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Risk Factors for Asymptomatic Ventricular Dysfunction in Rheumatoid Arthritis Patients

Objective. The aim of the study was to describe echocardiographic abnormalities in patients with rheumatoid arthritis, concurrent systemic comorbidities, rheumatologic clinical activity, serologic markers of rheumatoid arthritis, and inflammatory activity. Methods. In an observational, cross-section...

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Autores principales: Garza-García, Carlos, Rocío, Sánchez-Santillán, Orea-Tejeda, Arturo, Castillo-Martínez, Lilia, Eduardo, Canseco, López-Campos, José Luis, Keirns-Davis, Candace
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3866864/
https://www.ncbi.nlm.nih.gov/pubmed/24368945
http://dx.doi.org/10.1155/2013/635439
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author Garza-García, Carlos
Rocío, Sánchez-Santillán
Orea-Tejeda, Arturo
Castillo-Martínez, Lilia
Eduardo, Canseco
López-Campos, José Luis
Keirns-Davis, Candace
author_facet Garza-García, Carlos
Rocío, Sánchez-Santillán
Orea-Tejeda, Arturo
Castillo-Martínez, Lilia
Eduardo, Canseco
López-Campos, José Luis
Keirns-Davis, Candace
author_sort Garza-García, Carlos
collection PubMed
description Objective. The aim of the study was to describe echocardiographic abnormalities in patients with rheumatoid arthritis, concurrent systemic comorbidities, rheumatologic clinical activity, serologic markers of rheumatoid arthritis, and inflammatory activity. Methods. In an observational, cross-sectional study, rheumatoid arthritis outpatients were included (n = 105). Conventional transthoracic echocardiographic variables were compared between patients with arthritis and non-RA controls (n = 41). For rheumatoid arthritis patients, articular activity and rheumatologic and inflammatory markers were obtained. Results. Ventricular dysfunction was found in 54.3% of the population: systolic (18.1%), diastolic (32.4%), and/or right (24.8%), with lower ejection fraction (P < 0.0001). Pulmonary hypertension was found in 46.9%. Other echocardiographic findings included increased left atrial diameter (P = 0.01), aortic diameter (P = 0.01), ventricular septum (P = 0.01), left ventricular posterior wall (P = 0.013), and right ventricular (P = 0.01) and atrial diameters compared to control subjects. Rheumatoid factor and anti-CCP antibodies levels were significantly elevated in cases with ventricular dysfunction. Angina and myocardial infarction, diabetes, and dyslipidemia were the main risk factors for ventricular dysfunction. Conclusions. Ventricular dysfunction is common in rheumatoid arthritis and associated with longer disease duration and increased serologic markers of rheumatoid arthritis. Screening for cardiac abnormalities should be considered in this kind of patients.
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spelling pubmed-38668642013-12-24 Risk Factors for Asymptomatic Ventricular Dysfunction in Rheumatoid Arthritis Patients Garza-García, Carlos Rocío, Sánchez-Santillán Orea-Tejeda, Arturo Castillo-Martínez, Lilia Eduardo, Canseco López-Campos, José Luis Keirns-Davis, Candace ISRN Cardiol Research Article Objective. The aim of the study was to describe echocardiographic abnormalities in patients with rheumatoid arthritis, concurrent systemic comorbidities, rheumatologic clinical activity, serologic markers of rheumatoid arthritis, and inflammatory activity. Methods. In an observational, cross-sectional study, rheumatoid arthritis outpatients were included (n = 105). Conventional transthoracic echocardiographic variables were compared between patients with arthritis and non-RA controls (n = 41). For rheumatoid arthritis patients, articular activity and rheumatologic and inflammatory markers were obtained. Results. Ventricular dysfunction was found in 54.3% of the population: systolic (18.1%), diastolic (32.4%), and/or right (24.8%), with lower ejection fraction (P < 0.0001). Pulmonary hypertension was found in 46.9%. Other echocardiographic findings included increased left atrial diameter (P = 0.01), aortic diameter (P = 0.01), ventricular septum (P = 0.01), left ventricular posterior wall (P = 0.013), and right ventricular (P = 0.01) and atrial diameters compared to control subjects. Rheumatoid factor and anti-CCP antibodies levels were significantly elevated in cases with ventricular dysfunction. Angina and myocardial infarction, diabetes, and dyslipidemia were the main risk factors for ventricular dysfunction. Conclusions. Ventricular dysfunction is common in rheumatoid arthritis and associated with longer disease duration and increased serologic markers of rheumatoid arthritis. Screening for cardiac abnormalities should be considered in this kind of patients. Hindawi Publishing Corporation 2013-12-03 /pmc/articles/PMC3866864/ /pubmed/24368945 http://dx.doi.org/10.1155/2013/635439 Text en Copyright © 2013 Carlos Garza-García et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Garza-García, Carlos
Rocío, Sánchez-Santillán
Orea-Tejeda, Arturo
Castillo-Martínez, Lilia
Eduardo, Canseco
López-Campos, José Luis
Keirns-Davis, Candace
Risk Factors for Asymptomatic Ventricular Dysfunction in Rheumatoid Arthritis Patients
title Risk Factors for Asymptomatic Ventricular Dysfunction in Rheumatoid Arthritis Patients
title_full Risk Factors for Asymptomatic Ventricular Dysfunction in Rheumatoid Arthritis Patients
title_fullStr Risk Factors for Asymptomatic Ventricular Dysfunction in Rheumatoid Arthritis Patients
title_full_unstemmed Risk Factors for Asymptomatic Ventricular Dysfunction in Rheumatoid Arthritis Patients
title_short Risk Factors for Asymptomatic Ventricular Dysfunction in Rheumatoid Arthritis Patients
title_sort risk factors for asymptomatic ventricular dysfunction in rheumatoid arthritis patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3866864/
https://www.ncbi.nlm.nih.gov/pubmed/24368945
http://dx.doi.org/10.1155/2013/635439
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