Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren’s syndrome

Sjögren’s syndrome is a common autoimmune disease (~0.7% of European Americans) typically presenting as keratoconjunctivitis sicca and xerostomia. In addition to strong association within the HLA region at 6p21 (P(meta)=7.65×10(−114)), we establish associations with IRF5-TNPO3 (P(meta)=2.73×10(−19))...

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Autores principales: Lessard, Christopher J., Li, He, Adrianto, Indra, Ice, John A., Rasmussen, Astrid, Grundahl, Kiely M., Kelly, Jennifer A., Dozmorov, Mikhail G., Miceli-Richard, Corinne, Bowman, Simon, Lester, Sue, Eriksson, Per, Eloranta, Maija-Leena, Brun, Johan G., Gøransson, Lasse G., Harboe, Erna, Guthridge, Joel M., Kaufman, Kenneth M., Kvarnström, Marika, Jazebi, Helmi, Graham, Deborah S. Cunninghame, Grandits, Martha E., Nazmul-Hossain, Abu N. M., Patel, Ketan, Adler, Adam J., Maier-Moore, Jacen S., Farris, A. Darise, Brennan, Michael T., Lessard, James A., Chodosh, James, Gopalakrishnan, Rajaram, Hefner, Kimberly S., Houston, Glen D., Huang, Andrew J.W., Hughes, Pamela J., Lewis, David M., Radfar, Lida, Rohrer, Michael D., Stone, Donald U., Wren, Jonathan D., Vyse, Timothy J., Gaffney, Patrick M., James, Judith A., Omdal, Roald, Wahren-Herlenius, Marie, Illei, Gabor G., Witte, Torsten, Jonsson, Roland, Rischmueller, Maureen, Rönnblom, Lars, Nordmark, Gunnel, Ng, Wan-Fai, Mariette, Xavier, Anaya, Juan-Manuel, Rhodus, Nelson L., Segal, Barbara M., Scofield, R. Hal, Montgomery, Courtney G., Harley, John B., Sivils, Kathy L. Moser
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3867192/
https://www.ncbi.nlm.nih.gov/pubmed/24097067
http://dx.doi.org/10.1038/ng.2792

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