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TSP-1-1223 A/G Polymorphism as a Potential Predictor of the Recurrence Risk of Bladder Cancer in a Chinese Population
Backgrounds. TSP-1 is a glycoprotein that functions in the biology of bladder cancer. We investigated the relationship between the distribution of TSP-1-1223 A/G polymorphism (rs2169830) and the clinical characteristics of bladder cancer. Materials and Methods. TaqMan assay was performed to determin...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3866825/ https://www.ncbi.nlm.nih.gov/pubmed/24367787 http://dx.doi.org/10.1155/2013/473242 |
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author | Yang, Xiao Li, Pengchao Yang, Xuejian Qin, Chao Cao, Qiang Zhang, Zhengdong Wang, Meilin Cai, Hongzhou Gu, Jinbao Tao, Jun Gu, Min Lu, Qiang Yin, Changjun |
author_facet | Yang, Xiao Li, Pengchao Yang, Xuejian Qin, Chao Cao, Qiang Zhang, Zhengdong Wang, Meilin Cai, Hongzhou Gu, Jinbao Tao, Jun Gu, Min Lu, Qiang Yin, Changjun |
author_sort | Yang, Xiao |
collection | PubMed |
description | Backgrounds. TSP-1 is a glycoprotein that functions in the biology of bladder cancer. We investigated the relationship between the distribution of TSP-1-1223 A/G polymorphism (rs2169830) and the clinical characteristics of bladder cancer. Materials and Methods. TaqMan assay was performed to determine the genotype of 609 cases and 670 control subjects in a Chinese population. Logistic regression was used to assess the association between the polymorphism and the risk of bladder cancer. Quantitative real-time polymerase chain reaction was performed to determine TSP-1 mRNA expression. Survival curves were generated using the Kaplan-Meier method. Results. No significant differences were detected in the genotype frequencies of healthy control subjects and patients with bladder cancer. By contrast, the time until the first recurrence differed significantly between genotypes (P = 0.017). The expression of TSP-1 mRNA in bladder cancer tissues was lower in patients with an AG genotype than in those with an AA genotype. The lowest expression was observed in patients with a GG genotype. Conclusions. In conclusion, TSP-1-1223 A/G polymorphism may contribute to the recurrence of bladder cancer in Chinese population. |
format | Online Article Text |
id | pubmed-3866825 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-38668252013-12-23 TSP-1-1223 A/G Polymorphism as a Potential Predictor of the Recurrence Risk of Bladder Cancer in a Chinese Population Yang, Xiao Li, Pengchao Yang, Xuejian Qin, Chao Cao, Qiang Zhang, Zhengdong Wang, Meilin Cai, Hongzhou Gu, Jinbao Tao, Jun Gu, Min Lu, Qiang Yin, Changjun Int J Genomics Research Article Backgrounds. TSP-1 is a glycoprotein that functions in the biology of bladder cancer. We investigated the relationship between the distribution of TSP-1-1223 A/G polymorphism (rs2169830) and the clinical characteristics of bladder cancer. Materials and Methods. TaqMan assay was performed to determine the genotype of 609 cases and 670 control subjects in a Chinese population. Logistic regression was used to assess the association between the polymorphism and the risk of bladder cancer. Quantitative real-time polymerase chain reaction was performed to determine TSP-1 mRNA expression. Survival curves were generated using the Kaplan-Meier method. Results. No significant differences were detected in the genotype frequencies of healthy control subjects and patients with bladder cancer. By contrast, the time until the first recurrence differed significantly between genotypes (P = 0.017). The expression of TSP-1 mRNA in bladder cancer tissues was lower in patients with an AG genotype than in those with an AA genotype. The lowest expression was observed in patients with a GG genotype. Conclusions. In conclusion, TSP-1-1223 A/G polymorphism may contribute to the recurrence of bladder cancer in Chinese population. Hindawi Publishing Corporation 2013 2013-12-03 /pmc/articles/PMC3866825/ /pubmed/24367787 http://dx.doi.org/10.1155/2013/473242 Text en Copyright © 2013 Xiao Yang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Yang, Xiao Li, Pengchao Yang, Xuejian Qin, Chao Cao, Qiang Zhang, Zhengdong Wang, Meilin Cai, Hongzhou Gu, Jinbao Tao, Jun Gu, Min Lu, Qiang Yin, Changjun TSP-1-1223 A/G Polymorphism as a Potential Predictor of the Recurrence Risk of Bladder Cancer in a Chinese Population |
title |
TSP-1-1223 A/G Polymorphism as a Potential Predictor of the Recurrence Risk of Bladder Cancer in a Chinese Population |
title_full |
TSP-1-1223 A/G Polymorphism as a Potential Predictor of the Recurrence Risk of Bladder Cancer in a Chinese Population |
title_fullStr |
TSP-1-1223 A/G Polymorphism as a Potential Predictor of the Recurrence Risk of Bladder Cancer in a Chinese Population |
title_full_unstemmed |
TSP-1-1223 A/G Polymorphism as a Potential Predictor of the Recurrence Risk of Bladder Cancer in a Chinese Population |
title_short |
TSP-1-1223 A/G Polymorphism as a Potential Predictor of the Recurrence Risk of Bladder Cancer in a Chinese Population |
title_sort | tsp-1-1223 a/g polymorphism as a potential predictor of the recurrence risk of bladder cancer in a chinese population |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3866825/ https://www.ncbi.nlm.nih.gov/pubmed/24367787 http://dx.doi.org/10.1155/2013/473242 |
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