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Anti-Müllerian Hormone and Its Clinical Use in Pediatrics with Special Emphasis on Disorders of Sex Development
Using measurements of circulating anti-Müllerian hormone (AMH) in diagnosing and managing reproductive disorders in pediatric patients requires thorough knowledge on normative values according to age and gender. We provide age- and sex-specific reference ranges for the Immunotech assay and conversio...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3866787/ https://www.ncbi.nlm.nih.gov/pubmed/24367377 http://dx.doi.org/10.1155/2013/198698 |
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author | Lindhardt Johansen, Marie Hagen, Casper P. Johannsen, Trine Holm Main, Katharina M. Picard, Jean-Yves Jørgensen, Anne Rajpert-De Meyts, Ewa Juul, Anders |
author_facet | Lindhardt Johansen, Marie Hagen, Casper P. Johannsen, Trine Holm Main, Katharina M. Picard, Jean-Yves Jørgensen, Anne Rajpert-De Meyts, Ewa Juul, Anders |
author_sort | Lindhardt Johansen, Marie |
collection | PubMed |
description | Using measurements of circulating anti-Müllerian hormone (AMH) in diagnosing and managing reproductive disorders in pediatric patients requires thorough knowledge on normative values according to age and gender. We provide age- and sex-specific reference ranges for the Immunotech assay and conversion factors for the DSL and Generation II assays. With this tool in hand, the pediatrician can use serum concentrations of AMH when determining the presence of testicular tissue in patients with bilaterally absent testes or more severe Disorders of Sex Development (DSD). Furthermore, AMH can be used as a marker of premature ovarian insufficiency (POI) in both Turner Syndrome patients and in girls with cancer after treatment with alkylating gonadotoxic agents. Lastly, its usefulness has been proposed in the diagnosis of polycystic ovarian syndrome (PCOS) and ovarian granulosa cell tumors and in the evaluation of patients with hypogonadotropic hypogonadism. |
format | Online Article Text |
id | pubmed-3866787 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-38667872013-12-23 Anti-Müllerian Hormone and Its Clinical Use in Pediatrics with Special Emphasis on Disorders of Sex Development Lindhardt Johansen, Marie Hagen, Casper P. Johannsen, Trine Holm Main, Katharina M. Picard, Jean-Yves Jørgensen, Anne Rajpert-De Meyts, Ewa Juul, Anders Int J Endocrinol Review Article Using measurements of circulating anti-Müllerian hormone (AMH) in diagnosing and managing reproductive disorders in pediatric patients requires thorough knowledge on normative values according to age and gender. We provide age- and sex-specific reference ranges for the Immunotech assay and conversion factors for the DSL and Generation II assays. With this tool in hand, the pediatrician can use serum concentrations of AMH when determining the presence of testicular tissue in patients with bilaterally absent testes or more severe Disorders of Sex Development (DSD). Furthermore, AMH can be used as a marker of premature ovarian insufficiency (POI) in both Turner Syndrome patients and in girls with cancer after treatment with alkylating gonadotoxic agents. Lastly, its usefulness has been proposed in the diagnosis of polycystic ovarian syndrome (PCOS) and ovarian granulosa cell tumors and in the evaluation of patients with hypogonadotropic hypogonadism. Hindawi Publishing Corporation 2013 2013-12-03 /pmc/articles/PMC3866787/ /pubmed/24367377 http://dx.doi.org/10.1155/2013/198698 Text en Copyright © 2013 Marie Lindhardt Johansen et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Lindhardt Johansen, Marie Hagen, Casper P. Johannsen, Trine Holm Main, Katharina M. Picard, Jean-Yves Jørgensen, Anne Rajpert-De Meyts, Ewa Juul, Anders Anti-Müllerian Hormone and Its Clinical Use in Pediatrics with Special Emphasis on Disorders of Sex Development |
title | Anti-Müllerian Hormone and Its Clinical Use in Pediatrics with Special Emphasis on Disorders of Sex Development |
title_full | Anti-Müllerian Hormone and Its Clinical Use in Pediatrics with Special Emphasis on Disorders of Sex Development |
title_fullStr | Anti-Müllerian Hormone and Its Clinical Use in Pediatrics with Special Emphasis on Disorders of Sex Development |
title_full_unstemmed | Anti-Müllerian Hormone and Its Clinical Use in Pediatrics with Special Emphasis on Disorders of Sex Development |
title_short | Anti-Müllerian Hormone and Its Clinical Use in Pediatrics with Special Emphasis on Disorders of Sex Development |
title_sort | anti-müllerian hormone and its clinical use in pediatrics with special emphasis on disorders of sex development |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3866787/ https://www.ncbi.nlm.nih.gov/pubmed/24367377 http://dx.doi.org/10.1155/2013/198698 |
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