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Anti-Müllerian Hormone and Its Clinical Use in Pediatrics with Special Emphasis on Disorders of Sex Development

Using measurements of circulating anti-Müllerian hormone (AMH) in diagnosing and managing reproductive disorders in pediatric patients requires thorough knowledge on normative values according to age and gender. We provide age- and sex-specific reference ranges for the Immunotech assay and conversio...

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Autores principales: Lindhardt Johansen, Marie, Hagen, Casper P., Johannsen, Trine Holm, Main, Katharina M., Picard, Jean-Yves, Jørgensen, Anne, Rajpert-De Meyts, Ewa, Juul, Anders
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3866787/
https://www.ncbi.nlm.nih.gov/pubmed/24367377
http://dx.doi.org/10.1155/2013/198698
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author Lindhardt Johansen, Marie
Hagen, Casper P.
Johannsen, Trine Holm
Main, Katharina M.
Picard, Jean-Yves
Jørgensen, Anne
Rajpert-De Meyts, Ewa
Juul, Anders
author_facet Lindhardt Johansen, Marie
Hagen, Casper P.
Johannsen, Trine Holm
Main, Katharina M.
Picard, Jean-Yves
Jørgensen, Anne
Rajpert-De Meyts, Ewa
Juul, Anders
author_sort Lindhardt Johansen, Marie
collection PubMed
description Using measurements of circulating anti-Müllerian hormone (AMH) in diagnosing and managing reproductive disorders in pediatric patients requires thorough knowledge on normative values according to age and gender. We provide age- and sex-specific reference ranges for the Immunotech assay and conversion factors for the DSL and Generation II assays. With this tool in hand, the pediatrician can use serum concentrations of AMH when determining the presence of testicular tissue in patients with bilaterally absent testes or more severe Disorders of Sex Development (DSD). Furthermore, AMH can be used as a marker of premature ovarian insufficiency (POI) in both Turner Syndrome patients and in girls with cancer after treatment with alkylating gonadotoxic agents. Lastly, its usefulness has been proposed in the diagnosis of polycystic ovarian syndrome (PCOS) and ovarian granulosa cell tumors and in the evaluation of patients with hypogonadotropic hypogonadism.
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spelling pubmed-38667872013-12-23 Anti-Müllerian Hormone and Its Clinical Use in Pediatrics with Special Emphasis on Disorders of Sex Development Lindhardt Johansen, Marie Hagen, Casper P. Johannsen, Trine Holm Main, Katharina M. Picard, Jean-Yves Jørgensen, Anne Rajpert-De Meyts, Ewa Juul, Anders Int J Endocrinol Review Article Using measurements of circulating anti-Müllerian hormone (AMH) in diagnosing and managing reproductive disorders in pediatric patients requires thorough knowledge on normative values according to age and gender. We provide age- and sex-specific reference ranges for the Immunotech assay and conversion factors for the DSL and Generation II assays. With this tool in hand, the pediatrician can use serum concentrations of AMH when determining the presence of testicular tissue in patients with bilaterally absent testes or more severe Disorders of Sex Development (DSD). Furthermore, AMH can be used as a marker of premature ovarian insufficiency (POI) in both Turner Syndrome patients and in girls with cancer after treatment with alkylating gonadotoxic agents. Lastly, its usefulness has been proposed in the diagnosis of polycystic ovarian syndrome (PCOS) and ovarian granulosa cell tumors and in the evaluation of patients with hypogonadotropic hypogonadism. Hindawi Publishing Corporation 2013 2013-12-03 /pmc/articles/PMC3866787/ /pubmed/24367377 http://dx.doi.org/10.1155/2013/198698 Text en Copyright © 2013 Marie Lindhardt Johansen et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Lindhardt Johansen, Marie
Hagen, Casper P.
Johannsen, Trine Holm
Main, Katharina M.
Picard, Jean-Yves
Jørgensen, Anne
Rajpert-De Meyts, Ewa
Juul, Anders
Anti-Müllerian Hormone and Its Clinical Use in Pediatrics with Special Emphasis on Disorders of Sex Development
title Anti-Müllerian Hormone and Its Clinical Use in Pediatrics with Special Emphasis on Disorders of Sex Development
title_full Anti-Müllerian Hormone and Its Clinical Use in Pediatrics with Special Emphasis on Disorders of Sex Development
title_fullStr Anti-Müllerian Hormone and Its Clinical Use in Pediatrics with Special Emphasis on Disorders of Sex Development
title_full_unstemmed Anti-Müllerian Hormone and Its Clinical Use in Pediatrics with Special Emphasis on Disorders of Sex Development
title_short Anti-Müllerian Hormone and Its Clinical Use in Pediatrics with Special Emphasis on Disorders of Sex Development
title_sort anti-müllerian hormone and its clinical use in pediatrics with special emphasis on disorders of sex development
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3866787/
https://www.ncbi.nlm.nih.gov/pubmed/24367377
http://dx.doi.org/10.1155/2013/198698
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