Combining a CD20 Chimeric Antigen Receptor and an Inducible Caspase 9 Suicide Switch to Improve the Efficacy and Safety of T Cell Adoptive Immunotherapy for Lymphoma

Modification of T cells with chimeric antigen receptors (CAR) has emerged as a promising treatment modality for human malignancies. Integration of co-stimulatory domains into CARs can augment the activation and function of genetically targeted T cells against tumors. However, the potential for inser...

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Detalles Bibliográficos
Autores principales: Budde, Lihua E., Berger, Carolina, Lin, Yukang, Wang, Jinjuan, Lin, Xubin, Frayo, Shani E., Brouns, Shaunda A., Spencer, David M., Till, Brian G., Jensen, Michael C., Riddell, Stanley R., Press, Oliver W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3866194/
https://www.ncbi.nlm.nih.gov/pubmed/24358223
http://dx.doi.org/10.1371/journal.pone.0082742

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