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Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren’s syndrome
Sjögren’s syndrome is a common autoimmune disease (~0.7% of European Americans) typically presenting as keratoconjunctivitis sicca and xerostomia. In addition to strong association within the HLA region at 6p21 (P(meta)=7.65×10(−114)), we establish associations with IRF5-TNPO3 (P(meta)=2.73×10(−19))...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3867192/ https://www.ncbi.nlm.nih.gov/pubmed/24097067 http://dx.doi.org/10.1038/ng.2792 |
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| author | Lessard, Christopher J. Li, He Adrianto, Indra Ice, John A. Rasmussen, Astrid Grundahl, Kiely M. Kelly, Jennifer A. Dozmorov, Mikhail G. Miceli-Richard, Corinne Bowman, Simon Lester, Sue Eriksson, Per Eloranta, Maija-Leena Brun, Johan G. Gøransson, Lasse G. Harboe, Erna Guthridge, Joel M. Kaufman, Kenneth M. Kvarnström, Marika Jazebi, Helmi Graham, Deborah S. Cunninghame Grandits, Martha E. Nazmul-Hossain, Abu N. M. Patel, Ketan Adler, Adam J. Maier-Moore, Jacen S. Farris, A. Darise Brennan, Michael T. Lessard, James A. Chodosh, James Gopalakrishnan, Rajaram Hefner, Kimberly S. Houston, Glen D. Huang, Andrew J.W. Hughes, Pamela J. Lewis, David M. Radfar, Lida Rohrer, Michael D. Stone, Donald U. Wren, Jonathan D. Vyse, Timothy J. Gaffney, Patrick M. James, Judith A. Omdal, Roald Wahren-Herlenius, Marie Illei, Gabor G. Witte, Torsten Jonsson, Roland Rischmueller, Maureen Rönnblom, Lars Nordmark, Gunnel Ng, Wan-Fai Mariette, Xavier Anaya, Juan-Manuel Rhodus, Nelson L. Segal, Barbara M. Scofield, R. Hal Montgomery, Courtney G. Harley, John B. Sivils, Kathy L. Moser |
| author_facet | Lessard, Christopher J. Li, He Adrianto, Indra Ice, John A. Rasmussen, Astrid Grundahl, Kiely M. Kelly, Jennifer A. Dozmorov, Mikhail G. Miceli-Richard, Corinne Bowman, Simon Lester, Sue Eriksson, Per Eloranta, Maija-Leena Brun, Johan G. Gøransson, Lasse G. Harboe, Erna Guthridge, Joel M. Kaufman, Kenneth M. Kvarnström, Marika Jazebi, Helmi Graham, Deborah S. Cunninghame Grandits, Martha E. Nazmul-Hossain, Abu N. M. Patel, Ketan Adler, Adam J. Maier-Moore, Jacen S. Farris, A. Darise Brennan, Michael T. Lessard, James A. Chodosh, James Gopalakrishnan, Rajaram Hefner, Kimberly S. Houston, Glen D. Huang, Andrew J.W. Hughes, Pamela J. Lewis, David M. Radfar, Lida Rohrer, Michael D. Stone, Donald U. Wren, Jonathan D. Vyse, Timothy J. Gaffney, Patrick M. James, Judith A. Omdal, Roald Wahren-Herlenius, Marie Illei, Gabor G. Witte, Torsten Jonsson, Roland Rischmueller, Maureen Rönnblom, Lars Nordmark, Gunnel Ng, Wan-Fai Mariette, Xavier Anaya, Juan-Manuel Rhodus, Nelson L. Segal, Barbara M. Scofield, R. Hal Montgomery, Courtney G. Harley, John B. Sivils, Kathy L. Moser |
| author_sort | Lessard, Christopher J. |
| collection | PubMed |
| description | Sjögren’s syndrome is a common autoimmune disease (~0.7% of European Americans) typically presenting as keratoconjunctivitis sicca and xerostomia. In addition to strong association within the HLA region at 6p21 (P(meta)=7.65×10(−114)), we establish associations with IRF5-TNPO3 (P(meta)=2.73×10(−19)), STAT4 (P(meta)=6.80×10(−15)), IL12A (P(meta) =1.17×10(−10)), FAM167A-BLK (P(meta)=4.97×10(−10)), DDX6-CXCR5 (P(meta)=1.10×10(−8)), and TNIP1 (P(meta)=3.30×10(−8)). Suggestive associations with P(meta)<5×10(−5) were observed with 29 regions including TNFAIP3, PTTG1, PRDM1, DGKQ, FCGR2A, IRAK1BP1, ITSN2, and PHIP amongst others. These results highlight the importance of genes involved in both innate and adaptive immunity in Sjögren’s syndrome. |
| format | Online Article Text |
| id | pubmed-3867192 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2013 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-38671922014-05-01 Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren’s syndrome Lessard, Christopher J. Li, He Adrianto, Indra Ice, John A. Rasmussen, Astrid Grundahl, Kiely M. Kelly, Jennifer A. Dozmorov, Mikhail G. Miceli-Richard, Corinne Bowman, Simon Lester, Sue Eriksson, Per Eloranta, Maija-Leena Brun, Johan G. Gøransson, Lasse G. Harboe, Erna Guthridge, Joel M. Kaufman, Kenneth M. Kvarnström, Marika Jazebi, Helmi Graham, Deborah S. Cunninghame Grandits, Martha E. Nazmul-Hossain, Abu N. M. Patel, Ketan Adler, Adam J. Maier-Moore, Jacen S. Farris, A. Darise Brennan, Michael T. Lessard, James A. Chodosh, James Gopalakrishnan, Rajaram Hefner, Kimberly S. Houston, Glen D. Huang, Andrew J.W. Hughes, Pamela J. Lewis, David M. Radfar, Lida Rohrer, Michael D. Stone, Donald U. Wren, Jonathan D. Vyse, Timothy J. Gaffney, Patrick M. James, Judith A. Omdal, Roald Wahren-Herlenius, Marie Illei, Gabor G. Witte, Torsten Jonsson, Roland Rischmueller, Maureen Rönnblom, Lars Nordmark, Gunnel Ng, Wan-Fai Mariette, Xavier Anaya, Juan-Manuel Rhodus, Nelson L. Segal, Barbara M. Scofield, R. Hal Montgomery, Courtney G. Harley, John B. Sivils, Kathy L. Moser Nat Genet Article Sjögren’s syndrome is a common autoimmune disease (~0.7% of European Americans) typically presenting as keratoconjunctivitis sicca and xerostomia. In addition to strong association within the HLA region at 6p21 (P(meta)=7.65×10(−114)), we establish associations with IRF5-TNPO3 (P(meta)=2.73×10(−19)), STAT4 (P(meta)=6.80×10(−15)), IL12A (P(meta) =1.17×10(−10)), FAM167A-BLK (P(meta)=4.97×10(−10)), DDX6-CXCR5 (P(meta)=1.10×10(−8)), and TNIP1 (P(meta)=3.30×10(−8)). Suggestive associations with P(meta)<5×10(−5) were observed with 29 regions including TNFAIP3, PTTG1, PRDM1, DGKQ, FCGR2A, IRAK1BP1, ITSN2, and PHIP amongst others. These results highlight the importance of genes involved in both innate and adaptive immunity in Sjögren’s syndrome. 2013-10-06 2013-11 /pmc/articles/PMC3867192/ /pubmed/24097067 http://dx.doi.org/10.1038/ng.2792 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms |
| spellingShingle | Article Lessard, Christopher J. Li, He Adrianto, Indra Ice, John A. Rasmussen, Astrid Grundahl, Kiely M. Kelly, Jennifer A. Dozmorov, Mikhail G. Miceli-Richard, Corinne Bowman, Simon Lester, Sue Eriksson, Per Eloranta, Maija-Leena Brun, Johan G. Gøransson, Lasse G. Harboe, Erna Guthridge, Joel M. Kaufman, Kenneth M. Kvarnström, Marika Jazebi, Helmi Graham, Deborah S. Cunninghame Grandits, Martha E. Nazmul-Hossain, Abu N. M. Patel, Ketan Adler, Adam J. Maier-Moore, Jacen S. Farris, A. Darise Brennan, Michael T. Lessard, James A. Chodosh, James Gopalakrishnan, Rajaram Hefner, Kimberly S. Houston, Glen D. Huang, Andrew J.W. Hughes, Pamela J. Lewis, David M. Radfar, Lida Rohrer, Michael D. Stone, Donald U. Wren, Jonathan D. Vyse, Timothy J. Gaffney, Patrick M. James, Judith A. Omdal, Roald Wahren-Herlenius, Marie Illei, Gabor G. Witte, Torsten Jonsson, Roland Rischmueller, Maureen Rönnblom, Lars Nordmark, Gunnel Ng, Wan-Fai Mariette, Xavier Anaya, Juan-Manuel Rhodus, Nelson L. Segal, Barbara M. Scofield, R. Hal Montgomery, Courtney G. Harley, John B. Sivils, Kathy L. Moser Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren’s syndrome |
| title | Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren’s syndrome |
| title_full | Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren’s syndrome |
| title_fullStr | Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren’s syndrome |
| title_full_unstemmed | Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren’s syndrome |
| title_short | Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren’s syndrome |
| title_sort | variants at multiple loci implicated in both innate and adaptive immune responses are associated with sjögren’s syndrome |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3867192/ https://www.ncbi.nlm.nih.gov/pubmed/24097067 http://dx.doi.org/10.1038/ng.2792 |
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