The C-terminal extension of Lsm4 interacts directly with the 3′ end of the histone mRNP and is required for efficient histone mRNA degradation

Metazoan replication-dependent histone mRNAs are the only known eukaryotic mRNAs that lack a poly(A) tail, ending instead in a conserved stem–loop sequence, which is bound to the stem–loop binding protein (SLBP) on the histone mRNP. Histone mRNAs are rapidly degraded when DNA synthesis is inhibited...

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Detalles Bibliográficos
Autores principales: Lyons, Shawn M., Ricciardi, Adele S., Guo, Andrew Y., Kambach, Christian, Marzluff, William F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2014
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3866647/
https://www.ncbi.nlm.nih.gov/pubmed/24255165
http://dx.doi.org/10.1261/rna.042531.113

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