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Usefulness of Intracoronary Epinephrine in Severe Hypotension during Percutaneous Coronary Interventions
BACKGROUND AND OBJECTIVES: Life-threatening hypotension during percutaneous coronary interventions (PCI) is devastating for the patient and is associated with fatal adverse outcomes. The aim of our study was to assess the usefulness of intracoronary epinephrine in severe hypotension unresponsive to...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The Korean Society of Cardiology
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3866313/ https://www.ncbi.nlm.nih.gov/pubmed/24363749 http://dx.doi.org/10.4070/kcj.2013.43.11.739 |
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author | Choi, Jin Hee Chun, Kook-Jin Lee, Sang Hyun Chon, Min Ku Lee, Sang-Gwon Kim, Jeong Su Kim, Jun Park, Yong-Hyun Kim, June Hong |
author_facet | Choi, Jin Hee Chun, Kook-Jin Lee, Sang Hyun Chon, Min Ku Lee, Sang-Gwon Kim, Jeong Su Kim, Jun Park, Yong-Hyun Kim, June Hong |
author_sort | Choi, Jin Hee |
collection | PubMed |
description | BACKGROUND AND OBJECTIVES: Life-threatening hypotension during percutaneous coronary interventions (PCI) is devastating for the patient and is associated with fatal adverse outcomes. The aim of our study was to assess the usefulness of intracoronary epinephrine in severe hypotension unresponsive to other measures during PCI. SUBJECTS AND METHODS: We analyzed the Pusan National University Yangsan hospital cardiac catheterization laboratory database to identify patients who underwent PCI from December 2008 to July 2012. The outcomes were changes of blood pressure (BP) and heart rate (HR) before and after intracoronary epinephrine and in-hospital mortality. RESULTS: A total of 30 patients who were initially stable and received intracoronary epinephrine for severe hypotension during PCI were included. Following administration of intracoronary epinephrine (dose 181±24.8 microgram), systolic and diastolic BP (from 53.8±13.0 mm Hg up to 112.8±21.2 mm Hg, from 35±7.6 mm Hg up to 70.6±12.7 mm Hg, respectively) and HR (from 39.4±5.1 beats/min up to 96.8±29.3 beats/min) were increased. Additionally, 21 patients (70%) showed hemodynamically acceptable responses to intracoronary epinephrine without the intraaortic balloon pump and temporary pacemaker during the PCI. In-hospital mortality was 17% (n=5). CONCLUSION: Although our study was small, intracoronary epinephrine was found to be well tolerated and resulted in prompt and successful recovery from severe hypotension in most patients when other measures were ineffective. Intracoronary epinephrine could be a safe and useful measure in patients developing severe hypotension during PCI. |
format | Online Article Text |
id | pubmed-3866313 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | The Korean Society of Cardiology |
record_format | MEDLINE/PubMed |
spelling | pubmed-38663132013-12-20 Usefulness of Intracoronary Epinephrine in Severe Hypotension during Percutaneous Coronary Interventions Choi, Jin Hee Chun, Kook-Jin Lee, Sang Hyun Chon, Min Ku Lee, Sang-Gwon Kim, Jeong Su Kim, Jun Park, Yong-Hyun Kim, June Hong Korean Circ J Original Article BACKGROUND AND OBJECTIVES: Life-threatening hypotension during percutaneous coronary interventions (PCI) is devastating for the patient and is associated with fatal adverse outcomes. The aim of our study was to assess the usefulness of intracoronary epinephrine in severe hypotension unresponsive to other measures during PCI. SUBJECTS AND METHODS: We analyzed the Pusan National University Yangsan hospital cardiac catheterization laboratory database to identify patients who underwent PCI from December 2008 to July 2012. The outcomes were changes of blood pressure (BP) and heart rate (HR) before and after intracoronary epinephrine and in-hospital mortality. RESULTS: A total of 30 patients who were initially stable and received intracoronary epinephrine for severe hypotension during PCI were included. Following administration of intracoronary epinephrine (dose 181±24.8 microgram), systolic and diastolic BP (from 53.8±13.0 mm Hg up to 112.8±21.2 mm Hg, from 35±7.6 mm Hg up to 70.6±12.7 mm Hg, respectively) and HR (from 39.4±5.1 beats/min up to 96.8±29.3 beats/min) were increased. Additionally, 21 patients (70%) showed hemodynamically acceptable responses to intracoronary epinephrine without the intraaortic balloon pump and temporary pacemaker during the PCI. In-hospital mortality was 17% (n=5). CONCLUSION: Although our study was small, intracoronary epinephrine was found to be well tolerated and resulted in prompt and successful recovery from severe hypotension in most patients when other measures were ineffective. Intracoronary epinephrine could be a safe and useful measure in patients developing severe hypotension during PCI. The Korean Society of Cardiology 2013-11 2013-11-30 /pmc/articles/PMC3866313/ /pubmed/24363749 http://dx.doi.org/10.4070/kcj.2013.43.11.739 Text en Copyright © 2013 The Korean Society of Cardiology http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Choi, Jin Hee Chun, Kook-Jin Lee, Sang Hyun Chon, Min Ku Lee, Sang-Gwon Kim, Jeong Su Kim, Jun Park, Yong-Hyun Kim, June Hong Usefulness of Intracoronary Epinephrine in Severe Hypotension during Percutaneous Coronary Interventions |
title | Usefulness of Intracoronary Epinephrine in Severe Hypotension during Percutaneous Coronary Interventions |
title_full | Usefulness of Intracoronary Epinephrine in Severe Hypotension during Percutaneous Coronary Interventions |
title_fullStr | Usefulness of Intracoronary Epinephrine in Severe Hypotension during Percutaneous Coronary Interventions |
title_full_unstemmed | Usefulness of Intracoronary Epinephrine in Severe Hypotension during Percutaneous Coronary Interventions |
title_short | Usefulness of Intracoronary Epinephrine in Severe Hypotension during Percutaneous Coronary Interventions |
title_sort | usefulness of intracoronary epinephrine in severe hypotension during percutaneous coronary interventions |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3866313/ https://www.ncbi.nlm.nih.gov/pubmed/24363749 http://dx.doi.org/10.4070/kcj.2013.43.11.739 |
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