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Functional connectivity of the entorhinal–hippocampal space circuit
The mammalian space circuit is known to contain several functionally specialized cell types, such as place cells in the hippocampus and grid cells, head-direction cells and border cells in the medial entorhinal cortex (MEC). The interaction between the entorhinal and hippocampal spatial representati...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3866440/ https://www.ncbi.nlm.nih.gov/pubmed/24366130 http://dx.doi.org/10.1098/rstb.2012.0516 |
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author | Zhang, Sheng-Jia Ye, Jing Couey, Jonathan J. Witter, Menno Moser, Edvard I. Moser, May-Britt |
author_facet | Zhang, Sheng-Jia Ye, Jing Couey, Jonathan J. Witter, Menno Moser, Edvard I. Moser, May-Britt |
author_sort | Zhang, Sheng-Jia |
collection | PubMed |
description | The mammalian space circuit is known to contain several functionally specialized cell types, such as place cells in the hippocampus and grid cells, head-direction cells and border cells in the medial entorhinal cortex (MEC). The interaction between the entorhinal and hippocampal spatial representations is poorly understood, however. We have developed an optogenetic strategy to identify functionally defined cell types in the MEC that project directly to the hippocampus. By expressing channelrhodopsin-2 (ChR2) selectively in the hippocampus-projecting subset of entorhinal projection neurons, we were able to use light-evoked discharge as an instrument to determine whether specific entorhinal cell groups—such as grid cells, border cells and head-direction cells—have direct hippocampal projections. Photoinduced firing was observed at fixed minimal latencies in all functional cell categories, with grid cells as the most abundant hippocampus-projecting spatial cell type. We discuss how photoexcitation experiments can be used to distinguish the subset of hippocampus-projecting entorhinal neurons from neurons that are activated indirectly through the network. The functional breadth of entorhinal input implied by this analysis opens up the potential for rich dynamic interactions between place cells in the hippocampus and different functional cell types in the entorhinal cortex (EC). |
format | Online Article Text |
id | pubmed-3866440 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | The Royal Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-38664402014-02-05 Functional connectivity of the entorhinal–hippocampal space circuit Zhang, Sheng-Jia Ye, Jing Couey, Jonathan J. Witter, Menno Moser, Edvard I. Moser, May-Britt Philos Trans R Soc Lond B Biol Sci Part II: Spatial cells: grid, head direction, place and boundary cells The mammalian space circuit is known to contain several functionally specialized cell types, such as place cells in the hippocampus and grid cells, head-direction cells and border cells in the medial entorhinal cortex (MEC). The interaction between the entorhinal and hippocampal spatial representations is poorly understood, however. We have developed an optogenetic strategy to identify functionally defined cell types in the MEC that project directly to the hippocampus. By expressing channelrhodopsin-2 (ChR2) selectively in the hippocampus-projecting subset of entorhinal projection neurons, we were able to use light-evoked discharge as an instrument to determine whether specific entorhinal cell groups—such as grid cells, border cells and head-direction cells—have direct hippocampal projections. Photoinduced firing was observed at fixed minimal latencies in all functional cell categories, with grid cells as the most abundant hippocampus-projecting spatial cell type. We discuss how photoexcitation experiments can be used to distinguish the subset of hippocampus-projecting entorhinal neurons from neurons that are activated indirectly through the network. The functional breadth of entorhinal input implied by this analysis opens up the potential for rich dynamic interactions between place cells in the hippocampus and different functional cell types in the entorhinal cortex (EC). The Royal Society 2014-02-05 /pmc/articles/PMC3866440/ /pubmed/24366130 http://dx.doi.org/10.1098/rstb.2012.0516 Text en http://creativecommons.org/licenses/by/3.0/ © 2013 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/3.0/, which permits unrestricted use, provided the original author and source are credited. |
spellingShingle | Part II: Spatial cells: grid, head direction, place and boundary cells Zhang, Sheng-Jia Ye, Jing Couey, Jonathan J. Witter, Menno Moser, Edvard I. Moser, May-Britt Functional connectivity of the entorhinal–hippocampal space circuit |
title | Functional connectivity of the entorhinal–hippocampal space circuit |
title_full | Functional connectivity of the entorhinal–hippocampal space circuit |
title_fullStr | Functional connectivity of the entorhinal–hippocampal space circuit |
title_full_unstemmed | Functional connectivity of the entorhinal–hippocampal space circuit |
title_short | Functional connectivity of the entorhinal–hippocampal space circuit |
title_sort | functional connectivity of the entorhinal–hippocampal space circuit |
topic | Part II: Spatial cells: grid, head direction, place and boundary cells |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3866440/ https://www.ncbi.nlm.nih.gov/pubmed/24366130 http://dx.doi.org/10.1098/rstb.2012.0516 |
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