CYP51 in Neglected Tropical Diseases
por: Choi, Jun Yong, et al.
Publicado: (2014)

Heterologous expression of the Monilinia fructicola CYP51 (MfCYP51) gene in Pichia pastoris confirms the mode of action of the novel fungicide, SYP-Z048
por: Chen, Fengping, et al.
Publicado: (2015)

Trypanosoma brucei CYP51: Essentiality and Targeting Therapy in an Experimental Model
por: Dauchy, Frédéric-Antoine, et al.
Publicado: (2016)

Study of Azole - Resistant and Cyp51a Gene in Aspergillus Fumigatus
por: Zarrin, Majid, et al.
Publicado: (2018)

The Fungal CYP51s: Their Functions, Structures, Related Drug Resistance, and Inhibitors
por: Zhang, Jingxiang, et al.
Publicado: (2019)

Molecular Dynamics Investigations of Binding Mechanism for Triazoles Inhibitors to CYP51
por: Shi, Na, et al.
Publicado: (2020)

Widespread Occurrence of a CYP51A Pseudogene in Calonectria pseudonaviculata
por: Stravoravdis, Stefanos, et al.
Publicado: (2019)

CYP51 Paralogue Structure Is Associated with Intrinsic Azole Resistance in Fungi
por: Van Rhijn, N., et al.
Publicado: (2021)

Azole Antifungal Sensitivity of Sterol 14α-Demethylase (CYP51) and CYP5218 from Malassezia globosa
por: Warrilow, Andrew G. S., et al.
Publicado: (2016)

Endogenous modulators of neurotrophin signaling: Landscape of the transient ATP-NGF interactions
por: Paoletti, Francesca, et al.
Publicado: (2021)

Identification and Analysis of CYP7A1, CYP17A1, CYP20A1, CYP27A1 and CYP51A1 in Cynomolgus Macaques
por: UNO, Yasuhiro, et al.
Publicado: (2014)

Correction: Trypanosoma brucei CYP51: Essentiality and Targeting Therapy in an Experimental Model
Publicado: (2017)

CYP51 is an essential drug target for the treatment of primary amoebic meningoencephalitis (PAM)
por: Debnath, Anjan, et al.
Publicado: (2017)

Transformation of berberine to its demethylated metabolites by the CYP51 enzyme in the gut microbiota
por: Zhang, Zheng-Wei, et al.
Publicado: (2021)

A Cyp51B Mutation Contributes to Azole Resistance in Aspergillus fumigatus
por: Gonzalez-Jimenez, Irene, et al.
Publicado: (2020)

Interactions of antiparasitic sterols with sterol 14α-demethylase (CYP51) of human pathogens
por: Warfield, Jasmine, et al.
Publicado: (2014)

Differentiation of Aspergillus flavus from Aspergillus oryzae Targeting the cyp51A Gene
por: Nargesi, Sanaz, et al.
Publicado: (2021)

Exploring Cryptococcus neoformans CYP51 and Its Cognate Reductase as a Drug Target
por: Ruma, Yasmeen N., et al.
Publicado: (2022)

CYP51A1 polymorphism and voriconazole-associated hepatotoxicity in children undergoing hematopoietic cell transplant
por: Takahashi, Takuto, et al.
Publicado: (2021)

Trypanosoma cruzi CYP51 Inhibitor Derived from a Mycobacterium tuberculosis Screen Hit
por: Chen, Chiung-Kuang, et al.
Publicado: (2009)

The CYP51F1 Gene of Leptographium qinlingensis: Sequence Characteristic, Phylogeny and Transcript Levels
por: Dai, Lulu, et al.
Publicado: (2015)

Deciphering Aspergillus fumigatus cyp51A-mediated triazole resistance by pyrosequencing of respiratory specimens
por: Novak-Frazer, Lilyann, et al.
Publicado: (2020)

Uncovering New Mutations Conferring Azole Resistance in the Aspergillus fumigatus cyp51A Gene
por: Chen, Peiying, et al.
Publicado: (2020)

Molecular characterization and overexpression of the difenoconazole resistance gene CYP51 in Lasiodiplodia theobromae field isolates
por: Wang, Chenguang, et al.
Publicado: (2021)

Characterisation of Candida parapsilosis CYP51 as a Drug Target Using Saccharomyces cerevisiae as Host
por: Ruma, Yasmeen N., et al.
Publicado: (2022)

Azole Resistance-Associated Regulatory Motifs within the Promoter of cyp51A in Aspergillus fumigatus
por: Kühbacher, Alexander, et al.
Publicado: (2022)

Identification and functional characterization of the CYP51 gene from the yeast Xanthophyllomyces dendrorhous that is involved in ergosterol biosynthesis
por: Leiva, Kritsye, et al.
Publicado: (2015)

Direct Molecular Diagnosis of Aspergillosis and CYP51A Profiling from Respiratory Samples of French Patients
por: Zhao, Yanan, et al.
Publicado: (2016)

Construction of antifungal dual-target (SE, CYP51) pharmacophore models and the discovery of novel antifungal inhibitors
por: Dong, Yue, et al.
Publicado: (2019)

Gene Amplification of CYP51B: a New Mechanism of Resistance to Azole Compounds in Trichophyton indotineae
por: Yamada, Tsuyoshi, et al.
Publicado: (2022)

Azole Resistance and cyp51A Mutation of Aspergillus fumigatus in a Tertiary Referral Hospital in Taiwan
por: Hsu, Tsun-Hao, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_8efvp64js9odobea5sqb376iap