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(123)I-ADAM SPET imaging of serotonin transporter in patients with epilepsy and comorbid depression

BACKGROUND: Purpose of the study was to investigate alterations in midbrain serotonin transporter (SERT) binding in patients with epilepsy and symptoms of depression compared to patients with epilepsy with no symptoms of depression. METHODS: We studied 12 patients with epilepsy (7 patients had focal...

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Autores principales: Liik, Maarika, Paris, Malle, Vahter, Liina, Gross-Paju, Katrin, Haldre, Sulev
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3866947/
https://www.ncbi.nlm.nih.gov/pubmed/24341899
http://dx.doi.org/10.1186/1471-2377-13-204
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author Liik, Maarika
Paris, Malle
Vahter, Liina
Gross-Paju, Katrin
Haldre, Sulev
author_facet Liik, Maarika
Paris, Malle
Vahter, Liina
Gross-Paju, Katrin
Haldre, Sulev
author_sort Liik, Maarika
collection PubMed
description BACKGROUND: Purpose of the study was to investigate alterations in midbrain serotonin transporter (SERT) binding in patients with epilepsy and symptoms of depression compared to patients with epilepsy with no symptoms of depression. METHODS: We studied 12 patients with epilepsy (7 patients had focal and 5 had generalized epilepsy syndromes). The presence of self-reported symptoms of depression was assessed using Beck Depression Inventory (BDI) and the Emotional State Questionnaire (EST-Q). The binding potential of the SERT was assessed by performing brain single photon emission tomography (SPET) using the SERT radioligand 2-((2-((dimethylamino)methyl)phenyl)thio)-5-(123)iodophenylamine ((123)I-ADAM). RESULTS: Seven patients had BDI and EST-Q subscale scores greater than 11 points, which was interpreted as the presence of symptoms of depression. We found that (123)I-ADAM binding was not significantly different between patients with epilepsy with and without symptoms of depression. In addition, (123)I-ADAM binding did not show a significant correlation to either BDI or EST-Q depression subscale scores and did not differ between patients with focal vs. generalized epilepsy. CONCLUSION: The results of our study failed to demonstrate alterations of SERT binding properties in patients with epilepsy with or without symptoms of depression.
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spelling pubmed-38669472013-12-19 (123)I-ADAM SPET imaging of serotonin transporter in patients with epilepsy and comorbid depression Liik, Maarika Paris, Malle Vahter, Liina Gross-Paju, Katrin Haldre, Sulev BMC Neurol Research Article BACKGROUND: Purpose of the study was to investigate alterations in midbrain serotonin transporter (SERT) binding in patients with epilepsy and symptoms of depression compared to patients with epilepsy with no symptoms of depression. METHODS: We studied 12 patients with epilepsy (7 patients had focal and 5 had generalized epilepsy syndromes). The presence of self-reported symptoms of depression was assessed using Beck Depression Inventory (BDI) and the Emotional State Questionnaire (EST-Q). The binding potential of the SERT was assessed by performing brain single photon emission tomography (SPET) using the SERT radioligand 2-((2-((dimethylamino)methyl)phenyl)thio)-5-(123)iodophenylamine ((123)I-ADAM). RESULTS: Seven patients had BDI and EST-Q subscale scores greater than 11 points, which was interpreted as the presence of symptoms of depression. We found that (123)I-ADAM binding was not significantly different between patients with epilepsy with and without symptoms of depression. In addition, (123)I-ADAM binding did not show a significant correlation to either BDI or EST-Q depression subscale scores and did not differ between patients with focal vs. generalized epilepsy. CONCLUSION: The results of our study failed to demonstrate alterations of SERT binding properties in patients with epilepsy with or without symptoms of depression. BioMed Central 2013-12-17 /pmc/articles/PMC3866947/ /pubmed/24341899 http://dx.doi.org/10.1186/1471-2377-13-204 Text en Copyright © 2013 Liik et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Liik, Maarika
Paris, Malle
Vahter, Liina
Gross-Paju, Katrin
Haldre, Sulev
(123)I-ADAM SPET imaging of serotonin transporter in patients with epilepsy and comorbid depression
title (123)I-ADAM SPET imaging of serotonin transporter in patients with epilepsy and comorbid depression
title_full (123)I-ADAM SPET imaging of serotonin transporter in patients with epilepsy and comorbid depression
title_fullStr (123)I-ADAM SPET imaging of serotonin transporter in patients with epilepsy and comorbid depression
title_full_unstemmed (123)I-ADAM SPET imaging of serotonin transporter in patients with epilepsy and comorbid depression
title_short (123)I-ADAM SPET imaging of serotonin transporter in patients with epilepsy and comorbid depression
title_sort (123)i-adam spet imaging of serotonin transporter in patients with epilepsy and comorbid depression
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3866947/
https://www.ncbi.nlm.nih.gov/pubmed/24341899
http://dx.doi.org/10.1186/1471-2377-13-204
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